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T0070907

T0070907 Structure
CAS No.
313516-66-4
Chemical Name:
T0070907
Synonyms
CS-2314;T 0070907;T0070907 USP/EP/BP;T0070907 (T-0070907;2-CHLORO-5-NITRO-N-(4-PYRIDYL)BENZAMIDE;2-CHLORO-5-NITRO-N-4-PYRIDINYLBENZAMIDE;T0070907 - CAS 313516-66-4 - Calbiochem;N1-(4-PYRIDYL)-2-CHLORO-5-NITROBENZAMIDE;BenzaMide, 2-chloro-5-nitro-N-4-pyridinyl-
CBNumber:
CB4771443
Molecular Formula:
C12H8ClN3O3
Molecular Weight:
277.66
MOL File:
313516-66-4.mol
MSDS File:
SDS
Modify Date:
2023/6/30 15:45:59
Request For Quotation

T0070907 Properties

Melting point >184°C (dec.)
Density 1.498
storage temp. 2-8°C
solubility DMSO: >10mg/mL
form White solid
color white
Water Solubility Soluble in DMSO at 10mg/ml. Insoluble in water.
Sensitive Light Sensitive

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H335-H302-H319
Precautionary statements  P305+P351+P338-P261-P280a-P304+P340-P405-P501a
Hazard Codes  Xn
Risk Statements  22-36
Safety Statements  26
WGK Germany  2
HS Code  29333990
NFPA 704
1
2 0

T0070907 price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) T8703 T0070907 ≥98% (HPLC) 313516-66-4 5MG ₹19116.95 2022-06-14 Buy
Sigma-Aldrich(India) T8703 T0070907 ≥98% (HPLC) 313516-66-4 25MG ₹70925.4 2022-06-14 Buy
Product number Packaging Price Buy
T8703 5MG ₹19116.95 Buy
T8703 25MG ₹70925.4 Buy

T0070907 Chemical Properties,Uses,Production

Description

The peroxisome proliferator-activated receptor-γ (PPARγ) is the nuclear receptor responsible for transducing the therapeutic activity of the thiazolidinediones (TZDs). TZDs are a group of structurally related synthetic PPARγ receptor agonists with antidiabetic actions in vivo. There are many PPARγ agonists, including 15-deoxy-Δ12,14-prostaglandin J2 and azelaoyl PAF, which are naturally derived. However, only a few antagonists have been reported. T0070907 is a potent and selective antagonist of the human PPARγ with an apparent IC50 of 1 nM for the binding inhibition of rosiglitazone, a reference TZD. T0070907 covalently binds to Cys313 of PPARγ, inducing conformational changes that block the recruitment of transcriptional cofactors to the PPARγ/RXR heterodimer.

Chemical Properties

Off-White Solid

Uses

T0070907 has been used to reduce peroxisome proliferator-activated receptor gamma (PPAR-γ) expression in lipopolysaccharide (LPS)-induced leukemia RAW264.7 cell line. It also has been used to evaluate the involvement of wogonin in alleviating EtOH (ethanol)-induced inflammation in RAW264.7 cell line.

General Description

T0070907 has antimicrotubule, antitumor and radiosensitizing properties. It decreases tubulin protein levels, which is associated with cell cycle arrest, apoptosis and also reduces metastasis of colorectal carcinoma cells. T0070907 is used as a therapeutic target in breast cancer. It stimulates proteasome-dependent degradation of tubulin.

Biological Activity

Potent and selective PPAR γ antagonist (IC 50 = 1 nM). Displays > 800-fold selectivity for PPAR γ over PPAR α and PPAR δ . In vitro, blocks transcriptional activity of PPAR γ and inhibits rosiglitazone-induced adipogenesis.

T0070907 Preparation Products And Raw materials

Raw materials

Preparation Products

T0070907 Suppliers

Global( 137)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
CONIER CHEM AND PHARMA LIMITED +8618523575427 China 49391 58 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29826 58 Inquiry
Dideu Industries Group Limited +86-29-89586680 +86-15129568250 China 25247 58 Inquiry
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 +1-2135480471 China 10522 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 United States 19973 58 Inquiry
SUZHOU SENFEIDA CHEMICAL CO.,LTD +86-0512-83500002 +8615195660023 China 23053 58 Inquiry
LEAPCHEM CO., LTD. +86-852-30606658 China 43348 58 Inquiry
Supplier Advantage
A.J Chemicals 58
ATK CHEMICAL COMPANY LIMITED 60
CONIER CHEM AND PHARMA LIMITED 58
career henan chemical co 58
Dideu Industries Group Limited 58
Zhejiang J&C Biological Technology Co.,Limited 58
InvivoChem 58
TargetMol Chemicals Inc. 58
SUZHOU SENFEIDA CHEMICAL CO.,LTD 58
LEAPCHEM CO., LTD. 58

T0070907 Spectrum

T0070907(313516-66-4)1HNMR

313516-66-4(T0070907)Related Search:

Linoleic acid CIGLITAZONE GW9662 Linolenic acid Troglitazone
WY-14643 Y27632 (hydrochloride) MK-2206 2HCl SB 431542 4-Chloro-N-[2-[[5-(trifluoromethyl)-2-pyridinyl]sulfonyl]ethyl]benzamide
Rosiglitazone maleate Linolenic acid T0070907 2-CHLORO-5-NITROBENZAMIDE 4-ACETAMIDOPYRIDINE
5-amino-2-chloro-N-methylbenzamide 4-Benzylaminopyridine N1-(4-PYRIDYL)BENZAMIDE
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2-CHLORO-5-NITRO-N-4-PYRIDINYLBENZAMIDE 2-CHLORO-5-NITRO-N-(4-PYRIDYL)BENZAMIDE T 0070907 N1-(4-PYRIDYL)-2-CHLORO-5-NITROBENZAMIDE BenzaMide, 2-chloro-5-nitro-N-4-pyridinyl- T0070907 - CAS 313516-66-4 - Calbiochem CS-2314 T0070907 (T-0070907 T0070907 USP/EP/BP 313516-66-4 C12H8N3O3Cl Intracellular receptor PPARγ antagonist Inhibitor Inhibitors