Linoleic acid
- CAS No.
- 60-33-3
- Chemical Name:
- Linoleic acid
- Synonyms
- Linoleic;9,12-OCTADECADIENOIC ACID;LINOLEATE;(9Z,12Z)-Octadeca-9,12-dienoic acid;LINOLIC ACID;(Z,Z)-9,12-Octadecadienoic acid;CASTOR OIL FATTY ACID;9,12-Linoleic acid;Linoleic Acid (peroxide free);9,12-octadecadienoic
- CBNumber:
- CB5764024
- Molecular Formula:
- C18H32O2
- Molecular Weight:
- 280.45
- MOL File:
- 60-33-3.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/10/29 14:18:57
| Melting point | -5 °C (lit.) |
|---|---|
| Boiling point | 229-230 °C/16 mmHg (lit.) |
| Density | 0.902 g/mL at 25 °C (lit.) |
| FEMA | 3380 | 9,12-OCTADECADIENOIC ACID (48%) AND 9,12,15-OCTADECATRIENOIC ACID (52%) |
| refractive index |
n |
| Flash point | >230 °F |
| storage temp. | Store below +30°C. |
| solubility | NaOH: soluble1M |
| pka | 4.77(at 25℃) |
| form | liquid |
| color | Clear yellow |
| Odor | faint fatty |
| Water Solubility | INSOLUBLE |
| FreezingPoint | -5℃ |
| Sensitive | Air Sensitive |
| λmax | 270nm(H2O)(lit.) |
| JECFA Number | 332 |
| Merck | 14,5505 |
| BRN | 1727101 |
| Dielectric constant | 2.6（0℃） |
| Stability | Stable, but air and light sensitive. Combustible. Incompatible with strong oxidizing agents. |
| InChIKey | OYHQOLUKZRVURQ-KQHSAVHASA-N |
| LogP | 7.050 |
| CAS DataBase Reference | 60-33-3(CAS DataBase Reference) |
| NIST Chemistry Reference | 9,12-Octadecadienoic acid (Z,Z)-(60-33-3) |
| EPA Substance Registry System | Linoleic acid (60-33-3) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225-H319 | |||||||||
| Precautionary statements | P210-P305+P351+P338-P370+P378-P403+P235 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36-36/37/38 | |||||||||
| Safety Statements | 26-24/25-36-37/39 | |||||||||
| RIDADR | UN1170 - class 3 - PG 2 - Ethanol | |||||||||
| WGK Germany | 1 | |||||||||
| RTECS | RF9990000 | |||||||||
| F | 8-10-23 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29161500 | |||||||||
| Toxicity | LD50 oral in mouse: > 50gm/kg | |||||||||
| NFPA 704 |
|
Linoleic acid price More Price(33)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | W800075 | Linoleic acid natural (US), ≥95%, FG | 60-33-3 | 1SAMPLE | ₹5196 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | W800075 | Linoleic acid natural (US), ≥95%, FG | 60-33-3 | 100G | ₹13217.33 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | W800075 | Linoleic acid natural (US), ≥95%, FG | 60-33-3 | 1KG | ₹59342.65 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | W338020 | Linoleic acid ≥95%, FG | 60-33-3 | 1SAMPLE | ₹5141.88 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | L1376 | Linoleic acid ≥99% | 60-33-3 | 10MG | ₹2760.38 | 2022-06-14 | Buy |
Linoleic acid Chemical Properties,Uses,Production
Description
Linoleic acid is an essential ω-6 polyunsaturated fatty acid (PUFA). It is the most abundant PUFA in a variety of foods, and dietary sources of linoleic acid include vegetable oils, meats, nuts, seeds, and eggs. Linoleic acid (30 μM) increases migration of IEC-6 rat intestinal epithelial cells in a wound healing assay. Rats fed a linoleate-deficient diet exhibit decreased body weight and an increased ratio of eicosatrienoate to arachidonate in liver and serum phospholipids compared with rats fed a control diet, as well as mild scaling of forepaw skin.
Chemical Properties
Linoleic acid occurs as a colorless to light-yellow-colored oil.
Uses
linoleic acid (vitamin F) is also known as omega-6. An emulsifier, it is also cleansing, emollient, and skin conditioning. Some formulations incorporate it as a surfactant. Linoleic acid prevents dryness and roughness. A deficiency of linoleic acid in the skin is associated with symptoms similar to those characterizing eczema, psoriasis, and a generally poor skin condition. In numerous laboratory studies where a linoleic acid deficiency was induced, a topical application of linoleic acid in its free or esterified form quickly reversed this condition. In addition, there is some evidence in laboratory tests that linoleic acid may inhibit melanin production by decreasing tyrosinase activity and suppressing melanin polymer formation within melanosomes. Linoleic acid is an essential fatty acid found in a variety of plant oils, including soybean and sunflower.
Definition
linoleic acid: A liquid polyunsaturatedfatty acid with two doublebonds, CH3(CH2)4CH:CHCH2-CH:CH(CH2)7COOH.Linoleic acid isabundant in plant fats and oils,e.g.linseed oil, groundnut oil,and soyabeanoil.It is an essential fatty acid.
Production Methods
Linoleic acid is obtained by extraction from various vegetable oils such as safflower oil.
General Description
Colorless to straw colored liquid. A polyunsaturated fatty acid essential to human diet.
Air & Water Reactions
Sensitive to air and light. . Oxidizes across carbon double bonds
Reactivity Profile
Linoleic acid reacts to neutralize bases. May react vigorously with oxidizing agents. May react exothermically with reducing agents to release hydrogen gas.
Fire Hazard
Flash point data for Linoleic acid are not available. Linoleic acid is probably combustible.
Pharmaceutical Applications
Linoleic acid is used in topical transdermal formulations, in oral formulations as an absorption enhancer, and in topical cosmetic formulations as an emulsifying agent, and in aqueous microemulsions.It is also used in parenteral emulsions for total parenteral nutrition and in nonprescription oral dietary supplements.
Safety
Linoleic acid is widely used in cosmetics and topical pharmaceutical formulations, and is generally regarded as a nontoxic material. On exposure to the eyes, skin, and mucous membranes, linoleic acid can cause mild irritation.
storage
Linoleic acid is sensitive to air, light, moisture, and heat. It should be stored in a tightly sealed container under an inert atmosphere and refrigerated.
Incompatibilities
Linoleic acid is incompatible with bases, strong oxidizing agents, and reducing agents.
Regulatory Status
GRAS listed. Approved for use in foods in Europe and the USA.
Linoleic acid Preparation Products And Raw materials
Raw materials
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chevron_right| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Neugen Labs | +91-8133254502 +91-8133254502 | Karnataka, India | 195 | 58 | Inquiry |
| Progress Life Sciences Pvt Ltd | +91-2265101706 +91-2249781414 | Maharashtra, India | 38 | 58 | Inquiry |
| Acme Synthetic Chemicals | +91-2226762959 +91-9833260962 | Maharashtra, India | 31 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6100 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6257 | 58 | Inquiry |
| CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6700 | 30 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6768 | 58 | Inquiry |
| Otto Chemie Pvt. Ltd. | +91 9820041841 | Mumbai, India | 5870 | 58 | Inquiry |
| Ankit Polymers Industries | 08048603127 | Ahmedabad, India | 69 | 58 | Inquiry |
| Bansal Trading Company | 07942536103 | Delhi, India | 8 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Neugen Labs | 58 |
| Progress Life Sciences Pvt Ltd | 58 |
| Acme Synthetic Chemicals | 58 |
| A.J Chemicals | 58 |
| CLEARSYNTH LABS LTD. | 58 |
| CHEMSWORTH | 30 |
| TCI Chemicals (India) Pvt. Ltd. | 58 |
| Otto Chemie Pvt. Ltd. | 58 |
| Ankit Polymers Industries | 58 |
| Bansal Trading Company | 58 |
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