CIGLITAZONE
- CAS No.
- 74772-77-3
- Chemical Name:
- CIGLITAZONE
- Synonyms
- AD-4533;U-63287;ADD 3878;CIGLITIZONE;CIGLITAZONE;CIGLITLZONE;Ciglitazona;CIGLITAZONE USP/EP/BP;Ciglitazone Solution, 100ppm;CIGLITAZONE(SUBJECTTOPATENTFREE)
- CBNumber:
- CB5416208
- Molecular Formula:
- C18H23NO3S
- Molecular Weight:
- 333.45
- MOL File:
- 74772-77-3.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/6/30 15:45:59
| Melting point | 130-131°C |
|---|---|
| Boiling point | 504.5±23.0 °C(Predicted) |
| Density | 1.189±0.06 g/cm3(Predicted) |
| storage temp. | Store at RT |
| solubility | Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml). |
| form | Tan solid |
| pka | 6.36±0.50(Predicted) |
| color | Tan |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Warning |
| Hazard statements | H361 |
| Precautionary statements | P201-P202-P281-P308+P313-P405-P501 |
| WGK Germany | 3 |
| RTECS | XJ5813700 |
| HS Code | 29341000 |
CIGLITAZONE price More Price(2)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | C3974 | Ciglitizone ≥98% (HPLC) | 74772-77-3 | 5MG | ₹37227.18 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 230950 | Ciglitazone - CAS 74772-77-3 - Calbiochem A potent thiazolinedione (TDZ) type anti-hyperglycemic agent and a selective PPARγ agonist (EC?? = 3 μM). | 74772-77-3 | 5MG | ₹21209.99 | 2022-06-14 | Buy |
CIGLITAZONE Chemical Properties,Uses,Production
Chemical Properties
White Cyrstalline Solid
Originator
Ciglitazone, synthetized by Takeda and reported in 1982, was a result of screening of clofibrate analogues for hypolipidemic activity.
Definition
ChEBI: An aromatic ether that consists of 1,3-thiazolidine-2,4-dione with position 5 substituted by a 4-[(1-methylcyclohexyl)methoxy]benzyl group. A selective PPARgamma agonist.
General Description
A potent thiazolinedione (TDZ) type anti-hyperglycemic agent and a selective PPARγ agonist (EC50 = 3 μM).
Biological Activity
Selective agonist at PPAR γ (peroxisome proliferator-activated receptor γ ). Activates PPAR γ with an EC 50 value of 3 μ M in vitro , and is at least 33-fold selective over PPAR α and δ . Antihyperglycemic in vivo .
Pharmacology
Ciglitazone reduced plasma triglycerides, hyperglycemia and hyperinsulinemia in several insulin resistant diabetic and nondiabetic rodent models after repeated oral dosing at doses of 100 – 300 mg/kg body weight, while having little or no effect in normal rodents or those with insulin deficient diabetes. In long-term animal studies lens cataracts occurred and ciglitazone development was discontinued.
Mode of action
Ciglitizone is a thiazolidine-2,4-dione derivative. The mechanism of blood glucose lowering activity by thiazolidinedione derivatives has not been fully elucidated yet. Only minor or no effects are observed in normal animals or insulin sensitive diabetes models. In obese or hyperinsulinemic insulin resistant rodents thiazolidinediones lower insulin and triglyceride levels after treatment for 2 to 8 d. If hyperglycemia occurs, also the blood glucose concentration is reduced. Mechanistic in vitro studies with adipocytes have shown that the thiazolidinediones are ligands of the peroxisome proliferator activated receptor. Peroxisome proliferator activated receptors (PPARs) belong to the nuclear receptor superfamily of ligand-activated transcription factors. So far, three receptor subtypes have been identified: PPAR , PPAR , and PPAR . The PPARs are believed to play a physiological role in the regulation of lipid metabolism. The in vivo antihyperglycemic activity of thiazolidinediones strongly correlates with their potency as PPAR agonists in vitro.
CIGLITAZONE Preparation Products And Raw materials
Raw materials
Preparation Products
CIGLITAZONE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | China | 9030 | 58 | Inquiry |
| Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503259 +86-19930503259 | China | 18435 | 58 | Inquiry |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | China | 33350 | 58 | Inquiry |
| Yantai Boyun Biological Technology Co. Ltd | 13793517650; 13793517650 | China | 2878 | 58 | Inquiry |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | China | 4552 | 58 | Inquiry |
| Nanjing Tengyi Biotechnology Co., Ltd | 025-58851786 17714337195 | China | 5591 | 58 | Inquiry |
| ShangHai Anpel Co, Ltd. | 18501792038; 18501792038 | China | 9614 | 58 | Inquiry |
| Nantong Hanfang Biotechnology Co. , Ltd. | 18616537568 | China | 30968 | 58 | Inquiry |
| RD International Technology Co., Limited | 18024082417 | China | 9282 | 58 | Inquiry |
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