Apafant

CAS No.: 105219-56-5

Chemical Name:: Apafant

Synonyms: WEB 208;Apafant;WEB 2086;WEB 2086BS;4-[3-[4[(2-Chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a]diazepin-2-yl]-1-oxopropyl]morpholine;4-[3-[4[(2-CHLOROPHENYL)-9-METHYL-6H-THIENO[3,2-F][1,2,4]TRIAZOLO[4,3-A]DIAZEPIN-2-YL]-1-OXOPROPYL]]MORPHOLINE;4-(2-Chlorophenyl)-9-methyl-2-(3-morpholino-3-oxopropyl)-6H-thieno[3,2- f] [1,2,4]triazolo[4,3-a][1,4]diazepine;4-[3-[4-(2-Chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-α][1,4]diazepin-2-yl]-1-oxopropyl]-morpholine;4-[3-[4-(2-Chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-2-yl]-1-oxopropyl]-morpholine;3-[4-(2-Chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-2-yl]-1-(4-morpholinyl)-1-propanone

CBNumber:: CB5252385

Molecular Formula:: C22H22ClN5O2S

Molecular Weight:: 455.96

MOL File:: 105219-56-5.mol

MSDS File:: SDS

Modify Date:: 2023/6/30 15:45:59

Request For Quotation

Apafant Properties

Melting point	186-188°C
Boiling point	720.2±70.0 °C(Predicted)
Density	1.48
storage temp.	2-8°C
solubility	DMSO: soluble10mg/mL (clear solution)
pka	2.36±0.40(Predicted)
form	powder
color	white to beige
Stability	Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS08
Signal word	Warning
Hazard statements	H361
Precautionary statements	P201-P202-P281-P308+P313-P405-P501
WGK Germany	3
Toxicity	LD50 in mice (mg/kg): 540 i.v.; 4600 orally (Casals-Stenzel)

Apafant price More Price(2)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	SML0238	WEB2086 ≥98% (HPLC)	105219-56-5	5MG	₹15869.45	2022-06-14	Buy
Sigma-Aldrich(India)	SML0238	WEB2086 ≥98% (HPLC)	105219-56-5	25MG	₹63964.93	2022-06-14	Buy

Product number	Packaging	Price	Buy
SML0238	5MG	₹15869.45	Buy
SML0238	25MG	₹63964.93	Buy

Apafant Chemical Properties,Uses,Production

Chemical Properties

White Solid

Uses

Platelet activating factor (PAF) antagonist.

Biological Activity

Potent, selective platelet-activating factor (PAF) receptor antagonist (K i = 16.3 nM). Displays anti-inflammatory, antiangiogenic and anticancer activity. Inhibits growth and proliferation of MCF-7 breast cancer cells.

Apafant Preparation Products And Raw materials

Raw materials

Preparation Products

1,1-dicyclohexylurea

Apafant Suppliers

Global( 75)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
CONIER CHEM AND PHARMA LIMITED	+8618523575427	China	49391	58	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	United States	19892	58	Inquiry
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	China	30253	58	Inquiry
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	China	49739	58	Inquiry
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	China	3136	58	Inquiry
SUZHOU SENFEIDA CHEMICAL CO.,LTD	+86-0512-83500002 +8615195660023	China	23053	58	Inquiry
Aladdin Scientific	+1-+1(833)-552-7181	United States	52927	58	Inquiry
DC Chemicals	021-58447131 13564518121	China	9412	58	Inquiry
TargetMol Chemicals Inc.	4008200310	China	24016	58	Inquiry

Supplier	Advantage
CLEARSYNTH LABS LTD.	58
CONIER CHEM AND PHARMA LIMITED	58
TargetMol Chemicals Inc.	58
Career Henan Chemica Co	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	58
Nantong HI-FUTURE Biology Co., Ltd.	58
SUZHOU SENFEIDA CHEMICAL CO.,LTD	58
Aladdin Scientific	58
DC Chemicals	58
TargetMol Chemicals Inc.	58

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4-[3-[4-(2-Chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-2-yl]-1-oxopropyl]-morpholine WEB 208 WEB 2086BS 4-[3-[4-(2-Chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-α][1,4]diazepin-2-yl]-1-oxopropyl]-morpholine 3-[4-(2-Chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-2-yl]-1-(4-morpholinyl)-1-propanone 4-(2-Chlorophenyl)-9-methyl-2-(3-morpholino-3-oxopropyl)-6H-thieno[3,2- f] [1,2,4]triazolo[4,3-a][1,4]diazepine 4-[3-[4[(2-CHLOROPHENYL)-9-METHYL-6H-THIENO[3,2-F][1,2,4]TRIAZOLO[4,3-A]DIAZEPIN-2-YL]-1-OXOPROPYL]]MORPHOLINE WEB 2086 Apafant 4-[3-[4[(2-Chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a]diazepin-2-yl]-1-oxopropyl]morpholine 1-Propanone, 3-[4-(2-chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-2-yl]-1-(4-morpholinyl)- 105219-56-5 C22H22ClN5O2S C22H22N5O2SCl PAF receptor Intermediates & Fine Chemicals Pharmaceuticals Sulfur & Selenium Compounds