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Apafant

Apafant Structure
  • ₹15869.45 - ₹63964.93
  • Product name: Apafant
  • CAS: 105219-56-5
  • MF: C22H22ClN5O2S
  • MW: 455.96
  • EINECS:
  • MDL Number:MFCD00865271
  • Synonyms:4-[3-[4-(2-Chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-2-yl]-1-oxopropyl]-morpholine;WEB 208;WEB 2086BS;4-[3-[4-(2-Chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-α][1,4]diazepin-2-yl]-1-oxopropyl]-morpholine;3-[4-(2-Chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-2-yl]-1-(4-morpholinyl)-1-propanone;4-(2-Chlorophenyl)-9-methyl-2-(3-morpholino-3-oxopropyl)-6H-thieno[3,2- f] [1,2,4]triazolo[4,3-a][1,4]diazepine;4-[3-[4[(2-CHLOROPHENYL)-9-METHYL-6H-THIENO[3,2-F][1,2,4]TRIAZOLO[4,3-A]DIAZEPIN-2-YL]-1-OXOPROPYL]]MORPHOLINE;WEB 2086
Price2 Properties Safety Information Description
2 prices
Selected condition：

Brand

  • Sigma-Aldrich(India)

Package

  • 5MG
  • 25MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML0238
  • Product descriptionWEB2086 ≥98% (HPLC)
  • Packaging5MG
  • Price₹15869.45
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML0238
  • Product descriptionWEB2086 ≥98% (HPLC)
  • Packaging25MG
  • Price₹63964.93
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) SML0238 WEB2086 ≥98% (HPLC) 5MG ₹15869.45 2022-06-14 Buy
Sigma-Aldrich(India) SML0238 WEB2086 ≥98% (HPLC) 25MG ₹63964.93 2022-06-14 Buy

Properties

Melting point :186-188°C
Boiling point :720.2±70.0 °C(Predicted)
Density :1.48
storage temp. :2-8°C
solubility :DMSO: soluble10mg/mL (clear solution)
pka :2.36±0.40(Predicted)
form :powder
color :white to beige
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H361 Suspected of damaging fertility or the unborn child Reproductive toxicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P281 Use personal protective equipment as required.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

Platelet-activating factor (PAF) is a biologically active phospholipid that activates platelets, polymorphonuclear leukocytes, monocytes, and macrophages. PAF also increases vascular permeability, decreases cardiac output, induces hypotension, stimulates uterine contraction, and has been implicated in pathological processes, such as inflammation and allergy. Apafant is a water soluble, selective PAF receptor antagonist that inhibits PAF binding to human PAF receptors with a Ki value of 9.9 nM. Apafant displays anti-inflammatory, antiangiogenic, and anticancer activity.

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