Rosiglitazone
- CAS No.
- 122320-73-4
- Chemical Name:
- Rosiglitazone
- Synonyms
- AVANDIA;ROSIGLITAZONE HCL;Rosig;RosigL;itazone;BRL 49653;50MG/1G/1KG;ROSIGLIAZONE;roiglitazone;ROSIGLITAZONE
- CBNumber:
- CB7133275
- Molecular Formula:
- C18H19N3O3S
- Molecular Weight:
- 357.43
- MOL File:
- 122320-73-4.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/6/11 18:14:38
| Melting point | 153-155 C |
|---|---|
| Boiling point | 585.0±35.0 °C(Predicted) |
| Density | 1.315±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: ≥10mg/mL |
| pka | 6.34±0.50(Predicted) |
| form | powder |
| color | White to Off-White |
| Merck | 14,8265 |
| CAS DataBase Reference | 122320-73-4(CAS DataBase Reference) |
| IARC | 3 (Vol. 108) 2016 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS08,GHS07,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H319-H410-H361 | |||||||||
| Precautionary statements | P273-P391-P501-P264-P280-P305+P351+P338-P337+P313P-P201-P202-P281-P308+P313-P405-P501 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/38 | |||||||||
| Safety Statements | 26-37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | XJ5813850 | |||||||||
| HS Code | 2934100000 | |||||||||
| NFPA 704 |
|
Rosiglitazone price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | R2408 | Rosiglitazone ≥98% (HPLC) | 122320-73-4 | 10MG | ₹10110.55 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | R2408 | Rosiglitazone ≥98% (HPLC) | 122320-73-4 | 50MG | ₹40983.45 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR2932 | Rosiglitazone Pharmaceutical Secondary Standard; Certified Reference Material | 122320-73-4 | 300MG | ₹20545.85 | 2022-06-14 | Buy |
| TCI Chemicals (India) | R0106 | Rosiglitazone | 122320-73-4 | 200MG | ₹4500 | 2022-05-26 | Buy |
| TCI Chemicals (India) | R0106 | Rosiglitazone | 122320-73-4 | 1G | ₹10800 | 2022-05-26 | Buy |
Rosiglitazone Chemical Properties,Uses,Production
Uses
Rosiglitazone is an insulin sensitizer; binds to peroxisome proliferator activated receptor gamma (PPAR- γ).
Indications
Rosiglitazone is approved for use as monotherapy and in conjunction with metformin, though it is sometimes combined with a sulfonylurea or insulin. It is usually taken once or twice a day with or without food. Rosiglitazone may cause a modest increase in lowdensity lipoprotein and triglyceride concentrations, but it is unclear whether this effect has any clinical significance or persists in the long term.
General Description
Rosiglitazone is 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione, and is availableas the maleate salt in tablets containing the drug alone(Avandia) or in combination products with metformin(Avandamet) or with glimepiride (Avandaryl). The2-aminopyridine moiety allows for salt formation; the marketedformulations contain the 1:1 salt with maleic acid, inwhich the pyridine nitrogen accepts a proton, forming the2-aminopyridinium species.
Clinical Use
Although rosiglitazone is extensively biotransformed—playing the major role in both transformations, and some involvementof CYP2C9.21,47 The sulfate conjugate M10 is thepredominant circulating metabolite by 4-hour postdose. Theextraordinarily high plasma protein binding of this metabolite(and the N-demethylated sulfate conjugate M4) in humans accountsfor the lengthy residence time of the radioactivity in thebody, despite the relatively short pharmacokinetic half-life(4–4.5 hours) of rosiglitazone itself.
Rosiglitazone Preparation Products And Raw materials
Raw materials
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chevron_rightPreparation Products
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| A.R. Life Sciences Pvt Ltd | +9140-23097679 | New Delhi, India | 16 | 49 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
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| Primarius Custom Synthesis P. Ltd. | +91 (265) 233-1730 | New Delhi, India | 43 | 0 | Inquiry |
| Pharma Chemicals | 08069033787Ext 987 | Hyderabad, India | 130 | 58 | Inquiry |
| Amegh Pharma Pvt., Ltd. | 91-22-66711627 | Maharashtra, India | 37 | 58 | Inquiry |