2,4-Thiazolidinedione
- CAS No.
- 2295-31-0
- Chemical Name:
- 2,4-Thiazolidinedione
- Synonyms
- THIAZOLIDINE-2,4-DIONE;TZD;Thiazolidinedione;2,4-Thiazolidindione;U 25560;idinedione;usafek-5496;2,4-ThiazoL;USAF ek-5496;AURORA 23272
- CBNumber:
- CB6675365
- Molecular Formula:
- C3H3NO2S
- Molecular Weight:
- 117.13
- MOL File:
- 2295-31-0.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/10/25 16:21:11
Melting point | 125-127 °C (lit.) |
---|---|
Boiling point | 178-179 °C (19 mmHg) |
Density | 1.408 (estimate) |
vapor pressure | 0Pa at 25℃ |
refractive index | 1.5130 (estimate) |
Flash point | 178-179°C/19mm |
storage temp. | Sealed in dry,Room Temperature |
solubility | DMSO (Slightly), Methanol (Slightly) |
pka | 6.50±0.10(Predicted) |
form | Crystalline Powder |
color | Slightly yellow |
Water Solubility | Soluble in water (30 mg/ml at 3°C), methanol, DMSO, ethanol, and ethyl ether. |
BRN | 110700 |
InChIKey | ZOBPZXTWZATXDG-UHFFFAOYSA-N |
LogP | -0.29 at 25℃ |
CAS DataBase Reference | 2295-31-0(CAS DataBase Reference) |
NIST Chemistry Reference | 2,4-Thiazolidinedione(2295-31-0) |
EPA Substance Registry System | 2,4-Thiazolidinedione (2295-31-0) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS06 |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|
Signal word | Warning | |||||||||
Hazard statements | H301 | |||||||||
Precautionary statements | P264-P270-P301+P310a-P321-P405-P501a | |||||||||
Hazard Codes | Xi | |||||||||
Risk Statements | 36/37/38 | |||||||||
Safety Statements | 24/25-36-26 | |||||||||
WGK Germany | 3 | |||||||||
RTECS | XJ5775000 | |||||||||
TSCA | Yes | |||||||||
HazardClass | IRRITANT | |||||||||
HS Code | 29341000 | |||||||||
NFPA 704 |
|
2,4-Thiazolidinedione price More Price(5)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich(India) | 375004 | 2,4-Thiazolidinedione technical grade, 90% | 2295-31-0 | 25G | ₹3570 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | 375004 | 2,4-Thiazolidinedione technical grade, 90% | 2295-31-0 | 100G | ₹6900 | 2022-06-14 | Buy |
TCI Chemicals (India) | T1990 | 2,4-Thiazolidinedione min. 98.0 % | 2295-31-0 | 25G | ₹3700 | 2022-05-26 | Buy |
TCI Chemicals (India) | T1990 | 2,4-Thiazolidinedione min. 98.0 % | 2295-31-0 | 100G | ₹5100 | 2022-05-26 | Buy |
TCI Chemicals (India) | T1990 | 2,4-Thiazolidinedione min. 98.0 % | 2295-31-0 | 500G | ₹9100 | 2022-05-26 | Buy |
2,4-Thiazolidinedione Chemical Properties,Uses,Production
Chemical Properties
White to Off-White Powder
Uses
2,4-Thiazolidinedione may be used in the synthesis of sixteen 5-arylidene-2,4-thiazolidinediones, via ultrasound-promoted aldol condensation reaction. It may be used as starting material for the synthesis of drugs with antihyperglycemic activity.
Definition
ChEBI: A thiazolidenedione carrying oxo substituents at positions 2 and 4.
General Description
2,4-Thiazolidinedione is a well-known peroxisome proliferator-activated receptors (PPAR) activator. Its effect on aging process using kidneys from Fischer 344 rats has been reported. A library of conjugates of 2,4-thiazolidinedione has been synthesized by Knoevenagel condensation followed by reduction using hydrogen gas and Pd/C catalyst. Knoevenagel condensation of various aromatic aldehydes with 2,4-thiazolidinedione in polyethylene glycol-300 has been reported.
2,4-Thiazolidinedione Preparation Products And Raw materials
Raw materials
Preparation Products
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