Pioglitazone
- CAS No.
- 111025-46-8
- Chemical Name:
- Pioglitazone
- Synonyms
- U 72107;PINEPOLLEN;Pioglitazone;Pioglitozaone;Pioglitazone (Actos);Pioglitazone free base;Pioglitazone USP/EP/BP;Pioglitazone (AD-4833);Phenyl Acetate Impurity 45;Pioglitazone and its intermeidates
- CBNumber:
- CB9257580
- Molecular Formula:
- C19H20N2O3S
- Molecular Weight:
- 356.44
- MOL File:
- 111025-46-8.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/6/30 15:45:59
| Melting point | 183-184 C |
|---|---|
| Boiling point | 575.4±45.0 °C(Predicted) |
| Density | 1.260±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | DMSO (Slightly, Heated) |
| form | White to off-white solid. |
| pka | 6.35±0.50(Predicted) |
| color | White to Off-White |
| IARC | 2A (Vol. 108) 2016 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H312-H332-H351-H361 | |||||||||
| Precautionary statements | P280 | |||||||||
| Hazard Codes | F,C | |||||||||
| Risk Statements | 11-34 | |||||||||
| Safety Statements | 16-26-36/37/39-45 | |||||||||
| NFPA 704 |
|
Pioglitazone Chemical Properties,Uses,Production
Description
Pioglitazone is an agonist of the peroxisome proliferator-activated receptor γ (PPARγ; EC50 = ~500-600 nM for both human and murine PPARγ). It is selective for PPARγ over PPARα, exhibiting low level activation of PPARα at 1 μM and 5.4-fold activation at a concentration of 10 μM. Pioglitazone inhibits pyruvate oxidation and glucose production in hepatocytes when used at a concentration of 10 μM. In vivo, pioglitazone (0.3-3 mg/kg per day) reduces hyperglycemia, hyperlipidemia, and hyperinsulinemia in a dose-dependent manner in male Wistar fatty rats. It reduces the number of lesions in a transgenic rat adenocarcinoma of prostate (TRAP) model. Pioglitazone (2.5 mg/kg) also decreases production of neuroinflammatory cytokines and reduces immobility in the forced swim and tail suspension tests in a mouse model of chronic mild stress, indicating antidepressant-like activity that can be reversed by the PPARγ antagonist GW9662 .
Uses
Pioglitazone shows antidiabetic activity in patients with type 2 diabetes mellitus.
Indications
Pioglitazone is approved for use as monotherapy and in conjunction with metformin, sulfonylureas, and insulin. It is taken once a day with or without food. Though pioglitazone may also cause a small increase in low-density lipoprotein concentrations, there is usually a modest decrease in triglyceride levels, but it unclear whether this has any clinical significance or persists in the long term.
Definition
ChEBI: A member of the class of thiazolidenediones that is 1,3-thiazolidine-2,4-dione substituted by a benzyl group at position 5 which in turn is substituted by a 2-(5-ethylpyridin-2-yl)ethoxy group at position 4 of the phenyl ring. It exhibits hypoglycemic acti ity.
General Description
Pioglitazone, (±)-5-[[4-[2-(5-ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-2,4-thiazolidinedione (Actos),is an odorless, white, crystalline powder that must be convertedto a salt such as its hydrochloride before it will haveany water solubility. Although the molecule contains one chiralcenter, the compound is used as the racemic mixture. Thisis primarily a result of the in vivo interconversion of the twoenantiomers. Thus, there are no differences in the pharmacologicalactivity of the two enantiomers.
Pioglitazone Preparation Products And Raw materials
Raw materials
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chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Varanous Labs Pvt Ltd | +91-7036248882 +91-7036248882 | Hyderabad, India | 1541 | 58 | Inquiry |
| Vidgas science and technologies Pvt Ltd | +91-9030019844 +91-9030019844 | Telangana, India | 76 | 58 | Inquiry |
| Smilax Laboratories Limited | +91-8919514965 +91-8008333438 | Telangana, India | 28 | 58 | Inquiry |
| Lakshmi Farmachem | +91-9948795885 +91-9550886476 | Telangana, India | 407 | 58 | Inquiry |
| Stellar Chemical Laboratories Pvt., Ltd. | +91-66662691 +91-2266662690 | Maharashtra, India | 11 | 58 | Inquiry |
| Abhilasha Pharma Pvt Ltd | +91-9824153455 +91-9227135395 | Gujarat, India | 18 | 58 | Inquiry |
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| Manus Aktteva | +91 (79) 6512-3395 | New Delhi, India | 581 | 34 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Varanous Labs Pvt Ltd | 58 |
| Vidgas science and technologies Pvt Ltd | 58 |
| Smilax Laboratories Limited | 58 |
| Lakshmi Farmachem | 58 |
| Stellar Chemical Laboratories Pvt., Ltd. | 58 |
| Abhilasha Pharma Pvt Ltd | 58 |
| Ralington Pharma | 58 |
| Manus Aktteva | 34 |
| CLEARSYNTH LABS LTD. | 58 |
| A.J Chemicals | 58 |
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