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Hydroxypioglitazone

Hydroxypioglitazone Structure
CAS No.
146062-44-4
Chemical Name:
Hydroxypioglitazone
Synonyms
Leriglitazone;HYDROXYPIOGLITAZONE;Hydroxypioglitazone M4;Pioglitazone Impurity 4;Pioglitazone Impurity 18;Pioglitazone M4 Metabolite;Pioglitazone, hydroxy M-IV;Hydroxy Pioglitazone (M-IV) ;Hydroxy Pioglitazone Solution, 100ppm;5-[[4-[2-[5-(1-HYDROXYETHYL)-2-PYRIDINYL]ETHOXY] PHENYL]METHYL]-2,4-THIAZOLIDINEDIONE
CBNumber:
CB1299313
Molecular Formula:
C19H20N2O4S
Molecular Weight:
372.44
MOL File:
146062-44-4.mol
MSDS File:
SDS
Modify Date:
2023/7/12 16:47:46
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Hydroxypioglitazone Properties

Melting point 157-1580C
Boiling point 627.6±55.0 °C(Predicted)
Density 1.325±0.06 g/cm3(Predicted)
storage temp. -20°C Freezer, Under Inert Atmosphere
solubility DMSO (Slightly), Methanol (Slightly, Sonicated)
pka 6.35±0.50(Predicted)
form Solid
color White to Off-White
Stability Hygroscopic
CAS DataBase Reference 146062-44-4

Hydroxypioglitazone Chemical Properties,Uses,Production

Description

Hydroxy pioglitazone is a major metabolite of the peroxisome proliferator-activated receptor γ (PPARγ) agonist pioglitazone (Item Nos. 71745 | 22263 | 10028). It is formed from pioglitazone by the cytochrome P450 (CYP) isoform CYP2C8 with minor contributions from CYP3A4. Hydroxy pioglitazone binds to PPARγ (Ki = 1.2 μM) and activates PPARγ in a time-resolved FRET (TR-FRET) assay (EC50 = 2.1 μM).

Chemical Properties

Off-White Solid

Uses

A metabolite of Pioglitazone (P471000).

Hydroxypioglitazone Preparation Products And Raw materials

Raw materials

Benzaldehyde, 4-[2-[5-[1-(methoxymethoxy)ethyl]-2-pyridinyl]ethoxy]- ethyl 3-(2-methyl-5-pyridyl)-3-oxopropionate 5-(1-(MethoxyMethoxy)ethyl)-2-Methylpyridine 2-(5-(1-(MethoxyMethoxy)ethyl)pyridin-2-yl)ethanol 5-(4-(2-(5-(1-(MethoxyMethoxy)ethyl)pyridin-2-yl)ethoxy)benzyl)thiazolidine-2,4-dione
5-ACETYL-2-METHYLPYRIDINE Methyl 6-methylnicotinate
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Preparation Products

Hydroxypioglitazone Suppliers

Global( 73)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Varanous Labs Pvt Ltd +91-7036248882 +91-7036248882 Hyderabad, India 1541 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6773 58 Inquiry
SynZeal Research Pvt Ltd +1 226-802-2078 Gujarat, India 6522 58 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29901 58 Inquiry
Chongqing Chemdad Co., Ltd +86-023-6139-8061 +86-86-13650506873 China 39916 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
Finetech Industry Limited +86-27-87465837 +8618971612321 China 9626 58 Inquiry
sgtlifesciences pvt ltd +8617013299288 China 12382 58 Inquiry
China National Standard Pharmaceutical Corporation Limited +8615391658522 China 11927 58 Inquiry
Supplier Advantage
Varanous Labs Pvt Ltd 58
CLEARSYNTH LABS LTD. 58
Pharmaffiliates Analytics and Synthetics P. Ltd 58
SynZeal Research Pvt Ltd 58
career henan chemical co 58
Chongqing Chemdad Co., Ltd 58
TargetMol Chemicals Inc. 58
Finetech Industry Limited 58
sgtlifesciences pvt ltd 58
China National Standard Pharmaceutical Corporation Limited 58

146062-44-4(Hydroxypioglitazone)Related Search:

Pioglitazone 4'-Hydroxyacetophenone Pioglitazone Troglitazone Gliquidone
Pioglitazone hydrochloride a-[(Aminocarbonyl)thio]-4-[2-(5-ethyl-2-pyridinyl)ethoxy]benzenepropanoic Acid Ethyl Ester Pioglitazone Aldehyde Impurity 5-(4-Fluorobenzyl)-2,4-thiazolidinedione 4-[2-(5-Ethyl-2-pyridinyl)ethoxy]benzyaldehyde
Hydroxy Pioglitazone (M-II) (Mixture of Diastereomers) Pioglitazone Sulfonic Acid IMpurity 2-[2-(4-BroMophenoxy)ethyl]-5-ethylpyridine Pioglitazone Impurity 5-{4-[2-(5-Ethyl-2-pyridyl)ethoxy]benzyl}-2-imino-4-thiazolidinone
Pioglitazone N-Oxide 5-(4-Hydroxybenzyl)-2,4-thiazolidinedione 5-[[4-[2-(5-ACETYL-2-PYRIDINYL)ETHOXY]PHENYL]METHYL]-2,4THIAZOLIDINEDIONE
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HYDROXYPIOGLITAZONE Hydroxy Pioglitazone (M-IV) 5-[[4-[2-[5-(1-HYDROXYETHYL)-2-PYRIDINYL]ETHOXY] PHENYL]METHYL]-2,4-THIAZOLIDINEDIONE Pioglitazone, hydroxy M-IV Pioglitazone Impurity 18 Hydroxy Pioglitazone Solution, 100ppm Pioglitazone M4 Metabolite Leriglitazone Pioglitazone Impurity 4 2,4-Thiazolidinedione, 5-[[4-[2-[5-(1-hydroxyethyl)-2-pyridinyl]ethoxy]phenyl]methyl]- Hydroxypioglitazone M4 146062-44-4 Sulfur & Selenium Compounds Various Metabolites and Impurities Intermediates & Fine Chemicals Metabolites & Impurities Pharmaceuticals