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2-Methyl-4-isothiazolin-3-one

2-Methyl-4-isothiazolin-3-one Structure
CAS No.
2682-20-4
Chemical Name:
2-Methyl-4-isothiazolin-3-one
Synonyms
2-METHYL-4-ISOTHIAZOLIN-3-ONE;2-METHYL-3(2H)-ISOTHIAZOLONE;2-Methylisothiazol-3(2H)-one;2-Methyl-4-isothiazolin-3-on;METHYLISOTHIAZOLONE;Casson preservatives;2-methyl-2H-isothiazol-3-one;2-METHYL-4-ISOTHIAZOLINE-3-ONE;2-Methyl-3-isothiazolone;2-Methyl-2H-isothiazole-3-one
CBNumber:
CB0193926
Molecular Formula:
C4H5NOS
Molecular Weight:
115.15
MOL File:
2682-20-4.mol
MSDS File:
SDS
Modify Date:
2024/7/2 8:54:57
Request For Quotation

2-Methyl-4-isothiazolin-3-one Properties

Melting point 254-256 °C(lit.)
Boiling point bp0.03 93°
Density 1.25 (14% aq.)
vapor pressure <0.1 mm Hg ( 25 °C)
storage temp. 2-8°C
solubility Chloroform, Ethyl Acetate
pka -2.03±0.20(Predicted)
form Solid
color Yellow
Water Solubility 489g/L at 20℃
BRN 606203
InChIKey BEGLCMHJXHIJLR-UHFFFAOYSA-N
LogP -0.486 at 20℃
CAS DataBase Reference 2682-20-4(CAS DataBase Reference)
NIST Chemistry Reference 3(2H)-isothiazolone, 2-methyl-(2682-20-4)
EPA Substance Registry System 2-Methyl-3(2H)-isothiazolone (2682-20-4)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS05,GHS06,GHS09
Signal word  Danger
Hazard statements  H301+H311-H314-H317-H330-H410
Precautionary statements  P260-P273-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338
Hazard Codes  N,C,T
Risk Statements  50/53-50-43-34-20/21/22-37-23-22
Safety Statements  60-61-36/37/39-26-24-45
RIDADR  UN 3077 9/PG 3
WGK Germany  2
RTECS  FE1250000
HazardClass  8
PackingGroup  III
HS Code  29349990

2-Methyl-4-isothiazolin-3-one price More Price(3)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) 725765 2-Methyl-4-isothiazolin-3-one 95% 2682-20-4 5G ₹6256.85 2022-06-14 Buy
Sigma-Aldrich(India) 73569 2-Methyl-4-isothiazolin-3-one analytical standard 2682-20-4 1G ₹9742.5 2022-06-14 Buy
Sigma-Aldrich(India) 725765 2-Methyl-4-isothiazolin-3-one 95% 2682-20-4 25G ₹19030.35 2022-06-14 Buy
Product number Packaging Price Buy
725765 5G ₹6256.85 Buy
73569 1G ₹9742.5 Buy
725765 25G ₹19030.35 Buy

2-Methyl-4-isothiazolin-3-one Chemical Properties,Uses,Production

Description

2-Methyl-4-isothiazolin-3-one (MI) is an isothiazolinone-derived biocide used for controlling microbial growth in industrial and household products, often in a mixture with 5-chloro-2-methyl-3-isothiazolone (MCI). MI is active against Gram-positive and Gram-negative bacteria, fungi, and yeast with MIC values of 0.0045, 0.0015, >0.01, and 0.0065% (w/w) for S. aureus, P. aeruginosa, A. niger, and C. albicans, respectively, when used alone. MIC values are 7 to 200-fold lower when MI is used in combination with MCI. MI decreases neurite outgrowth of rat cortical neurons when used at concentrations of 0.1-3 μM and inhibits Src family kinases in cell-free assays. MI, alone and as a mixture with MCI, can elicit contact sensitization.

Chemical Properties

2-Methyl-4-isothiazolin-3-one (MIT) is a colorless,clear liquid with amild odor that is completely soluble in water; mostly soluble in acetonitrile, methanol, and hexane; and slightly soluble in xylene. MIT is a heterocyclic organic compound used as a preservative in cosmetics and personal care products in concentrations up to 0.01%.

Uses

Methylisothiazolinone is a preservative compound widely used in cosmetics. It is a contact allergen and sensitiser. Methylisothiazolinone has recently been identified as a neurotoxin that can damage nerve endings with repeated exposure.

Uses

2-Methyl-4-isothiazolin-3-one (methylisothiazolinone) is a isothiazolinone based biocide and preservative used in personal care products. 2-Methyl-4-isothiazolin-3-one is also used for controlling microbial growth in water-c ontaining solution.

Definition

ChEBI: Methylisothiazolinone is a 1,2-thazole that is 4-isothiazolin-3-one bearing a methyl group on the nitrogen atom. It is a powerful biocide and preservative and is the minor active ingredient in the commercial product Kathon(TM). It has a role as an antifouling biocide, an antimicrobial agent and an antifungal agent.

Preparation

2-Methyl-4-isothiazolin-3-one (MIT)is prepared by cyclization of cis-N-methyl-3-thiocyanoacrylamide:    NCSCH=CHC(O)NHCH3?SCH=CHC(O)NCH3+HCN

Hazard

2-Methyl-4-isothiazolin-3-one(MIT)is allergenic and cytotoxic, and this has led to some concern over its use.A report released by the European Scientific Committee on Cosmetic Products and Non-food Products Intended for Consumers (SCCNFP) in 2003 also concluded that insufficient information was available to allow for an adequate risk assessment analysis of MIT.

Contact allergens

MI is generally associated with MCI, in Kathon? CG, MCI/MI, and Euxyl? K 100. This preservative is currently used in water-based products such as cosmetics, paints, and glues. Skin contact with concentrated solution can cause severe irritant dermatitis.

Side effects

Early on, dermatitis may occur only on part of the exposed skin. Common patterns include: hand dermatitis，perianal dermatitis, perivulval dermatitis, napkin dermatitis, facial dermatitis, eyelid swelling, and scalp dermatitis. Later, more extensive and severe whole-body contact dermatitis may occur in very sensitive people.

2-Methyl-4-isothiazolin-3-one Preparation Products And Raw materials

Raw materials

Preparation Products

2-Methyl-4-isothiazolin-3-one Suppliers

Global( 476)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Murli Krishna Exports Pvt Ltd +91-2225631595 +91-2225631594 New Delhi, India 185 58 Inquiry
Earthchem Laboratories P Ltd +91-9923536956 +91-9923536947 Maharashtra, India 59 58 Inquiry
Speciality Organics Pvt Ltd 9959551278 AndhraPradesh, India 19 58 Inquiry
Salicylates and Chemicals Pvt. Ltd. +91-8879630551 +91-8898005838 Maharashtra, India 61 58 Inquiry
Pearl Chemicals 08046057281 Mumbai, India 35 58 Inquiry
Triveni chemicals 08048762458 New Delhi, India 6093 58 Inquiry
Sai Siddhi 07942551420 Gujarat, India 95 58 Inquiry
Royal Chem 08068441024Ext 576 Delhi, India 5 58 Inquiry
Akshar Exim Company Private Limited 07942541146 Mumbai, India 89 58 Inquiry
Real Herbal & Chemicals 08046061717 Delhi, India 21 58 Inquiry
Supplier Advantage
Murli Krishna Exports Pvt Ltd 58
Earthchem Laboratories P Ltd 58
Speciality Organics Pvt Ltd 58
Salicylates and Chemicals Pvt. Ltd. 58
Pearl Chemicals 58
Triveni chemicals 58
Sai Siddhi 58
Royal Chem 58
Akshar Exim Company Private Limited 58
Real Herbal & Chemicals 58

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