1,2-Benzisothiazol-3(2H)-one
- CAS No.
- 2634-33-5
- Chemical Name:
- 1,2-Benzisothiazol-3(2H)-one
- Synonyms
- BIT;1,2-BENZISOTHIAZOLIN-3-ONE;BENZISOTHIAZOLINONE;BIT-85;Benzo[d]isothiazol-3(2H)-one;BENZISOTHIAZOLONE;proxel;1,2-Benzisothiazolin;Benzisothiazolin-3-on (BIT);1,2-benzisothiazoline-3-one
- CBNumber:
- CB1496512
- Molecular Formula:
- C7H5NOS
- Molecular Weight:
- 151.19
- MOL File:
- 2634-33-5.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/2 8:55:01
| Melting point | 154-158 °C(lit.) |
|---|---|
| Boiling point | 360°C (rough estimate) |
| Density | 1.2170 (rough estimate) |
| vapor pressure | 0Pa at 25℃ |
| refractive index | 1.5500 (estimate) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Soluble in dichloromethane, dimethyl sulfoxide, methanol. |
| pka | 10.19±0.20(Predicted) |
| form | Solid |
| color | White to Light yellow to Light orange |
| Water Solubility | 1.288g/L at 20℃ |
| InChIKey | DMSMPAJRVJJAGA-UHFFFAOYSA-N |
| LogP | 0.7 at 20℃ |
| CAS DataBase Reference | 2634-33-5 |
| EPA Substance Registry System | 1,2-Benzisothiazolin-3-one (2634-33-5) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS05,GHS07,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H315-H317-H318-H400 | |||||||||
| Precautionary statements | P261-P273-P280-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xn,N | |||||||||
| Risk Statements | 22-38-41-43-50 | |||||||||
| Safety Statements | 24-26-37/39-61 | |||||||||
| RIDADR | UN 3077 9/PG 3 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | DE4620000 | |||||||||
| HazardClass | 9 | |||||||||
| HazardClass | IRRITANT | |||||||||
| PackingGroup | Ⅲ | |||||||||
| HS Code | 29339900 | |||||||||
| Toxicity | LD50 oral in rat: 1020mg/kg | |||||||||
| NFPA 704 |
|
1,2-Benzisothiazol-3(2H)-one price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 561487 | 1,2-Benzisothiazol-3(2H)-one 97% | 2634-33-5 | 5G | ₹10608.5 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 75169 | 1,2-Benzisothiazol-3(2H)-one analytical standard | 2634-33-5 | 100MG | ₹13715.28 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 561487 | 1,2-Benzisothiazol-3(2H)-one 97% | 2634-33-5 | 25G | ₹23836.65 | 2022-06-14 | Buy |
| TCI Chemicals (India) | B2430 | 1,2-Benzisothiazol-3(2H)-one min. 98.0 % | 2634-33-5 | 25G | ₹5800 | 2022-05-26 | Buy |
| TCI Chemicals (India) | B2430 | 1,2-Benzisothiazol-3(2H)-one min. 98.0 % | 2634-33-5 | 100G | ₹6900 | 2022-05-26 | Buy |
1,2-Benzisothiazol-3(2H)-one Chemical Properties,Uses,Production
Description
BIT (1,2-Benzisothiazol-3(2H)-one) is an irritant and also a skin sensitizer. Occupational allergie contact dermatitis has been reported mainly related to the use of cutting oils and greases in paint manufacturers, pottery mouldmakers, acrylic emulsion manufacturers, plumbers, printers and lithoprinters, paper makers, an analyticallaboratory, a rubber factory, and in employees manufacturing air fresheners.
Chemical Properties
Yellow Powder
Uses
Antimicrobial agent.
Definition
ChEBI: Benzo[d]isothiazol-3-one is an organic heterobicyclic compound based on a fused 1,2-thiazole and benzene bicyclic ring skeleton, with the S atom positioned adjacent to one of the positions of ring fusion. It has a role as a disinfectant, a platelet aggregation inhibitor, an environmental contaminant, a xenobiotic, a drug allergen and a sensitiser. It is an organonitrogen heterocyclic compound and an organic heterobicyclic compound.
General Description
1,2-Benzisothiazol-3(2H)-one is a commonly used biocide in industrial and consumer products, which possesses antimicrobial activity against gram positive and gram negative bacteria. It is mainly used in packaging, adhesives, detergents, disinfectants, sunscreen lotions, paints and lubricants.
Contact allergens
1,2-Benzisothiazol-3(2H)-one, both an irritant and a skin sensitizer, is widely used in industry as a preservative in water-based solutions such as pastes, paints, and cutting oils. Occupational dermatitis has been reported mainly due to cutting fluids and greases, in paint manufacturers, pottery moldmakers, acrylic emulsions manufacturers, plumber,printers and lithoprinters, paper makers, analytical laboratory, rubber factory, and employees manufacturing air fresheners. It is also a preservative in vinyl gloves.
Safety Profile
Moderately toxic by ingestion.When heated to decomposition it emits toxic vapors ofNOx and SOx.
Toxicity evaluation
Isothiazolinones, such as 1,2-benzisothiazol-3(2H)-one (BIT), are widely used as biocides for bacterial growth control in many domestic and industrial processes. Despite their advantages as biocides, they are highly toxic and pose a potential risk to the environment. BIT could seriously inhibit the growth of Scenedesmus sp. LX1, Chlorella sp. HQ, and Chlamydomonas reinhardtii with half maximal effective concentrations at 72 h (72h-EC50) of 1.70, 0.41, and 1.16 mg/L, respectively. The primary inhibition mechanism was the BIT-induced damage to microalgal photosynthetic systems.
1,2-Benzisothiazol-3(2H)-one Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Bhausa Life Sciences | +91-8154986830 +91-8154986830 | Gujarat, India | 201 | 58 | Inquiry |
| ANJI BIOSCIENCES | +91-9000100077 +91-9000100077 | Hyderabad, India | 430 | 58 | Inquiry |
| VGS SYNTHESIS PRIVATE LIMITED | +91-9866975588 +91-9866975588 | Hyderabad, India | 1818 | 58 | Inquiry |
| Siddharth Chemicals | +91-9823371550 +91-9370368055 | New Delhi, India | 6 | 58 | Inquiry |
| Riddhesh Pharmachem | +91-9106014993 +91-9106014993 | Gujarat, India | 126 | 58 | Inquiry |
| Integrin Life Sciences. Pvt. Ltd. | +91-4040265469 +91-9849990870 | Hyderabad, India | 90 | 58 | Inquiry |
| Syrohchem Laboratories Pvt Ltd | +91-7559397527 +91-9370522022 | Maharashtra, India | 18 | 58 | Inquiry |
| Earthchem Laboratories P Ltd | +91-9923536956 +91-9923536947 | Maharashtra, India | 59 | 58 | Inquiry |
| Speciality Organics Pvt Ltd | 9959551278 | AndhraPradesh, India | 19 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
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