Melatonine
- CAS No.
- 73-31-4
- Chemical Name:
- Melatonine
- Synonyms
- MELATONIN;MLT;N-ACETYL-5-METHOXYTRYPTAMINE;melotonin;Melatonin (AS);Melatonine Powder;5-METHOXY-N-ACETYLTRYPTAMINE;N-(2-(5-methoxyindol-3-yl)ethyl)acetamide;N-[2-(5-METHOXY-1H-INDOL-3-YL)ETHYL]ACETAMIDE;MLK7
- CBNumber:
- CB5364927
- Molecular Formula:
- C13H16N2O2
- Molecular Weight:
- 232.28
- MOL File:
- 73-31-4.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/9/4 16:41:41
| Melting point | 116.5-118 °C (lit.) |
|---|---|
| Boiling point | 374.44°C (rough estimate) |
| Density | 1.1099 (rough estimate) |
| refractive index | 1.6450 (estimate) |
| Flash point | 9℃ |
| storage temp. | -20°C |
| solubility | Soluble in ethanol to at least 50mg/ml |
| form | Powder |
| pka | 16.26±0.46(Predicted) |
| color | white to off-white |
| Merck | 14,5816 |
| BRN | 205542 |
| InChIKey | DRLFMBDRBRZALE-UHFFFAOYSA-N |
| LogP | 1.043 (est) |
| CAS DataBase Reference | 73-31-4(CAS DataBase Reference) |
| NIST Chemistry Reference | Melatonin(73-31-4) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS02,GHS06,GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H225-H301+H311+H331-H370 |
| Precautionary statements | P210-P260-P280-P301+P310-P311 |
| Hazard Codes | T,F |
| Risk Statements | 60-39/23/24/25-23/24/25-11 |
| Safety Statements | 24/25-99-53-45-36/37-16-7 |
| RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution |
| WGK Germany | 2 |
| RTECS | AC5955000 |
| F | 8-10-23 |
| HS Code | 29379000 |
| Toxicity | LD50 orally in Rabbit: > 3200 mg/kg |
Melatonine price More Price(17)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | M5250 | Melatonin powder, ≥98% (TLC) | 73-31-4 | 250MG | ₹4741.35 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | M5250 | Melatonin powder, ≥98% (TLC) | 73-31-4 | 1G | ₹10521.9 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR1767 | Melatonin Pharmaceutical Secondary Standard; Certified Reference Material | 73-31-4 | 500MG | ₹14613.75 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | M5250 | Melatonin powder, ≥98% (TLC) | 73-31-4 | 5G | ₹41015.93 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | M5250 | Melatonin powder, ≥98% (TLC) | 73-31-4 | 10G | ₹74616.73 | 2022-06-14 | Buy |
Melatonine Chemical Properties,Uses,Production
Description
Melatonin, at times referred to as the “hormone of darkness,” normally is secreted during the night. It is synthesized in the pineal gland, and its secretion is controlled by the suprachiasmatic nucleus, following an endogenous circadian rhythm. Studies indicate that melatonin may
Chemical Properties
Off-White Powder
Occurrence
Melatonin is a naturally occurring hormone in the body.
Uses
Melatonine can be used in sleep induction, modifies circadian rhythm, antioxidant, free radical scavenger
Definition
ChEBI: A member of the class of acetamides that is acetamide in which one of the hydrogens attached to the nitrogen atom is replaced by a 2-(5-methoxy-1H-indol-3-yl)ethyl group. It is a hormone secreted by the pineal gland in humans.
World Health Organization (WHO)
Melatonin is promoted as a cure for travel sickness, jet-lag and insomnia and has recently been claimed in the United States to reverse the ageing process. A synthetic version has been freely available from health food shops and pharmacies as a "nutritional supplement" since 1993.
General Description
A hormone that has been postulated as being a mediator of photic-induced anti-gonadotropic activity in photoperiodic mammals. Counteracts the apoptotic effects of etoposide in bone marrow cells. Melatonin receptors are coupled to a G-protein system. Inhibits rat cerebellar nitric oxide synthase (NOS).
Biological Activity
Endogenous hormone that acts as an agonist at melatonin receptors MT 1 and MT 2 . Exhibits a prominent role in the control of circadian rhythm, displays immunomodulatory activity and acts as a powerful antioxidant in vivo .
Clinical Use
Melatonin is most effective in young individuals and appears to be less effective in elderly individuals (possibly because of a decreased number of receptors). Melatonin causes a phase shift of approximately 1 hour per day. This means that the use of melatonin in the morning can delay the onset of evening sleepiness, whereas melatonin taken in the evening has been associated with faster onset of sleep and increased total sleep time. Melatonin is sold as a food supplement in the United States, but it has become popular for use as a hypnotic and for alleviating jet lag (a flight across five or more time zones) and helping to resynchronize individuals who have difficulty adapting to night-shift work. have effects on circadian rhythm and sleep processes. The presence of a pharmacologically specific receptor for melatonin in which the molecular structure is known are referred to as MT1, MT2, and MT3 receptors. The MT1 and MT2 receptors are high-affinity G protein coupled receptors, whereas MT3 is a form of quinone reductase. The MT1 receptor appears to be primarily involved in initiating sleep, whereas the MT2 receptor appears to mediate melatonins effect in the eye, circadian rhythm, and vascular effects. The importance of MT3, although widely distributed in different tissues, is currently unknown. The normal physiological concentration of melatonin observed at night is approximately 100 to 200 pg/mL, and oral doses of 0.1 to 0.3 mg of melatonin are adequate to obtain these concentrations even though melatonin frequently is given at doses of 1 to 10 mg to obtain supraphysiological levels. These higher doses may be the reason for some of the side effects not currently associated with the melatonin receptors.
Melatonine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Mehta Pharmaceutical Industries | +91-8390068777 +91-8390068777 | Mumbai, India | 30 | 58 | Inquiry |
| KARPSCHEM LABORATORIES | +91-7249203006 +91-7249203006 | Maharashtra, India | 786 | 58 | Inquiry |
| PANCHSHEEL ORGANICS LTD | +91-9821053955 +91-9324201019 | Mumbai, India | 82 | 58 | Inquiry |
| Opulant Pharmaceuticals Pvt Ltd | +91-8105130349 +91-8105130349 | Telangana, India | 66 | 58 | Inquiry |
| Swati Spentose Pvt Ltd | +91-2261505232 +91-2261505232 | Maharashtra, India | 44 | 58 | Inquiry |
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| Apionex Pharma Pvt Ltd | +91-9773830459 +91-9819236256 | Maharashtra, India | 26 | 58 | Inquiry |
| Molsyns Research | +91-9586858886 +91-9586858886 | Gujarat, India | 418 | 58 | Inquiry |
| Chemixl Aromatiq Pvt Ltd | +91-9824173530 +91-9687606466 | Gujarat, India | 16 | 58 | Inquiry |
| Otto Chemie Pvt. Ltd. | +91 9820041841 | Mumbai, India | 5873 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Mehta Pharmaceutical Industries | 58 |
| KARPSCHEM LABORATORIES | 58 |
| PANCHSHEEL ORGANICS LTD | 58 |
| Opulant Pharmaceuticals Pvt Ltd | 58 |
| Swati Spentose Pvt Ltd | 58 |
| Ralington Pharma | 58 |
| Apionex Pharma Pvt Ltd | 58 |
| Molsyns Research | 58 |
| Chemixl Aromatiq Pvt Ltd | 58 |
| Otto Chemie Pvt. Ltd. | 58 |
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