PACAP38
- CAS No.
- 137061-48-4
- Chemical Name:
- PACAP38
- Synonyms
- Pacap;ADCYAP1;PACAP-38;Peptide pacap;PACAP 38, OVINE;PACAP-38 HUMAN, SHEEP;PACAP-38 (HUMAN, OVINE, RAT);Rabbit Anti-PACAP-38 antibody;PACAP (1-38), HUMAN, OVINE, RAT;PACAP (1-38) (HUMAN, SHEEP, RAT)
- CBNumber:
- CB5698835
- Molecular Formula:
- C203H331N63O53S1
- Molecular Weight:
- 4534.26
- MOL File:
- Mol file
- Modify Date:
- 2024/7/2 8:55:11
| RTECS | TO7345000 |
|---|---|
| storage temp. | -20°C |
| form | White to off-white solid |
| color | White to off-white |
| Water Solubility | Soluble to 0.90 mg/ml in water |
| Sequence | H-His-Ser-Asp-Gly-Ile-Phe-Thr-Asp-Ser-Tyr-Ser-Arg-Tyr-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Ala-Ala-Val-Leu-Gly-Lys-Arg-Tyr-Lys-Gln-Arg-Val-Lys-Asn-Lys-NH2 |
PACAP38 price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 05-23-2150 | PACAP 38, Ovine - CAS 137061-48-4 - Calbiochem More active than vasoactive intestinal peptide (VIP) in stimulating adenylate cyclase (EC?? = 7 nM). | 137061-48-4 | .1MG | ₹13050.01 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | A1439 | Pituitary adenylate cyclase activating polypeptide-38 | 137061-48-4 | 0.1MG | ₹26781.05 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 05-23-2150 | PACAP 38, Ovine - CAS 137061-48-4 - Calbiochem More active than vasoactive intestinal peptide (VIP) in stimulating adenylate cyclase (EC?? = 7 nM). | 137061-48-4 | 1MG | ₹65550 | 2022-06-14 | Buy |
PACAP38 Chemical Properties,Uses,Production
Uses
Pituitary adenylate cyclase activating polypeptide-38 has been used to test its effect in stimulating the formation of cyclic AMP hypothalamus and cerebral cortex slices of chicken and to treat glioblastoma cells (U87MG) in cell migration assay to test its anti-invasive effects.
General Description
Pituitary adenylate cyclase activating polypeptide-38 (PACAP38) is mapped to human chromosome 18. 27-residue-amidated fragment (PACAP27) comprises another isoform. The PACAP38 is major isoform associated with mammals.
Biological Activity
Endogenous neuropeptide showing considerable homology with vasoactive intestinal peptide (VIP). Potently stimulates adenylyl cyclase.
Structure and conformation
PACAP38, consisting of 38 aa residues, was the first
isolated, followed by PACAP27, lacking 11 aa residues
from the C-terminal of PACAP38. The C-terminal of both
PACAPs was amidated. PACAP belongs to the secretin/
glucagon superfamily, and its closest member is the vasoactive intestinal polypeptide (VIP), which shows 68% aa
sequence identity. Human PACAPs are derived from a
176-aa residue precursor, located in the C-terminus, next
to the PACAP-related peptide (PRP) . The
PACAP precursor is cleaved by various prohormone convertases (PCs) to generate PACAP27 or PACAP38. From
the evolutionary aspect of the superfamily, the ancestral
peptide emerged about 700 million years ago, and
PACAP was established by gene duplication, exon duplication, and exon deletion. The PACAP sequence is well
conserved in vertebrates, and is perfectly conserved in
mammals. Stingray PACAP has 44 aa residues with two predicted processing sites, suggesting that
the processing site of preproPACAP shows diversity in
species. Human PACAP27, theoretical Mr 3147.6, pI 9.70;
human PACAP38, theoretical Mr 4534.3, pI 10.41.
PACAP is freely soluble in water and ethanol. PACAP
solution in water is unstable at 4°C, but is stable for a year
at -80°C at 0.1mM.
PACAP38 Preparation Products And Raw materials
Raw materials
Preparation Products
PACAP38 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Shanghai Getian Industrial Co., LTD | +86-15373193816 +86-15373193816 | China | 269 | 58 | Inquiry |
| Alpha Biopharmaceuticals Co., Ltd | +86-15542445688 | China | 888 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29898 | 58 | Inquiry |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | China | 39916 | 58 | Inquiry |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-519-519-85557386 | China | 11506 | 58 | Inquiry |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 24639 | 58 | Inquiry |
| Baoji Guokang Bio-Technology Co., Ltd. | 0917-3909592 13892490616 | China | 9322 | 58 | Inquiry |
| Baoji Guokang Healthchem co.,ltd | +8615604608665 15604608665 | CHINA | 9427 | 58 | Inquiry |
| BOC Sciences | 16314854226; +16314854226 | United States | 19743 | 58 | Inquiry |
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