COLIVELIN

CAS No.: 867021-83-8

Chemical Name:: COLIVELIN

Synonyms: COLIVELIN;Colivelin (human);SALLRSIPAPAGASRLLLLTGEIDLP;SER-ALA-LEU-LEU-ARG-SER-ILE-PRO-ALA-PRO-ALA-GLY-ALA-SER-ARG-LEU-LEU-LEU-LEU-THR-GLY-GLU-ILE-ASP-LEU-PRO;H-SER-ALA-LEU-LEU-ARG-SER-ILE-PRO-ALA-PRO-ALA-GLY-ALA-SER-ARG-LEU-LEU-LEU-LEU-THR-GLY-GLU-ILE-ASP-LEU-PRO-OH;Amyloid-β,β-amyloid peptide,STAT,Colivelin,Inhibitor,inhibit,disease,Neuroprotectant,Abeta,ischemic,brain,neurological,alzheimer,injury;Colivelin trifluoroacetate salt H-Ser-Ala-Leu-Leu-Arg-Ser-Ile-Pro-Ala-Pro-Ala-Gly-Ala-Ser-Arg-Leu-Leu-Leu-Leu-Thr-Gly-Glu-Ile-Asp-Leu-Pro-OH trifluoroacetate salt;L-Proline, L-seryl-L-alanyl-L-leucyl-L-leucyl-L-arginyl-L-seryl-L-isoleucyl-L-prolyl-L-alanyl-L-prolyl-L-alanylglycyl-L-alanyl-L-seryl-L-arginyl-L-leucyl-L-leucyl-L-leucyl-L-leucyl-L-threonylglycyl-L-α-glutamyl-L-isoleucyl-L-α-aspartyl-L-leucyl-

CBNumber:: CB4795124

Molecular Formula:: C119H206N32O35

Molecular Weight:: 2645.15

MOL File:: 867021-83-8.mol

Modify Date:: 2024/5/28 19:59:05

Request For Quotation

COLIVELIN Properties

Density	1.42±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	insoluble in DMSO; insoluble in EtOH; ≥15 mg/mL in H2O
form	solid
color	White
Water Solubility	Soluble to 1 mg/ml in 20% ethanol / water

COLIVELIN Chemical Properties,Uses,Production

Description

Colivelin is a potent synthetic peptide activator of STAT3 that has neuroprotective activity. It protects approximately 50 and 100% of mouse primary cortical neurons from cell death induced by amyloid β (1-43) (Aβ43) when used at concentrations of 10 and 100 fM, respectively. Colivelin protects against cell death induced by V642I-APP in a CaM kinase IV (CaMKIV) and STAT3-dependent manner. It increases STAT3 phosphorylation in vitro and in vivo, an effect that correlates with improvements in working memory. Colivelin (10 pmol every six days) rescues deficits in spatial working memory in a mouse model of Alzheimer’s disease induced by intracerebroventricular injection of Aβ25-35. It also improves motor performance and prolongs survival in a mouse model of amyotrophic lateral sclerosis (ALS).

Uses

Colivelin is a peptide that offers neuroprotective effects against Alzheimer''s Disease (AD). It is also an activator of STAT3, a transcription factor involved with the JAK2/STAT3 pathway. Aberration in this pathway is linked to the pathogenesis of AD. Neuroprotective product.

COLIVELIN Preparation Products And Raw materials

Raw materials

Preparation Products

COLIVELIN Suppliers

Global( 94)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Hebei Kangcang new material Technology Co., LTD	+8615713292910	China	341	58	Inquiry
Strong peptide cross-border e-commerce Co. LTD	+undefined13930052870	China	84	58	Inquiry
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	China	10312	58	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29826	58	Inquiry
BOC Sciences	16314854226; +16314854226	United States	19743	58	Inquiry
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	China	10522	58	Inquiry
Chengdu Youngshe Chemical Co., Ltd.	+8618108235634	China	2345	58	Inquiry
Hebei Miaoyin Technology Co.,Ltd	+86-17367732028 +86-17367732028	China	3582	58	Inquiry
Nanjing TGpeptide	+86-13347807150 +86-13347807150	China	3279	58	Inquiry
Zhejiang Hangyu API Co., Ltd	+8617531972939	China	2944	58	Inquiry

Supplier	Advantage
Hebei Kangcang new material Technology Co., LTD	58
Strong peptide cross-border e-commerce Co. LTD	58
Shenzhen Nexconn Pharmatechs Ltd	58
career henan chemical co	58
BOC Sciences	58
Zhejiang J&C Biological Technology Co.,Limited	58
Chengdu Youngshe Chemical Co., Ltd.	58
Hebei Miaoyin Technology Co.,Ltd	58
Nanjing TGpeptide	58
Zhejiang Hangyu API Co., Ltd	58

COLIVELIN Spectrum

COLIVELIN(867021-83-8)MS

867021-83-8(COLIVELIN)Related Search:

Tetanus toxin (830-843) PYR-LEU-THR-PHE-THR-SER-SER-TRP-GLY-NH2 PACAP38 NEUROKININ A L-Leu-Leu-Leu

COLIVELIN

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COLIVELIN H-SER-ALA-LEU-LEU-ARG-SER-ILE-PRO-ALA-PRO-ALA-GLY-ALA-SER-ARG-LEU-LEU-LEU-LEU-THR-GLY-GLU-ILE-ASP-LEU-PRO-OH Colivelin (human) SER-ALA-LEU-LEU-ARG-SER-ILE-PRO-ALA-PRO-ALA-GLY-ALA-SER-ARG-LEU-LEU-LEU-LEU-THR-GLY-GLU-ILE-ASP-LEU-PRO L-Proline, L-seryl-L-alanyl-L-leucyl-L-leucyl-L-arginyl-L-seryl-L-isoleucyl-L-prolyl-L-alanyl-L-prolyl-L-alanylglycyl-L-alanyl-L-seryl-L-arginyl-L-leucyl-L-leucyl-L-leucyl-L-leucyl-L-threonylglycyl-L-α-glutamyl-L-isoleucyl-L-α-aspartyl-L-leucyl- Colivelin trifluoroacetate salt H-Ser-Ala-Leu-Leu-Arg-Ser-Ile-Pro-Ala-Pro-Ala-Gly-Ala-Ser-Arg-Leu-Leu-Leu-Leu-Thr-Gly-Glu-Ile-Asp-Leu-Pro-OH trifluoroacetate salt Amyloid-β,β-amyloid peptide,STAT,Colivelin,Inhibitor,inhibit,disease,Neuroprotectant,Abeta,ischemic,brain,neurological,alzheimer,injury SALLRSIPAPAGASRLLLLTGEIDLP 867021-83-8 C119H206N32O35 Amyloid beta-peptide and related