Tanshinone IIA
- CAS No.
- 568-72-9
- Chemical Name:
- Tanshinone IIA
- Synonyms
- Tanshinone 2A;tanshiones;SweetOrange;Tanshine II;Tanshinone B;ANSHINONE ⅡA;Tanshionesiia;TANSHINONE A;2A tanshinone;ATanshinoneⅡA
- CBNumber:
- CB5705548
- Molecular Formula:
- C19H18O3
- Molecular Weight:
- 294.34
- MOL File:
- 568-72-9.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/4/24 20:14:54
| Melting point | 196.0 to 200.0 °C |
|---|---|
| Boiling point | 480.7±44.0 °C(Predicted) |
| Density | 1.209±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | methanol: soluble5mg/mL, clear, red-orange to red |
| form | powder, red |
| color | Orange |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
| InChIKey | HYXITZLLTYIPOF-UHFFFAOYSA-N |
| LogP | 4.925 (est) |
| CAS DataBase Reference | 568-72-9(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Safety Statements | 24/25 |
|---|---|
| WGK Germany | 3 |
| RTECS | SF8282695 |
| HS Code | 29321900 |
Tanshinone IIA price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | T4952 | Tanshinone IIA ≥97% (HPLC) | 568-72-9 | 5MG | ₹10013.13 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | T4952 | Tanshinone IIA ≥97% (HPLC) | 568-72-9 | 25MG | ₹35776.63 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 51704 | Tanshinone IIA analytical standard | 568-72-9 | 10MG | ₹14148.28 | 2022-06-14 | Buy |
| TCI Chemicals (India) | T2987 | Tanshinone IIA | 568-72-9 | 10MG | ₹5000 | 2022-05-26 | Buy |
| TCI Chemicals (India) | T2987 | Tanshinone IIA | 568-72-9 | 50MG | ₹18200 | 2022-05-26 | Buy |
Tanshinone IIA Chemical Properties,Uses,Production
Description
Tanshinone IIA mainly exists in the roots of Salvia miltiorrhiza Bge. Traditional Chinese medicine Danshen, slightly cold and bitter, is often used for activating blood circulation and eliminating stasis in Chinese medicine. It can also promote blood circulation, open the energy channels, calm the heart, cool the blood, relieve swelling, remove twinge in the heart and stomach, and remove carbuncle and erysipelas. It is classified as high grade in Shen Nong’s Herbal Classic. It has been used as a traditional Chinese medicine in clinical practice for thousands of years. And it is not only recorded in the leading medical works through the ages but also in CP and USP.
Chemical Properties
Orange powder
Physical properties
Appearance: brick-red crystalline powder. Melting point: 209–210?°C. Solubility: absorbs moisture easily, very soluble in hot water, slightly soluble in methanol or ethanol, and practically insoluble in chloroform
History
The study of the chemical composition of Salvia miltiorrhiza began in the 1930s. Japanese scholars first extracted three kinds of liposoluble components from Danshen. They are tanshinones I, II, and III.
Uses
Tanshinone IIA is a derivative of Tanshinone and acts as a potential inhibitor of tumor growth in vivo. Also maintains vasodilating activity in vivo.
Pharmacology
Long-term researches show that tanshinone exhibits a variety of pharmacological effects, such as the protection of the cardiovascular system, anti-infective effects, and antioxidant effects. As for the domestic pharmacological study of tanshinone IIA, it was first started in the Shanghai Institute of Chinese Medicine. Professor Ding Guangsheng discussed the cardiovascular effects of tanshinone IIA.?He found that intraperitoneal injection of tanshinone IIA sodium sulfonate (200?mg/kg) significantly prolonged the survival time of mice under hypoxia atmosphere, and an increase in cardiac output was observed in a dog under anesthesia with a one-time intravenous injection of 20? mg/kg . In recent years, the mechanism of tanshinone IIA is increasingly brought to further research. Tanshinone IIA can increase the activity of superoxide dismutase (SOD) and interfere with the pathological process of many diseases, especially in cardiovascular diseases. It can attenuate the damages from the reactive oxygen species to vascular endothelial cells, lower the risk of atherosclerosis, and reduce the formation of atheromatous plaque. tumor cells and the expression of various genes connected with the proliferation, differentiation, and apoptosis of tumor cells. It may also have something to do with the inhibition of telomerase activity in tumor cells, changes in antigen expression on tumor cell surface, etc.
Clinical Use
Tanshinone IIA is a diterpenoid quinone liposoluble ingredient of high content, and its chemical structure is the most representative in Danshen. In addition to tanshinone IIA sodium sulfonate, there are a variety of preparations of Salvia common ketone used clinically, such as tanshinone tablets, tanshinone capsules, tanshinone injection, Danshen Shuxin capsule, compound Danshen soft capsules, and compound Danshen particles.
Cytotoxicity
IC50 (μg/mL): 0.59 (A549), 0.81 (TOV-21G) and 1.9 (MIAPaCa-2), NS (MV-3)(Chang et al. 2013; Fronza et al. 2011).
IC50 (μg/mL): 2.97 (HeLa), 2.71 (KB-3-1),>2.94 (NCI-H460), 2.62 (PC3), 2.94(MCF-7), 1.62 (K562)(Wu et al. 2014)
Tanshinone IIA Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | China | 12460 | 58 | Inquiry |
| Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 | China | 1000 | 58 | Inquiry |
| BINBO BIOLOGICAL CO.,LTD | +8618629063126 | China | 346 | 58 | Inquiry |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | China | 16209 | 58 | Inquiry |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | China | 21675 | 55 | Inquiry |
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