Geneticin

Geneticin Properties

storage temp.	2-8°C
solubility	H₂O: 50 mg/mL
form	white powder
color	white to off-white
optical activity	[α]/D (Specific Rotation: +104.4o (c=0.3% in H2O at 26oC))
Water Solubility	soluble
Stability	Hygroscopic
InChIKey	QNQZPJLBGRQFDD-ZLRXUJDMSA-N

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS08
Signal word	Danger
Hazard statements	H317-H334
Precautionary statements	P261-P272-P280-P284-P302+P352-P333+P313
Hazard Codes	Xn,Xi
Risk Statements	20/21/22-36/37/38-42/43
Safety Statements	22-24/25-36/37-23-36-26-45
WGK Germany	3
RTECS	CB9378500
HS Code	29419090

Geneticin price More Price(20)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	G8168	G 418 disulfate salt solution 50?mg/mL in H2O, 0.1 μm filtered, BioReagent, suitable for cell culture	108321-42-2	10ML	₹12156.48	2022-06-14	Buy
Sigma-Aldrich(India)	G8168	G 418 disulfate salt solution 50?mg/mL in H2O, 0.1 μm filtered, BioReagent, suitable for cell culture	108321-42-2	50ML	₹41297.38	2022-06-14	Buy
Sigma-Aldrich(India)	G8168	G 418 disulfate salt solution 50?mg/mL in H2O, 0.1 μm filtered, BioReagent, suitable for cell culture	108321-42-2	100ML	₹59201.93	2022-06-14	Buy
Sigma-Aldrich(India)	G5013	G 418 disulfate salt potency: ≥720?μg per mg (dried basis)	108321-42-2	250MG	₹2662.95	2022-06-14	Buy
Sigma-Aldrich(India)	G5013	G 418 disulfate salt potency: ≥720?μg per mg (dried basis)	108321-42-2	1G	₹8367.73	2022-06-14	Buy

Product number	Packaging	Price	Buy
G8168	10ML	₹12156.48	Buy
G8168	50ML	₹41297.38	Buy
G8168	100ML	₹59201.93	Buy
G5013	250MG	₹2662.95	Buy
G5013	1G	₹8367.73	Buy

Geneticin Chemical Properties,Uses,Production

Description

Geneticin (also known as G418, G418 sulfate) is an aminoglycoside antibiotic similar in structure to gentamicin B1, produced by Micromonospora rhodorangea. Geneticin blocks polypeptide synthesis by inhibiting the elongation step in both prokaryotic and eukaryotic cells and is commonly used in laboratory research to select genetically engineered cells. Resistance to Geneticin is conferred by the neo gene from Tn5 encoding an aminoglycoside 3'-phosphotransferase, APH 3'II.

Chemical Properties

white to off-white powder

Uses

Geneticin is an aminoglycoside antibiotic similar in structure to gentamicin used for selection and maintenance of prokaryotic and eukaryotic cells. Optimal concentrations for selection and maintenance vary by cell lines. Bacteria and algae require 5 μg/mL or less while animal cells may require 300-500 μg/mL. It is also used to membrane-permeant allosteric effector of hemoglobin therapeutic in cardiovascular diseases and cancer.

Application

Geneticin's most common application is in molecular biology as a selection agent. Geneticin(G418 sulfate) is toxic to bacteria, yeast, protozoa, helminths, and mammalian cells. Resistance is conferred by one of two dominant genes of bacterial origin which can be expressed in eukaryotic cells. G418 is water soluble and can be stored at room temperature for as long as 1 year. Aqueous solutions should be stored frozen. The amount of G418 required for selection will vary with each cell type and growth cycle. Although cells that are multiplying will be affected sooner than those that are not, cells that are in log phase will still require 3 to 7 days for selection. In general, the amount of G418 required for selection of mammalian cells is 400 mg/ml and 200 mg/ml for maintenance.

General Description

The optimal concentration of G418 for selection of resistance will vary according to the organism and/or cell type under investigation. In general, the concentration of active drug required for selection is as follows: Dictyostelium sp.: 10-100 μg/ml Plant cells: 10-100 μg/ml Yeast cells: 0.5-1.0 μg/ml Mammalian cells: 0.1-2.0 μg/ml

Mode of action

Geneticin works by blocking polypeptide synthesis by preventing the elongation step within eukaryotic cells.
Resistance: Resistance to Geneticin is conferred through the NPTll gene in plant cells and the NEO gene in mammalian cells, which encodes aminoglycoside 3'-phosphotransferase.
Action: Geneticin functions by causing a chain of nonsense mutations during translation, ultimately resulting in inhibition of polypeptide synthesis and protein elongation.

Geneticin Preparation Products And Raw materials

Raw materials

Preparation Products

Geneticin Suppliers

Global( 431)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6773	58	Inquiry
Triveni chemicals	08048762458	New Delhi, India	6093	58	Inquiry
Maxcell Systems Pvt. Ltd.	08046046154	Karnataka, India	8	58	Inquiry
Ayonex Labs Private Limited	08045911767	Punjab, India	12	58	Inquiry
Pharma Affiliates	172-5066494	Haryana, India	6761	58	Inquiry
TCI Chemicals (India) Pvt. Ltd.	1800 425 7889	New Delhi, India	6778	58	Inquiry
Sisco Research Laboratories Pvt. Ltd.	+91-22-4268 5800	Mumbai, India	4317	58	Inquiry
Sisco Resech Laboratories Private Limited	+91-22-4268 5800	Mumbai, India	655	58	Inquiry

Supplier	Advantage
A.J Chemicals	58
CLEARSYNTH LABS LTD.	58
Pharmaffiliates Analytics and Synthetics P. Ltd	58
Triveni chemicals	58
Maxcell Systems Pvt. Ltd.	58
Ayonex Labs Private Limited	58
Pharma Affiliates	58
TCI Chemicals (India) Pvt. Ltd.	58
Sisco Research Laboratories Pvt. Ltd.	58
Sisco Resech Laboratories Private Limited	58

Geneticin Spectrum

Geneticin(108321-42-2)MS

108321-42-2(Geneticin)Related Search:

D-Glucosamine sulfate Sodium sulfate sulfate Glucosamine sulfate 4-Aminotetrahydropyran

(R)-2-Aminocyclohenanol G418 TRANS-2-AMINOCYCLOHEXANOL HYDROCHLORIDE 1,3-Diaminocyclohexane TRANS-1,2-CYCLOHEXANEDIOL

PROPYLENE GLYCOL BUTYL ETHER 1-AMINO-3,3-DIETHOXYPROPANE 2-Aminocyclohexanol trans-4-Aminocyclohexanol 3-(CYCLOHEXYLOXY)PROPAN-1-AMINE

3-AMINO-4-METHYL-PENTAN-1-OL 3-Amino-cyclohexanol Cyclohexanol, 2-amino-, (1S,2S)-

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TRYPSIN INHIBITOR SOYBEAN REAGENT GRADE G-418 disulfate,Geneticin Geneticin Disulfate (G418), Antibiotic for Culture Media Use Only Antibiotic G418 Geneticin® 2-[4,6-diamino-3-[3-amino-4,5-dihydroxy-6-(1-hydroxyethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol,sulfuric acid G 418 Sulfate, Sterile-Filtered Aqueous Solution, Cell Culture Tested D-Streptamine, O-2-amino-2,7-dideoxy-D-glycero-α-D-gluco-heptopyranosyl-(1→4)-O-[3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl-(1→6)]-2-deoxy-, sulfate (1:2) Geneticin (G418 Sulfate) ANTIBIOTIC G-418 SULFATE G-418 SULPHATE G418 SULFATE GENETICIN G418 SOLUTION G418 DISULFATE CELL CULTURE TESTED G418 DISULFATE PLANT CELL CULTURE TESTED G418, DISULFATE SALT, BIOTECHNOLOGY PERFORMANCE CERTIFIED GENETICIN DISULFATE CELL CULTURE TESTED GENETICIN SOLUTION CELL CULTURE TESTED GENETICIN DISULFATE G418 SULFATE CELL CULTURE TESTED G 418 Disulfate Aqueous Solution G418 SULFATE (GENETICIN DISULFATE) G 418 Sulfate, cell culture tested G 418 solution disulfate salt G418 sulfateGeneticin®: G418 sulfate(Geneticin)>600U/mg G-418,Geneticin Geneticine disulfate (G 418) G 418 disulfate salt,>=650 U/Mg 620u/Mg Geneticin Sulfate USP G418 disulfate salt, for biocheMistry GeneticinSulfate/G418Sulfate Geneticinedisulfate G418 sulfate, for biochemistry G-418.SulfateSolid g 418disulfate salt solution Geneticin sulfate. Geneticin disulfate saltPotency ≥ 700 ug/mg (anhydrous basis) ) 50mg/ml Solution, Sterile-filtered G 418 disulfate salt, potency: ≥650 μg per mg G-418 disulfate (Geneticin sulfate) G 418 Sulfate, Cell Culture Tested - CAS 108321-42-2 - Calbiochem G 418 Sulfate, Sterile-Filtered Aqueous Solution, Cell Culture Tested - CAS 108321-42-2 - Calbiochem GENETICIN SULFATE;ANTIBIOTIC G-418 SULFATE 50mg/ml G-418 Sulfate Solution, Animal-derived-free G418Disulfate> Male clove extract 418 DisuL G418 DisuL (2R,3S,4R,5R,6S)-5-Amino-6-(((1R,2S,3S,4R,6S)-4,6-diamino-3-(((2R,3R,4R,5R)-3,5-dihydroxy-5-methyl-4-(methylamino)tetrahydro-2H-pyran-2-yl)oxy)-2-hydroxycyclohexyl)oxy)-2-((R)-1-hydroxyethyl)tetrahydro-2H-pyran-3,4-diol bis(sulfate) Geneticin(G 418 disulfate salt) 2-[4,6-diamino-3-[3-amino-4,5-dihydroxy-6-(1-hydroxyethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol,sulfuricaci G418 Sulfate (>700U/mg) USPGrade G 418 disulfate salt,≥65 U/mg G-418 Sulphate (Geneticin) extrapure G-418 Sulphate (Geneticin) for tissue culture 17alpha-Epoxypregnenolone