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(-)-Bicucullinemethiodide

(-)-Bicucullinemethiodide Structure
CAS No.
40709-69-1
Chemical Name:
(-)-Bicucullinemethiodide
Synonyms
(-)-Bicuculline methiodide;(+)-Bicuculline methiodide;(-)-Bicuculline methiodide, GABAA antagonist;( ) Bicuculline methiodide,()Bicuculline methiodide;(-)-Bicuculline methiodide (mM/ml), GABAA antagonist;(-)-Bicuculline methiodide DISCONTINUED. offer B382505;(5S)-5-[(6R)-6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl]-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium iodide;[R-(R,S)]-5-(6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium iodide;1,3-Dioxolo(4,5-G)isoquinolinium, 5-((6R)-6,8-dihydro-8-oxofuro(3,4-E)-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-, iodide, (5S)-;1,3-Dioxolo(4,5-G)isoquinolinium, 5-(6,8-dihydro-8-oxofuro(3,4-E)-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-, iodide, (R-(R*,S*))-
CBNumber:
CB61075225
Molecular Formula:
C21H20INO6
Molecular Weight:
0
MOL File:
40709-69-1.mol
Modify Date:
2024/10/28 16:48:35
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(-)-Bicucullinemethiodide Properties

RTECS JI4904100
storage temp. Store at RT
solubility H2O: soluble10mg/mL, almost clear, greenish-yellow
form Pale yellow solid.
color Yellow
optical activity [α]/D -117±7°, c = 1 in chloroform
BRN 5419649

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS06,GHS09
Signal word  Warning
Hazard statements  H301-H311-H330-H400
Precautionary statements  P301+P310a-P304+P340-P320-P330-P405-P501a
WGK Germany  3
HazardClass  6.1

(-)-Bicucullinemethiodide price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) 14343 1(S),9(R)-(−)-Bicuculline methiodide ≥95.0% (HPCE) 40709-69-1 10MG ₹5412.5 2022-06-14 Buy
Sigma-Aldrich(India) 14343 1(S),9(R)-(−)-Bicuculline methiodide ≥95.0% (HPCE) 40709-69-1 50MG ₹22137.13 2022-06-14 Buy
Product number Packaging Price Buy
14343 10MG ₹5412.5 Buy
14343 50MG ₹22137.13 Buy

(-)-Bicucullinemethiodide Chemical Properties,Uses,Production

Uses

1(S),9(R)-(-)-Bicuculline methiodide has been used as a gamma-aminobutyric acid (GABA) antagonist to block inhibition in the semicoronal slices. It has also been used for the preparation of organotypic hippocampal slice cultures (OHSCs).

General Description

Bicuculline is a phthalide isoquinoline alkaloid, which is extracted from Dicentra cucullaria. It acts as an acetylcholinesterase?inhibitor. Bicuculline inhibits slow afterhyperpolarization (AHP).

Biological Activity

Methiodide form of classical GABA A receptor antagonist (+)-bicuculline ([R-(R*,S*)]-6-(5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)furo[3,4-e]-1,3-benzodioxol-8(6H)-one ). More water-soluble and stable. Non-GABA receptor-mediated actions reported, including actions on calcium-dependent potassium channels.

(-)-Bicucullinemethiodide Preparation Products And Raw materials

Raw materials

Preparation Products

(-)-Bicucullinemethiodide Suppliers

Global( 22)Suppliers
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TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 32161 58 Inquiry
Aladdin Scientific +1-+1(833)-552-7181 United States 52924 58 Inquiry
RD International Technology Co., Limited 18024082417 China 9266 58 Inquiry
Henan Alpha Chemical Co., Ltd. 0371-55013243 15324716602 China 10033 58 Inquiry
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 China 9806 58 Inquiry
TargetMol Chemicals Inc. 4008200310 China 24644 58 Inquiry
Abcam +1 (877) 774-8286 United States 6000 50 Inquiry
Service Chemical Inc. 888-895-6920 Germany 6350 71 Inquiry
BIOMOL INTERNATIONAL, LP (800) 942-0430 United States 1499 77 Inquiry
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037 China 15839 69 Inquiry
Supplier Advantage
TargetMol Chemicals Inc. 58
Aladdin Scientific 58
RD International Technology Co., Limited 58
Henan Alpha Chemical Co., Ltd. 58
Shanghai EFE Biological Technology Co., Ltd. 58
TargetMol Chemicals Inc. 58
Abcam 50
Service Chemical Inc. 71
BIOMOL INTERNATIONAL, LP 77
3B Pharmachem (Wuhan) International Co.,Ltd. 69

40709-69-1((-)-Bicucullinemethiodide)Related Search:

(Z)-3-[(AMINOIMINOMETHYL)THIO]PROP-2-ENOIC ACID SULFATE THIOCOLCHICOSIDE MUSCIMOL (+)-Bicuculline
[R-(R,S)]-5-(6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium iodide 1,3-Dioxolo(4,5-G)isoquinolinium, 5-((6R)-6,8-dihydro-8-oxofuro(3,4-E)-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-, iodide, (5S)- 1,3-Dioxolo(4,5-G)isoquinolinium, 5-(6,8-dihydro-8-oxofuro(3,4-E)-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-, iodide, (R-(R*,S*))- (5S)-5-[(6R)-6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl]-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium iodide (-)-Bicuculline methiodide (-)-Bicuculline methiodide DISCONTINUED. offer B382505 ( ) Bicuculline methiodide,()Bicuculline methiodide (5S)-6,6-Dimethyl-5-{12-oxo-3,5,11-trioxatricyclo[7.3.0.02,]dodeca-1(9),2(6),7-trien-10-yl}-2H,5H,6H,7H,8H-[1,3]dioxolo[4,5-g]isoquinolin-6-ium iodide (+)-Bicuculline methiodide (-)-Bicuculline methiodide, GABAA antagonist (-)-Bicuculline methiodide (mM/ml), GABAA antagonist 40709-69-1 GABA/Glycine receptor