ChemicalBook > Product Catalog >API >Antipyretic analgesics >Analgesics >(+)-Bicuculline

(+)-Bicuculline

CAS No.: 485-49-4

Chemical Name:: (+)-Bicuculline

Synonyms: NSC 3219;bicucullin;NSC 32192);Bucuculline;BICUCULLINE;D-BICUCULLINE;(+)-BICUCULINE;(+)-BICUCULLINE;PLUS-BICUCULLINE;(+)-Bicuculline,98%

CBNumber:: CB3418662

Molecular Formula:: C20H17NO6

Molecular Weight:: 367.35

MOL File:: 485-49-4.mol

Modify Date:: 2023/6/30 15:45:59

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(+)-Bicuculline Properties

Melting point	193-197 °C
alpha	D25 +130.5° (CHCl3)
Boiling point	497.92°C (rough estimate)
Density	1.3694 (rough estimate)
refractive index	1.5600 (estimate)
storage temp.	2-8°C
solubility	Benzene, Chloroform, DMSO, Ethyl Acetate
pka	4.84(at 25℃)
form	Off-white to yellow powder.
color	Pale Yellow
optical activity	[α]20/D +126±6°, c = 1% in chloroform
λmax	325nm(lit.)
Merck	14,1203
BRN	98786
InChIKey	IYGYMKDQCDOMRE-ZWKOTPCHSA-N
CAS DataBase Reference	485-49-4(CAS DataBase Reference)
EPA Substance Registry System	Furo[3,4-e]-1,3-benzodioxol-8(6H)-one, 6-[(5S)-5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-, (6R)- (485-49-4)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06,GHS09

Signal word

Danger

Hazard statements

H300+H310+H330-H400

Precautionary statements

P260-P262-P273-P280-P302+P352+P310-P304+P340+P310

Hazard Codes

T,N,Xn

Risk Statements

23/24/25-50-36/37/38-20/21/22

Safety Statements

36/37-45-61-36-26

RIDADR

UN 1544 6.1/PG 2

WGK Germany

RTECS

LV0909840

10-23

HazardClass

6.1(b)

PackingGroup

III

HS Code

29399990

Toxicity

LD50 ipr-mus: 8480 mg/kg CUTOEX 1,199,93

NFPA 704

	0
4		0

(+)-Bicuculline price More Price(8)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	14340	(+)-Bicuculline ≥97.0% (TLC)	485-49-4	25MG	₹6884.7	2022-06-14	Buy
Sigma-Aldrich(India)	14340	(+)-Bicuculline ≥97.0% (TLC)	485-49-4	25MG	₹6884.7	2022-06-14	Buy
Sigma-Aldrich	14340	(+)-Bicuculline ≥97.0% (TLC)	485-49-4	100MG	₹11723.48	2022-06-14	Buy
Sigma-Aldrich(India)	14340	(+)-Bicuculline ≥97.0% (TLC)	485-49-4	100MG	₹11723.48	2022-06-14	Buy
Sigma-Aldrich	14340	(+)-Bicuculline ≥97.0% (TLC)	485-49-4	500MG	₹30169.28	2022-06-14	Buy

Product number	Packaging	Price	Buy
14340	25MG	₹6884.7	Buy
14340	25MG	₹6884.7	Buy
14340	100MG	₹11723.48	Buy
14340	100MG	₹11723.48	Buy
14340	500MG	₹30169.28	Buy

(+)-Bicuculline Chemical Properties,Uses,Production

Chemical Properties

Pale Yellow Solid

Uses

Alkaloid naturally occurring in the d-form. Shows GABA antagonist activity.

General Description

Bicuculline is a convulsant alkaloid. It was originally isolated from the plant Dicentra cucullaria.

Biological Activity

Classical GABA A antagonist.

Safety Profile

A poison by intraperitoneal route.When heated to decomposition it emits toxic vapors ofNOx.

Purification Methods

It crystallises from CHCl3/MeOH as plates. The crystals melt at 177o, then solidify and re-melt at 193-195o [Manske Canad J Research 21B 13 1943]. It is soluble in CHCl3, *C6H6, EtOAc but sparingly soluble in EtOH, MeOH and Et2O. [Stereochem: Blaha et al. Collect Czech Chem Commun 29 2328 1964, Snatzke et al. Tetrahedron 25 5059 1969, Pharmcol: Curtis et al. Nature 266 1222 1970, Beilstein 27 III/IV 1900].

(+)-Bicuculline Preparation Products And Raw materials

Raw materials

Preparation Products

(+)-Bicuculline Suppliers

Global( 292)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
TCI Chemicals (India) Pvt. Ltd.	1800 425 7889	New Delhi, India	6778	58	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29899	58	Inquiry
Chengdu Biopurify Phytochemicals Ltd.	+8618080483897	China	3424	58	Inquiry
Shaanxi Pioneer Biotech Co., Ltd .	+8613259417953	China	3000	58	Inquiry
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	China	39916	58	Inquiry
CONIER CHEM AND PHARMA LIMITED	+8618523575427	China	49391	58	Inquiry
Neostar United (Changzhou) Industrial Co., Ltd.	+86-519-519-85557386	China	12177	58	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	United States	19892	58	Inquiry

Supplier	Advantage
TCI Chemicals (India) Pvt. Ltd.	58
A.J Chemicals	58
CLEARSYNTH LABS LTD.	58
career henan chemical co	58
Chengdu Biopurify Phytochemicals Ltd.	58
Shaanxi Pioneer Biotech Co., Ltd .	58
Chongqing Chemdad Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
Neostar United (Changzhou) Industrial Co., Ltd.	58
TargetMol Chemicals Inc.	58

(+)-Bicuculline Spectrum

(+)-Bicuculline(485-49-4)MS (+)-Bicuculline(485-49-4)¹HNMR (+)-Bicuculline(485-49-4)¹³CNMR (+)-Bicuculline(485-49-4)IR1 (+)-Bicuculline(485-49-4)IR2

485-49-4((+)-Bicuculline)Related Search:

Kresoxim-methyl METHYL THIOPHENE-2-CARBOXYLATE Bensulfuron methyl Methylparaben Thiophanate-methyl

Methyl acrylate Methyl acetate POLY(D-LACTIDE) Methyl Parathion-methyl

Methyl bromide (-)-BICUCULLINE 1(S),9(R) METHBROMIDE,(-)-BICUCULLINE METHOBROMIDE,(-)-BICUCULLINE 1(S),9(R) METHBROMIDE,(-)-BICUCULLINE METHOBROMIDE BICUCULLINE METHYLCHLORIDE (-), [METHYL-3H],BICUCULLINE METHYLCHLORIDE (-), [METHYL-3H] (-)-BICUCULLINE METHIODIDE BICUCULLINE METHYLCHLORIDE (-), [METHYL-14C],BICUCULLINE METHYLCHLORIDE (-), [METHYL-14C]

1(s),9(r)-(-)-bicuculline methochloride,1(S),9(R)-(-)-Bicuculline methchloride,1(s),9(r)-(-)-bicuculline methochloride,1(S),9(R)-(-)-Bicuculline methchloride (-)-BICUCULLINE METHOCHLORIDE,(-)-BICUCULLINE METHOCHLORIDE (-)-BICUCULLINE METHBROMIDE

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5-g)isoquinolin-5-yl)-,(r-(r*,s*))-lo( bicucullin Bucuculline d-Bicuculline/(+)-Bicuculline D-alkali than buttoned Spirit Furo[3,4-e]-1,3-benzodioxol-8(6H)-one, 6-[(5S)-5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-, (6R)- 6-[(5S)-5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-(6R)-furo[3,4-e]-1,3-benzodioxol-8(6H)-one furo(3,4-e)-1,3-benzodioxol-8(6h)-one,6-(5,6,7,8-tetrahydro-6-methyl-1,3-dioxo (6R)-6-[(5S)-5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo[4,5-g]lisoquinolin-5-yl]furo[3,4-e]-1,3-benzodioxol-8(6H)-one NSC 3219 NSC 32192) (6R)-6-[(5S)-6-Methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-6H-furo[4,3-g][1,3]benzodioxol-8-one 1,3-Dioxolo[4,5-g]isoquinoline, furo[3,4-e]-1,3-benzodioxol-8(6H)-one deriv. Furo(3,4-e)-1,3-benzodioxol-8(6H)-one, 6-(5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo(4,5-g) isoquinolin-5-yl)-, (R-(R*,S*))- (6R)-6-[(5S)-5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]furo[3,4-e]-1,3-benzodioxol-8(6H)-one (+)-Bicuculline,98% PLUS-BICUCULLINE (+)-BICUCULLINE 1(S),9(R) (r-(r*,s*))-6-(5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo(4,5-g)isoquinolin-5-yl)-furo(3,4-e)-1,3-benzodioxol-8(6h)-one [R-(R*,S*)]-6-(5,6,7,8-TETRAHYDRO-6-METHYL-1,3-DIOXOLO[4,5-G]ISOQUINOLIN-5-YL)FURO[3,4-E]-1,3-BENZODIOXOL-8(6H)-ONE (+)-BICUCULINE (+)-BICUCULLINE BICUCULLINE D-BICUCULLINE BICUCULLINE, (+)-(P) (+)-Bicuculline, 99%, a GABAA antagonist (+)-Bicuculline > (R)-6-((S)-6-Methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-[1,3]dioxolo[4,5-e]isobenzofuran-8(6H)-one (+)-Bicuculline USP/EP/BP (+) bicuculline DISCONTINUED, offer B382500 Bicuculline (6CI, 7CI, 8CI) 485-49-4 C20H17NO6 Inhibitors chemical reagent pharmaceutical intermediate phytochemical reference standards from Chinese medicinal herbs (TCM). standardized herbal extract Alkaloids Intermediates & Fine Chemicals Pharmaceuticals GABA/Glycine receptor GABA