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ChemicalBook > Product Catalogue >API >Antipyretic analgesics >Analgesics >(+)-Bicuculline

(+)-Bicuculline

(+)-Bicuculline Structure
  • ₹3800 - ₹30169.28
  • Product name: (+)-Bicuculline
  • CAS: 485-49-4
  • MF: C20H17NO6
  • MW: 367.35
  • EINECS:207-619-7
  • MDL Number:MFCD00005006
  • Synonyms:5-g)isoquinolin-5-yl)-,(r-(r*,s*))-lo( ;bicucullin ;Bucuculline;d-Bicuculline/(+)-Bicuculline;D-alkali than buttoned Spirit;Furo[3,4-e]-1,3-benzodioxol-8(6H)-one, 6-[(5S)-5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-, (6R)-;6-[(5S)-5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-(6R)-furo[3,4-e]-1,3-benzodioxol-8(6H)-one;furo(3,4-e)-1,3-benzodioxol-8(6h)-one,6-(5,6,7,8-tetrahydro-6-methyl-1,3-dioxo
Price8 Properties Safety Information Description
8 prices
Selected condition：

Brand

  • Sigma-Aldrich
  • TCI Chemicals (India)
  • Sigma-Aldrich(India)

Package

  • 25MG
  • 100MG
  • 500MG
  • ManufacturerSigma-Aldrich
  • Product number14340
  • Product description(+)-Bicuculline ≥97.0% (TLC)
  • Packaging25MG
  • Price₹6884.7
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich
  • Product number14340
  • Product description(+)-Bicuculline ≥97.0% (TLC)
  • Packaging100MG
  • Price₹11723.48
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich
  • Product number14340
  • Product description(+)-Bicuculline ≥97.0% (TLC)
  • Packaging500MG
  • Price₹30169.28
  • Updated2022-06-14
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberB1890
  • Product description(+)-Bicuculline
  • Packaging25MG
  • Price₹3800
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberB1890
  • Product description(+)-Bicuculline
  • Packaging100MG
  • Price₹12300
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number14340
  • Product description(+)-Bicuculline ≥97.0% (TLC)
  • Packaging25MG
  • Price₹6884.7
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number14340
  • Product description(+)-Bicuculline ≥97.0% (TLC)
  • Packaging100MG
  • Price₹11723.48
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number14340
  • Product description(+)-Bicuculline ≥97.0% (TLC)
  • Packaging500MG
  • Price₹30169.28
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich 14340 (+)-Bicuculline ≥97.0% (TLC) 25MG ₹6884.7 2022-06-14 Buy
Sigma-Aldrich 14340 (+)-Bicuculline ≥97.0% (TLC) 100MG ₹11723.48 2022-06-14 Buy
Sigma-Aldrich 14340 (+)-Bicuculline ≥97.0% (TLC) 500MG ₹30169.28 2022-06-14 Buy
TCI Chemicals (India) B1890 (+)-Bicuculline 25MG ₹3800 2022-05-26 Buy
TCI Chemicals (India) B1890 (+)-Bicuculline 100MG ₹12300 2022-05-26 Buy
Sigma-Aldrich(India) 14340 (+)-Bicuculline ≥97.0% (TLC) 25MG ₹6884.7 2022-06-14 Buy
Sigma-Aldrich(India) 14340 (+)-Bicuculline ≥97.0% (TLC) 100MG ₹11723.48 2022-06-14 Buy
Sigma-Aldrich(India) 14340 (+)-Bicuculline ≥97.0% (TLC) 500MG ₹30169.28 2022-06-14 Buy

Properties

Melting point :193-197 °C
alpha :D25 +130.5° (CHCl3)
Boiling point :497.92°C (rough estimate)
Density :1.3694 (rough estimate)
refractive index :1.5600 (estimate)
storage temp. :2-8°C
solubility :Benzene, Chloroform, DMSO, Ethyl Acetate
pka :4.84(at 25℃)
form :Off-white to yellow powder.
color :Pale Yellow
optical activity :[α]20/D +126±6°, c = 1% in chloroform
λmax :325nm(lit.)
Merck :14,1203
BRN :98786
InChIKey :IYGYMKDQCDOMRE-ZWKOTPCHSA-N
CAS DataBase Reference :485-49-4(CAS DataBase Reference)
EPA Substance Registry System :Furo[3,4-e]-1,3-benzodioxol-8(6H)-one, 6-[(5S)-5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-, (6R)- (485-49-4)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H400 Very toxic to aquatic life Hazardous to the aquatic environment, acute hazard Category 1 Warning GHS hazard pictograms P273, P391, P501
Precautionary statements:
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P262 Do not get in eyes, on skin, or on clothing.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.

Description

Ionotropic GABAA receptors are ligand-gated ion channels that facilitate the passing of chloride ions across the cell membrane and promote an inhibitory influence on target neurons. These receptors are the major targets for benzodiazepines and related anxiolytic drugs. Bicuculline is a competitive GABAA receptor antagonist that can act as an allosteric inhibitor at GABAA receptors. At 100 μM, it blocks spontaneously opening chloride channels in the outside-out patches from the cultured cortical neurons. Bicuculline also reversibly blocks GABAA receptors on horizontal cells in the mouse retina with an IC50 value of 1.7 μM. By blocking the inhibitory action of GABA, bicuculline mimics the action of epilepsy and is widely used in experimental studies as a convulsant, inducing seizure in hippocampal or cortical neurons in prepared brain slices.

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Suppliers and manufacturers

career henan chemical co
(+)-Bicuculline
₹2.00 /1kg
(+)-Bicuculline CAS:485-49-4
TCI Chemicals (India) Pvt. Ltd. A.J Chemicals CLEARSYNTH LABS LTD.
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Shaanxi Pioneer Biotech Co., Ltd .
Chongqing Chemdad Co., Ltd
CONIER CHEM AND PHARMA LIMITED
TargetMol Chemicals Inc.
Hubei Ipure Biology Co., Ltd