(+)-Bicuculline
- ₹3800 - ₹30169.28
- Product name: (+)-Bicuculline
- CAS: 485-49-4
- MF: C20H17NO6
- MW: 367.35
- EINECS:207-619-7
- MDL Number:MFCD00005006
- Synonyms:5-g)isoquinolin-5-yl)-,(r-(r*,s*))-lo( ;bicucullin ;Bucuculline;d-Bicuculline/(+)-Bicuculline;D-alkali than buttoned Spirit;Furo[3,4-e]-1,3-benzodioxol-8(6H)-one, 6-[(5S)-5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-, (6R)-;6-[(5S)-5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-(6R)-furo[3,4-e]-1,3-benzodioxol-8(6H)-one;(+)-Bicuculline, 99%, a GABAA antagonist
5 prices
Selected condition:
Brand
- TCI Chemicals (India)
- Sigma-Aldrich(India)
Package
- 25MG
- 100MG
- 500MG
- ManufacturerTCI Chemicals (India)
- Product numberB1890
- Product description(+)-Bicuculline
- Packaging25MG
- Price₹3800
- Updated2022-05-26
- Buy
- ManufacturerTCI Chemicals (India)
- Product numberB1890
- Product description(+)-Bicuculline
- Packaging100MG
- Price₹12300
- Updated2022-05-26
- Buy
- ManufacturerSigma-Aldrich(India)
- Product number14340
- Product description(+)-Bicuculline ≥97.0% (TLC)
- Packaging500MG
- Price₹30169.28
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product number14340
- Product description(+)-Bicuculline ≥97.0% (TLC)
- Packaging100MG
- Price₹11723.48
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product number14340
- Product description(+)-Bicuculline ≥97.0% (TLC)
- Packaging25MG
- Price₹6884.7
- Updated2022-06-14
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
TCI Chemicals (India) | B1890 | (+)-Bicuculline | 25MG | ₹3800 | 2022-05-26 | Buy |
TCI Chemicals (India) | B1890 | (+)-Bicuculline | 100MG | ₹12300 | 2022-05-26 | Buy |
Sigma-Aldrich(India) | 14340 | (+)-Bicuculline ≥97.0% (TLC) | 500MG | ₹30169.28 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | 14340 | (+)-Bicuculline ≥97.0% (TLC) | 100MG | ₹11723.48 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | 14340 | (+)-Bicuculline ≥97.0% (TLC) | 25MG | ₹6884.7 | 2022-06-14 | Buy |
Properties
Melting point :193-197 °C
alpha :D25 +130.5° (CHCl3)
Boiling point :497.92°C (rough estimate)
Density :1.3694 (rough estimate)
refractive index :1.5600 (estimate)
storage temp. :2-8°C
solubility :Benzene, Chloroform, DMSO, Ethyl Acetate
form :Off-white to yellow powder.
pka :4.84(at 25℃)
color :Pale Yellow
optical activity :[α]20/D +126±6°, c = 1% in chloroform
λmax :325nm(lit.)
Merck :14,1203
BRN :98786
InChIKey :IYGYMKDQCDOMRE-ZWKOTPCHSA-N
CAS DataBase Reference :485-49-4(CAS DataBase Reference)
EPA Substance Registry System :Furo[3,4-e]-1,3-benzodioxol-8(6H)-one, 6-[(5S)-5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-, (6R)- (485-49-4)
alpha :D25 +130.5° (CHCl3)
Boiling point :497.92°C (rough estimate)
Density :1.3694 (rough estimate)
refractive index :1.5600 (estimate)
storage temp. :2-8°C
solubility :Benzene, Chloroform, DMSO, Ethyl Acetate
form :Off-white to yellow powder.
pka :4.84(at 25℃)
color :Pale Yellow
optical activity :[α]20/D +126±6°, c = 1% in chloroform
λmax :325nm(lit.)
Merck :14,1203
BRN :98786
InChIKey :IYGYMKDQCDOMRE-ZWKOTPCHSA-N
CAS DataBase Reference :485-49-4(CAS DataBase Reference)
EPA Substance Registry System :Furo[3,4-e]-1,3-benzodioxol-8(6H)-one, 6-[(5S)-5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-, (6R)- (485-49-4)
Safety Information
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Signal word: | Danger | ||||||||||||||
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Description
Ionotropic GABAA receptors are ligand-gated ion channels that facilitate the passing of chloride ions across the cell membrane and promote an inhibitory influence on target neurons. These receptors are the major targets for benzodiazepines and related anxiolytic drugs. Bicuculline is a competitive GABAA receptor antagonist that can act as an allosteric inhibitor at GABAA receptors. At 100 μM, it blocks spontaneously opening chloride channels in the outside-out patches from the cultured cortical neurons. Bicuculline also reversibly blocks GABAA receptors on horizontal cells in the mouse retina with an IC50 value of 1.7 μM. By blocking the inhibitory action of GABA, bicuculline mimics the action of epilepsy and is widely used in experimental studies as a convulsant, inducing seizure in hippocampal or cortical neurons in prepared brain slices.More related product prices
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