2-[(4-methoxyphenoxy)carbonyl-[[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-y l)ethoxy]phenyl]methyl]amino]acetic acid

CAS No.: 331741-94-7

Chemical Name:: 2-[(4-methoxyphenoxy)carbonyl-[[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-y l)ethoxy]phenyl]methyl]amino]acetic acid

Synonyms: Pargluva;BMS 298585;Muraglitazar;Amylin (8-37), amide;amylin pharmaceuticals;muraglitazar(BMS-298585);symlinDiabetes Associated Peptide (8-37), amide;N-((4-Methoxyphenoxy)carbonyl)-N-(4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benzyl)glycine;2-(((4-Methoxyphenoxy)carbonyl)(4-(2-(5-Methyl-2-phenyloxazol-4-yl)ethoxy)benzyl)aMino)acetic acid;N-[(4-Methoxyphenoxy)carbonyl]-N-[[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]methyl]glycine

CBNumber:: CB61261075

Molecular Formula:: C29H28N2O7

Molecular Weight:: 516.54

MOL File:: 331741-94-7.mol

MSDS File:: SDS

Modify Date:: 2023/9/4 15:51:00

Request For Quotation

2-[(4-methoxyphenoxy)carbonyl-[[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-y l)ethoxy]phenyl]methyl]amino]acetic acid Properties

Melting point	123-125°C
Boiling point	736.4±70.0 °C(Predicted)
Density	1.274±0.06 g/cm3(Predicted)
storage temp.	Refrigerator
solubility	Chloroform (Slightly), Methanol (Slightly)
pka	3.82±0.10(Predicted)
form	Solid
color	Off-White
EPA Substance Registry System	Glycine, N-[(4-methoxyphenoxy)carbonyl]-N-[[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]methyl]- (331741-94-7)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335-H402

Precautionary statements

P261-P264-P271-P273-P280-P302+P352-P304+P340-P305+P351+P338-P312-P321-P362+P364-P332+P313-P337+P313-P403+P233-P405-P501

NFPA 704

	0
2		0

2-[(4-methoxyphenoxy)carbonyl-[[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-y l)ethoxy]phenyl]methyl]amino]acetic acid Chemical Properties,Uses,Production

Description

Muraglitazar is a dual agonist of peroxisome proliferator-activated receptor α (PPARα) and PPARγ (EC₅₀s = 0.32 and 0.11 μM, respectively). It is selective for PPARα/γ over other nuclear receptors, including PPARδ, RXRα, RARs, estrogen receptor α (ERα), ERβ, androgen receptor (AR), and progesterone receptor (PR). Muraglitazar (50 μM) reduces the size of lipid droplets in oleic acid-treated HepaRG human hepatocytes. It reduces plasma levels of glucose, triglycerides, free fatty acids, and insulin by 54, 33, 62, and 48%, respectively, in db/db mice when administered at a dose of 10 mg/kg per day. Muraglitazar (10 mg/kg per day) reduces plasma levels of glucose, triglycerides, and cholesterol in diet-induced obese mice. Muraglitazar also inhibits LPS-induced increases in nitric oxide (NO) production and IL-6, TNF-α, and inducible nitric oxide synthase (iNOS) protein levels in J774 murine macrophages in a concentration-dependent manner. It inhibits carrageenan-induced paw edema in mice when administered at doses ranging from 12.5 to 50 mg/kg.

Chemical Properties

Off-White Solid

Uses

It is a peroxisome proliferator-activated receptor (PPAR) a/ dual agonist

2-[(4-methoxyphenoxy)carbonyl-[[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-y l)ethoxy]phenyl]methyl]amino]acetic acid Preparation Products And Raw materials

Raw materials

Preparation Products

2-[(4-methoxyphenoxy)carbonyl-[[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-y l)ethoxy]phenyl]methyl]amino]acetic acid Suppliers

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Supplier	Advantage
CLEARSYNTH LABS LTD.	58
Pharmaffiliates Analytics and Synthetics P. Ltd	58
Fuxin Pharmaceutical	58
InvivoChem	58
Aladdin Scientific	58
RD International Technology Co., Limited	58
Shaoxing Junyu Biotechnology Co., LTD	58
Zhejiang Jiekun Biotechnology Co., Ltd	58
Nantong Feiyu Biological Technology CO.,LTD	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	58

2-[(4-methoxyphenoxy)carbonyl-[[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-y l)ethoxy]phenyl]methyl]amino]acetic acid Spectrum

2-[(4-methoxyphenoxy)carbonyl-[[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-y l)ethoxy]phenyl]methyl]amino]acetic acid(331741-94-7)¹HNMR

331741-94-7(2-[(4-methoxyphenoxy)carbonyl-[[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-y l)ethoxy]phenyl]methyl]amino]acetic acid)Related Search:

2-[(4-methoxyphenoxy)carbonyl-[[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-y l)ethoxy]phenyl]methyl]amino]acetic acid CHEMBRDG-BB 7017116

N-[(4-Methoxyphenoxy)carbonyl]-N-[[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]methyl]glycine Pargluva 2-(((4-Methoxyphenoxy)carbonyl)(4-(2-(5-Methyl-2-phenyloxazol-4-yl)ethoxy)benzyl)aMino)acetic acid 2-[(4-methoxyphenoxy)carbonyl-[[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-y l)ethoxy]phenyl]methyl]amino]acetic acid BMS 298585 Muraglitazar Amylin (8-37), amide AMYLIN (8-37), AMIDE; AMYLIN PHARMACEUTICALS; MURAGLITAZAR; OXYNTOMODULIN; SYMLINDIABETES ASSOCIATED PEPTIDE (8-37), AMIDE amylin pharmaceuticals symlinDiabetes Associated Peptide (8-37), amide Glycine, N-[(4-methoxyphenoxy)carbonyl]-N-[[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]methyl]- muraglitazar(BMS-298585) N-((4-Methoxyphenoxy)carbonyl)-N-(4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benzyl)glycine 331741-94-7 C29H28N2O7 Agro Products Agonist Intermediates & Fine Chemicals Pharmaceuticals