H-MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU-OH

CAS No.: 249537-73-3

Chemical Name:: H-MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU-OH

Synonyms: VIVIT;NFAT INHIBITOR;MAGPHPVIVITGPHEE;NFAT Inhibitor-1;NFAT INHIBITOR?, >98%;NFAT Inhibitor (VIVIT peptide);NFAT Inhibitor >96% (HPLC), solid;NFAT Inhibitor,VIVIT peptide,MAGPHPVIVITGPHEE?, >98%;MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU;H-MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU-OH

CBNumber:: CB6148948

Molecular Formula:: C75H118N20O22S

Molecular Weight:: 1683.93

MOL File:: 249537-73-3.mol

MSDS File:: SDS

Modify Date:: 2024/7/2 8:55:13

Request For Quotation

H-MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU-OH Properties

Boiling point	1982.4±65.0 °C(Predicted)
Density	1.334±0.06 g/cm3(Predicted)
storage temp.	-20°C
solubility	DMSO: 15 mg/ml; Water: 10 mg/ml
form	solid
pka	3.12±0.10(Predicted)
color	White to off-white
Water Solubility	Soluble to 2 mg/ml in water
Sequence	H-Met-Ala-Gly-Pro-His-Pro-Val-Ile-Val-Ile-Thr-Gly-Pro-His-Glu-Glu-OH

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P280-P301+P312-P302+P352-P305+P351+P338
Safety Statements	22-24/25
WGK Germany	3
HS Code	2933299090

H-MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU-OH price More Price(1)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	N7032	NFAT Inhibitor >96% (HPLC), solid	249537-73-3	1MG	₹55802.88	2022-06-14	Buy

Product number	Packaging	Price	Buy
N7032	1MG	₹55802.88	Buy

H-MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU-OH Chemical Properties,Uses,Production

Description

NFAT inhibitor is a cell-permeable compound that selectively inhibits calcineurin-mediated dephosphorylation of NFAT. At 100 μM, this inhibitor effectively blocks calcineurin binding to NFAT without disrupting other calcineurin-dependent pathways, unlike the immunosuppressants cyclosporin A and FK506 which indiscriminately block all calcineurin phosphatase activity. NFAT inhibitor can disrupt NFAT-dependent expression of IL-2 and TNF-α when transfected in Jurak T cells and can prevent the activation and proliferation of T cells both in vitro (~ 43% at 1 μM using mixed lymphocyte cultures) and in vivo (10 mg/kg using C3H/HeN mice).

Uses

NFAT Inhibitor, VIVIT has been used to study the signaling pathways involved in controlling inhibitory molecules and subsequent onset of T-cell impairment.

Biochem/physiol Actions

High-affinity calcineurin-binding peptide that inhibits NFAT (Nuclear Factor of Activated T cells) activation and NFAT-dependent expression of endogenous cytokine genes in T cells.

H-MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU-OH Preparation Products And Raw materials

Raw materials

Preparation Products

H-MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU-OH Suppliers

Global( 92)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	China	10312	58	Inquiry
BOC Sciences	+1-631-485-4226	United States	19553	58	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29826	58	Inquiry
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	China	10522	58	Inquiry
Alfa Chemistry		United States	24072	58	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354	United States	19973	58	Inquiry
Hebei Miaoyin Technology Co.,Ltd	+86-17367732028 +86-17367732028	China	3582	58	Inquiry
Nanjing TGpeptide	+86-13347807150 +86-13347807150	China	3279	58	Inquiry
Beijing Solarbio Science & Tecnology Co., Ltd.	010-50973130 4009686088	China	29786	68	Inquiry
Zhongke Huayao (Jiangsu) Biotechnology Co., Ltd	18014456767 18014456767	China	1349	58	Inquiry

Supplier	Advantage
Shenzhen Nexconn Pharmatechs Ltd	58
BOC Sciences	58
career henan chemical co	58
Zhejiang J&C Biological Technology Co.,Limited	58
Alfa Chemistry	58
TargetMol Chemicals Inc.	58
Hebei Miaoyin Technology Co.,Ltd	58
Nanjing TGpeptide	58
Beijing Solarbio Science & Tecnology Co., Ltd.	68
Zhongke Huayao (Jiangsu) Biotechnology Co., Ltd	58

H-MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU-OH Spectrum

H-MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU-OH(249537-73-3)MS

249537-73-3(H-MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU-OH)Related Search:

H-GLU-GLU-OH H-MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU-OH Nfat Inhibitor

MAGPHPVIVITGPHEE MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU H-MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU-OH NFAT INHIBITOR VIVIT NFAT Inhibitor,VIVIT peptide,MAGPHPVIVITGPHEE?, >98% NFAT INHIBITOR?, >98% NFAT Inhibitor (VIVIT peptide) L-Glutamic acid, L-methionyl-L-alanylglycyl-L-prolyl-L-histidyl-L-prolyl-L-valyl-L-isoleucyl-L-valyl-L-isoleucyl-L-threonylglycyl-L-prolyl-L-histidyl-L-α-glutamyl- NFAT Inhibitor >96% (HPLC), solid L-Methionyl-L-Alanylglycyl-L-Prolyl-L-Histidyl-L-Prolyl-L-Valyl-L-Isoleucyl-L-Valyl-L-Isoleucyl-L-Threonylglycyl-L-Prolyl-L-Histidyl-L-alpha-Glutamyl-L-Glutamic Acid NFAT Inhibitor-1 249537-73-3 C75H118N20O22S BioChemical Cell Signaling and Neuroscience Cell Biology Gene Regulation and Expression Gene Regulation Gene Regulation Cell Signaling and Neuroscience Gene Regulation and Expression