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ChemicalBook > Product Catalog >Pharmaceutical intermediates >Heterocyclic compound >Pyrimidines >Thio pyrimidine >2-(Methylthio)-5-pyrimidinecarboxylic acid ethyl ester

2-(Methylthio)-5-pyrimidinecarboxylic acid ethyl ester

2-(Methylthio)-5-pyrimidinecarboxylic acid ethyl ester Structure
CAS No.
73781-88-1
Chemical Name:
2-(Methylthio)-5-pyrimidinecarboxylic acid ethyl ester
Synonyms
ETHYL-2-THIOM;2-(Methylthio)-5-pyr;Lemborexant Impurity 15;ETHYL-2-THIOMETHYL-PYRIMIDINE-5-CAROXYLATE;ETHYL-2-THIOMETHYL-PYRIMIDINE-5-CARBOXYLATE;ETHYL 2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLATE;Ethyl 2-(methylthio)-5-pyrimidinecarboxylate;Ethyl (2-methylthio)-5-pyrimidine canboxylate;2-Methylsulfanyl-pyriMidine-5-carboxylic acid;2-METHYLTHIO-5-PYRIMIDINECARBOXYLIC ACID ETHYL ESTER
CBNumber:
CB6208354
Molecular Formula:
C8H10N2O2S
Molecular Weight:
198.24
MOL File:
73781-88-1.mol
Modify Date:
2023/12/6 15:20:02
Request For Quotation

2-(Methylthio)-5-pyrimidinecarboxylic acid ethyl ester Properties

Melting point 38-40 °C
Boiling point 313.5±15.0 °C(Predicted)
Density 1.24±0.1 g/cm3(Predicted)
pka -0.77±0.22(Predicted)
InChI InChI=1S/C8H10N2O2S/c1-3-12-7(11)6-4-9-8(13-2)10-5-6/h4-5H,3H2,1-2H3
InChIKey LVNRRUKCFUSBDL-UHFFFAOYSA-N
SMILES C1(SC)=NC=C(C(OCC)=O)C=N1
CAS DataBase Reference 73781-88-1(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS05,GHS07
Signal word  Danger
Hazard statements  H302-H312-H318-H332
Precautionary statements  P280-P305+P351+P338
Risk Statements  36/37/38
Safety Statements  26-36/37/39
HS Code  29335990

2-(Methylthio)-5-pyrimidinecarboxylic acid ethyl ester Chemical Properties,Uses,Production

Synthesis

To the stirred solution of ethyl 4-chloro-2-(methylsulfanyl)pyrimidine-5-carboxylate (4.0 g, 17.2 mmol) in ethanol in a hydrogenation vessel, Na2CO3 (1.4 g, 16.7 mmol) and 10% Pd-C (2.0 g) were added and degassed for about 10 min. The reaction mixture was kept in a hydrogenation parr shaker (60 psi) for 48 h. The reaction mixture was filtered through the elite, washed with ethanol, and concentrated under reduced pressure to get 2-(Methylthio)-5-pyrimidinecarboxylic acid ethyl ester as a pale yellow liquid (3.3 g. yield: 98.2 g, %).
2-(Methylthio)-5-pyrimidinecarboxylic acid ethyl ester

2-(Methylthio)-5-pyrimidinecarboxylic acid ethyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

2-HYDROXYPYRIMIDINE-5-CARBOXYLIC ACID

2-(Methylthio)-5-pyrimidinecarboxylic acid ethyl ester Suppliers

Global( 143)Suppliers
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A.J Chemicals 91-9810153283 New Delhi, India 6100 58 Inquiry
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CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6257 58 Inquiry
Nanjing Fred Technology Co., Ltd +86-25-84696168 +86-15380713688 China 2428 58 Inquiry
Capot Chemical Co.,Ltd. +86-（0）57185586718 +86-13336195806 China 29730 60 Inquiry
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SIMAGCHEM CORP +86-13806087780 China 17365 58 Inquiry
Dideu Industries Group Limited +86-29-89586680 +86-15129568250 China 22854 58 Inquiry
Baoji Guokang Bio-Technology Co., Ltd. 0917-3909592 13892490616 China 9304 58 Inquiry
Supplier Advantage
A.J Chemicals 58
CHEMSWORTH 30
CLEARSYNTH LABS LTD. 58
Nanjing Fred Technology Co., Ltd 58
Capot Chemical Co.,Ltd. 60
career henan chemical co 58
CONIER CHEM AND PHARMA LIMITED 58
SIMAGCHEM CORP 58
Dideu Industries Group Limited 58
Baoji Guokang Bio-Technology Co., Ltd. 58

73781-88-1(2-(Methylthio)-5-pyrimidinecarboxylic acid ethyl ester)Related Search:

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ETHYL-2-THIOMETHYL-PYRIMIDINE-5-CARBOXYLATE Ethyl 2-(methylthio)-5-pyrimidinecarboxylate ETHYL 2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLATE 2-METHYLTHIO-5-PYRIMIDINECARBOXYLIC ACID ETHYL ESTER ETHYL-2-THIOMETHYL-PYRIMIDINE-5-CAROXYLATE 2-(Methylthio)-5-pyr Ethyl 2-(methylsulphanyl)pyrimidine-5-carboxylate, Ethyl 2-(methylmercapto)pyrimidine-5-carboxylate 2-Methylsulfanyl-pyriMidine-5-carboxylic acid Ethyl (2-methylthio)-5-pyrimidine canboxylate 2-(Methylthio)-5-pyrimidinecarboxylic acid ethyl ester ISO 9001：2015 REACH 5-Pyrimidinecarboxylic acid, 2-(methylthio)-, ethyl ester 2-methylthio-5-pyrimidinecarboxulic acid ethyl ester ETHYL-2-THIOM Lemborexant Impurity 15 73781-88-1 C8H10N2O2S Heterocycles Heterocyclic Compound