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1,4-DIHYDRO-2-(METHYLTHIO)-4-OXO-5-PYRIMIDINE-CARBOXYLATE ACID ETHYL ESTER

1,4-DIHYDRO-2-(METHYLTHIO)-4-OXO-5-PYRIMIDINE-CARBOXYLATE ACID ETHYL ESTER Structure
CAS No.
53554-29-3
Chemical Name:
1,4-DIHYDRO-2-(METHYLTHIO)-4-OXO-5-PYRIMIDINE-CARBOXYLATE ACID ETHYL ESTER
Synonyms
BUTTPARK;AvafilImpurity32;BUTTPARK 21\07-73;RSYY(Apremilast)-4;Avanafil Impurity 86;1,4-Dihydro-2-(methylthio)-4-oxo-5;1,4-DHYDRO-2-(METHYLTHIO)-4-OXO-5-PYRIMIDINE;1,4-Dihydro-2-(methylthio)-4-oxo-5-pyrimidine-;4-hydroxy-2-methylthiopyrimidine-5-ethyl formate;Ethyl 4-hydroxy-2-methylthio-5-pyrimidinecarboxylate
CBNumber:
CB8337586
Molecular Formula:
C8H10N2O3S
Molecular Weight:
214.24
MOL File:
53554-29-3.mol
MSDS File:
SDS
Modify Date:
2023/4/27 16:27:43
Request For Quotation

1,4-DIHYDRO-2-(METHYLTHIO)-4-OXO-5-PYRIMIDINE-CARBOXYLATE ACID ETHYL ESTER Properties

Melting point 136-144°C
Density 1.37±0.1 g/cm3(Predicted)
storage temp. 2-8°C
pka 6.48±0.50(Predicted)
CAS DataBase Reference 53554-29-3(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P305+P351+P338
Hazard Codes  Xi
HazardClass  IRRITANT
HS Code  2933599590

1,4-DIHYDRO-2-(METHYLTHIO)-4-OXO-5-PYRIMIDINE-CARBOXYLATE ACID ETHYL ESTER Chemical Properties,Uses,Production

Uses

1,4-Dihydro-2-methylmercapto-4-oxo-5-pyrimidinecarboxylic acid ethyl ester can be used as several synthetic intermediates and pharmaceutical intermediates, mainly used in laboratory research and development process and pharmaceutical and chemical production process.

Synthesis

Methylthiourea sulfate (75.2g, 0.4mol) was added to 16% NaOH (250mL, 1.18mol) solution and stirred for 30min, then diethyl ethoxymethylenemalonate (103.4g, 0.48 mol) was dissolved in 160 mL of ethanol and slowly dropped into the reaction solution. After the dropwise addition was completed, the reaction was carried out at room temperature for 10 h.When a large amount of white solid was precipitated, carry out suction filtration, wash with water, and vacuum dry to obtain a white solid (84.7g, 99.7%); ESE-MS (m/z): 249[M+H]+, 236.9[M+Na]+ , after verification, the product is 1,4-dihydro-2-methylmercapto-4-oxo-5-pyrimidinecarboxylic acid ethyl ester.

1,4-DIHYDRO-2-(METHYLTHIO)-4-OXO-5-PYRIMIDINE-CARBOXYLATE ACID ETHYL ESTER Preparation Products And Raw materials

Raw materials

Ethanol Acetic anhydride Potassium hydroxide Diethyl ethoxymethylenemalonate Triethyl orthoformate
Sodium Phosphorus oxychloride Benzene 2-Methyl-2-thiopseudourea sulfate Diethyl malonate
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Preparation Products

5-PyriMidinecarboxylic acid, 4-[[(3-chloro-4-Methoxyphenyl)Methyl]aMino]-2-[(2S)-2-(hydroxyMethyl)- 1-pyrrolidinyl]- 4-Hydroxy-2-(methylthio)pyrimidine-5-carboxylic acid

1,4-DIHYDRO-2-(METHYLTHIO)-4-OXO-5-PYRIMIDINE-CARBOXYLATE ACID ETHYL ESTER Suppliers

Global( 199)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Sapala Organics Private Limited +91-4027170174 +91-9963110948 Telangana, India 89 58 Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
Gagri Global IT Services Pvt. Ltd. +91-40-27170174, Telangana, India 1321 58 Inquiry
SRC Laboratories Pvt Ltd +91 (40) 2307-7999 New Delhi, India 243 50 Inquiry
Dr. Jagath Reddy's Heterocyclics 91-40-23773841 91-40-65572151 New Delhi, India 3886 42 Inquiry
Chongqing Ensky Pharmaceutical Co.,Ltd. +86-23-86815286 +86-13983794297 China 91 58 Inquiry
Capot Chemical Co.,Ltd. 571-85586718 +8613336195806 China 29798 60 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32835 60 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29899 58 Inquiry
Accela ChemBio Inc. +1-858-6993322 United States 19751 58 Inquiry
Supplier Advantage
Sapala Organics Private Limited 58
A.J Chemicals 58
Gagri Global IT Services Pvt. Ltd. 58
SRC Laboratories Pvt Ltd 50
Dr. Jagath Reddy's Heterocyclics 42
Chongqing Ensky Pharmaceutical Co.,Ltd. 58
Capot Chemical Co.,Ltd. 60
ATK CHEMICAL COMPANY LIMITED 60
career henan chemical co 58
Accela ChemBio Inc. 58

53554-29-3(1,4-DIHYDRO-2-(METHYLTHIO)-4-OXO-5-PYRIMIDINE-CARBOXYLATE ACID ETHYL ESTER)Related Search:

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1,4-Dihydro-2-(methylthio)-4-oxo-5-pyrimidine-1,4-Dihydro-2-(methylthio)-4-oxo-5-pyrimidine- 5-PyriMidinecarboxylicacid, 1,6-dihydro-2-(Methylthio)-6-oxo-, ethyl ester Ethyl 2-Methylsulfanyl-6-oxo-1h-pyriMidine-5-carboxylate Ethyl 2-(Methylthio)-6-oxo-1,6-dihydropyriMidine-5-carboxylate 1,4-dihydro-2-Methyl-4-oxo-5-Mercapto-pyriMidine-carboxylic acid ethyl ester Ethyl 2-(methylsulfanyl)-4-oxo-1,4-dihydropyrimidine-5-carboxylate 1,4-Dihydro-2-(methylthio)-4-oxo-5-pyrimidine- 1,4-DIHYDRO-2-(METHYLTHIO)-4-OXO-5-PYRIMIDINECARBOXYLIC ACID ETHYL ESTER >98% 5-PYRIMIDINECARBOXYLICACID,1,4-DIHYDRO-2-(METHYLTHIO)-4-OXO-,ETHYLESTER ethyl 4-hydroxy-2-(methylthio)pyrimidine-5-carboxylate Ethyl 1,4-dihydro-2-(methylthio)-4-oxopyrimidine-5-carboxylate Ethyl 4-hydroxy-2-methylthio-5-pyrimidinecarboxylate Ethyl 1,4-dihydro-2-(methylsulphanyl)-4-oxopyrimidine-5-carboxylate, 1,4-Dihydro-5-(ethoxycarbonyl)-2-(methylthio)-4-oxopyrimidine Ethyl 1,4-dihydro-2-(Methylthio)-4-oxo-5-pyriMidinecarboxylate 4-Hydroxy-2-Methylsulfanyl-pyriMidine-5-carboxylic acid ethyl ester BUTTPARK 1,4-DIHYDRO-2-(METHYLTHIO)-4-OXO-5-PYRIMIDINE-CARBOXYLATE ACID ETHYL ESTER BUTTPARK 21\07-73 Methyl 4-hydroxy-2-(methylthio)pyrimidine-5-carboxylate 4-hydroxy-2-methylthiopyrimidine-5-ethyl formate Avanafil Impurity 86 Ethyl 2-(methylsulfanyl)-4-oxo-1,4-dihydropyrimidine-5-carbo... 1,4-Dihydro-2-(methylthio)-4-oxo-5 Ethyl 2-thiomethyl-4-hydroxypyrimidine-5-carboxylate AvafilImpurity32 1,4-DHYDRO-2-(METHYLTHIO)-4-OXO-5-PYRIMIDINE RSYY(Apremilast)-4 Ethyl 1,6-dihydro-2-(methylthio)-6-oxo-5-pyrimidinecarboxylate 53554-29-3 pyrimidine