ChemicalBook > Product Catalog >Chemical Reagents >Organic reagents >Esters >Ethyl compound >Diethyl ethoxymethylenemalonate
Diethyl ethoxymethylenemalonate
- CAS No.
- 87-13-8
- Chemical Name:
- Diethyl ethoxymethylenemalonate
- Synonyms
- EMME;Diethyl 2-(ethoxymethylene)malonate;Diethyl 2-(ethoxymethylene)propanedioate;DEEMM;ETHOXYMETHYLENEMALONIC ACID DIETHYL ESTER;onate;2-Ethoxymethylene-malonic acid diethyl ester;tl1483;enemaL;NSC 9068
- CBNumber:
- CB3163908
- Molecular Formula:
- C10H16O5
- Molecular Weight:
- 216.23
- MOL File:
- 87-13-8.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/5/11 20:10:50
| Melting point | -33°C |
|---|---|
| Boiling point | 279-283 °C(lit.) |
| Density | 1.080 g/mL at 20 °C(lit.) |
| vapor pressure | <0.1 hPa |
| refractive index |
n |
| Flash point | 311 °F |
| storage temp. | Store below +30°C. |
| solubility | Chloroform (Slightly), Ethyl Acetate (Slightly) |
| form | Liquid |
| color | Clear colorless to light yellow |
| Water Solubility | insoluble |
| BRN | 880058 |
| InChIKey | LTMHNWPUDSTBKD-UHFFFAOYSA-N |
| LogP | 1.5-2.1 at pH7 |
| CAS DataBase Reference | 87-13-8(CAS DataBase Reference) |
| NIST Chemistry Reference | Propanedioic acid, (ethoxymethylene)-, diethyl ester(87-13-8) |
| EPA Substance Registry System | Propanedioic acid, (ethoxymethylene)-, diethyl ester (87-13-8) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H317-H319-H410 | |||||||||
| Precautionary statements | P261-P273-P280-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-36/37/38-42/43 | |||||||||
| Safety Statements | 26-36/37/39-27-24/25 | |||||||||
| WGK Germany | 1 | |||||||||
| RTECS | OO1100000 | |||||||||
| Autoignition Temperature | 215 °C | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29189090 | |||||||||
| Toxicity | LD50 orally in Rabbit: 925 mg/kg LD50 dermal Rat > 2000 mg/kg | |||||||||
| NFPA 704 |
|
Diethyl ethoxymethylenemalonate price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | D94208 | Diethyl ethoxymethylenemalonate 99% | 87-13-8 | 100G | ₹1910 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | D94208 | Diethyl ethoxymethylenemalonate 99% | 87-13-8 | 500G | ₹5098.58 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 05689 | Diethyl ethoxymethylenemalonate for LC-MS derivatization, LiChropur?, ≥97.0% (GC) | 87-13-8 | 1ML | ₹3442.35 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 05689 | Diethyl ethoxymethylenemalonate for LC-MS derivatization, LiChropur?, ≥97.0% (GC) | 87-13-8 | 10ML | ₹9720.85 | 2022-06-14 | Buy |
| TCI Chemicals (India) | E0255 | Diethyl Ethoxymethylenemalonate min. 97.0 % | 87-13-8 | 25ML | ₹1500 | 2022-05-26 | Buy |
Diethyl ethoxymethylenemalonate Chemical Properties,Uses,Production
Chemical Properties
CLEAR COLOURLESS TO LIGHT YELLOW LIQUID
Uses
Diethyl ethoxymethylenemalonate is used for synthesis of pyrido[3,2-e]pyrimido[1,2-c]pyrimidines. Initially, it was used to monitor lysine decarboxylase activity. It is useful in the determination of amino acids by precolumn derivatization by using reversed-phase high-performance liquid chromatography (HPLC). It plays an important role in the Gould-Jacobs reaction to prepare quinolines. For example, anile reacts with this reagent to give 4-hydroxyquinoline. It acts as an intermediate in the production of flumequine, which is a fluoroquinolone antibiotic.
Safety Profile
Moderately toxic by ingestion. A skin irritant. A combustible liquid. When heated to decomposition it emits acrid smoke and irritating fumes.
Purification Methods
Likely impurity is diethyl diethoxymethylene malonate which is difficult to separate from diethyl ethoxymethylene malonate by distillation, and it is necessary to follow the course of the distillation by the change in refractive index instead of boiling point. After a low boiling fraction is collected, there is obtained an intermediate fraction (n 20 1.414—1.458), the size of which depends on the amount of the diethoxymethylene compound. This fraction is fractionated through a 5inch Vigreux column (p 11) at low pressure avoiding interruption in heating. Fraction b 108-110o/0.25mm is ca 10o lower than the submitters' fraction (b 97.2o/0.25mm, n D 1.4612—1.4623) [Org Synth Coll Vol III 395 1955, Fuson et al. J Org Chem 11 197 1946, Duff & Kendal J Chem Soc 893 1948]. [Beilstein 3 IV 1192.]
Diethyl ethoxymethylenemalonate Preparation Products And Raw materials
Raw materials
Preparation Products
Nalidixic acid
Fleroxacin
7-(TRIFLUOROMETHYL)-4-QUINOLINOL
7-BROMO-3,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXYLIC ACID
Norfloxacin
Ethyl 4-chloro-2-methylthio-5-pyrimidinecarboxylate
Alachlor
ETHYL 4-CHLORO-3-METHYLTHIENO[2,3-B]PYRIDINE-5-CARBOXYLATE
Lomefloxacin
5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one
6-CHLORO-[1,2,4]TRIAZOLO[4,3-B]PYRIDAZINE
3,4-DIHYDRO-8-HYDROXY-4-OXOQUINOLINE-3-CARBOXYLIC ACID
Levofloxacin
4-HYDROXY-7-TRIFLUOROMETHYL-3-QUINOLINECARBOXYLIC ACID
Ethyl 4-chloro-2-(trifluoromethyl)pyrimidine-5-carboxylate
Ethyl 4-hydroxy-2-phenylpyrimidine-5-carboxylate
Orotic acid
Ethyl 7-bromo-3,4-dihydro-4-oxoquinoline-3-carboxylate ,97%
4-HYDROXY-8-METHOXYQUINOLINE-3-CARBOXYLIC ACID
Decoquinate
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Global( 495)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| GLR Innovations | +91 9891111994 | New Delhi, India | 4542 | 58 | Inquiry |
| AMINO ORGANICS | +919866989891 | Hyderabad, India | 275 | 58 | Inquiry |
| MOLECRAFT LIFE SCIENCES PVT LTD | +91 9581188881 | Telangana, India | 189 | 58 | Inquiry |
| JSK Chemicals | +919879767970 | Gujarat, India | 3756 | 58 | Inquiry |
| DHANVI EXIM SERVICES | +91-8790148237 +91-8790148237 | Hyderabad, India | 162 | 58 | Inquiry |
| Otto Chemie Pvt Ltd | +91-2222070099 +91-2266382599 | Maharashtra, India | 429 | 58 | Inquiry |
| SRIKAR Labs | +91-9490599901 +91-9177846399 | Telangana, India | 60 | 58 | Inquiry |
| ALS INDIA LIFE SCIENCES | +91-8977036379 +91-8977036379 | Hyderabad, India | 1879 | 58 | Inquiry |
| Saradhi Organics | 91-7660890360 | Hyderabad, India | 184 | 58 | Inquiry |
| Unitrade Agencies | 08048372548Ext 632 | Mumbai, India | 197 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| GLR Innovations | 58 |
| AMINO ORGANICS | 58 |
| MOLECRAFT LIFE SCIENCES PVT LTD | 58 |
| JSK Chemicals | 58 |
| DHANVI EXIM SERVICES | 58 |
| Otto Chemie Pvt Ltd | 58 |
| SRIKAR Labs | 58 |
| ALS INDIA LIFE SCIENCES | 58 |
| Saradhi Organics | 58 |
| Unitrade Agencies | 58 |
Related articles
- What is Diethyl ethoxymethylenemalonate?
- Diethyl ethoxymethylenemalonate is an intermediate in the production of Flumequine. Moderately toxic by ingestion. A skin irri....
- May 27，2021
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DIETHYL ETHOXYMETHYLENEMALONATE FOR SYNT
(ethoxymethylene)-malonicacidiethylester
(ethoxymethylene)-propanedioicacidiethylester
diethylemme
ethoxymethylenemalonicacid,ethylester
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tl1483
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Diethyl ethoxyMethyleneMalonate 99%
Ethoxy Methylene
Ethoxymethylene Malonate Ester
Diethylethoxmethylenemalonate
Diethyl ethoxymethylenemalonate, 98+%
Ethyl α-carbethoxy-β-ethoxy acrylate
Diethyl ethoxymethylenemalonate, 99+%
ETHOXYMETHYLENE MALONIC ESTER(EMME)
ETHOXYMETHYLENEMALONICACIDDIETHYLESTER(E.M.M.E)
Diethylethoxymethylenmalonat
Ethoxy Diethyl Methylene Malonate
2-Ethoxy-1,1-bis(ethoxycarbonyl)ethene
Diethyl 2-(ethoxymethylidene)propanedioate
1,1-Di(ethoxycarbonyl)-2-ethoxyethene
1,1-Dicarboethoxy-2-ethoxyethylene
Diethyl ethoxymethyl
Diethyl Ethoxymethylidenemalonate
Ethoxy Methylene Methyl Ester (EMME)
NALIDIXIC ACID IMPURITY C
Diethyl ethoxymethylenemalonate CAS NO.87-13-8
enemaL
3-chloro-4-fluorotrifluoromethylene
Nalidixic acid impurity C CRS
DiethylEthoxymethylenemalonate>
Nalidixic Acid EP Impurity C
Ethoxy methyl malonate, diethyl ester
ETHOXY METHYLENE MALONIC DIETHYL ESTER (EMME)//87-13-8
Nalidixic acid impurity C (Y0001792)
DIETHYL ETHOXYMETHYLENEMALONATE For Synthesis
EMME
ETHOXYMETHYLENEMALONIC ACID DIETHYL ESTER
Diethyl 2-(ethoxymethylene)malonate