Orotic acid
- CAS No.
- 65-86-1
- Chemical Name:
- Orotic acid
- Synonyms
- orotic acid anhydrous;2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDINE-4-CARBOXYLIC ACID;2,6-DIHYDROXYPYRIMIDINE-4-CARBOXYLIC ACID;orotic;URACIL-6-CARBOXYLIC ACID;OROTIC ACID FREE ACID ANHYDROUS;Orodin;Oropur;Orotyl;Orotonin
- CBNumber:
- CB5691265
- Molecular Formula:
- C5H4N2O4
- Molecular Weight:
- 156.1
- MOL File:
- 65-86-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/6/12 17:09:27
| Melting point | ≥300 °C |
|---|---|
| Boiling point | 280.29°C (rough estimate) |
| Density | 1.6814 (rough estimate) |
| refractive index | 1.4800 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO : 32 mg/mL (205.00 mM; Need ultrasonic and warming) |
| form | Crystalline Powder |
| pka | pK1:1.8(+1);pK2:9.55(0) (25°C) |
| color | White |
| Water Solubility | Slightly soluble |
| Merck | 13,6942 |
| BRN | 383901 |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| InChIKey | PXQPEWDEAKTCGB-UHFFFAOYSA-N |
| LogP | -0.830 |
| CAS DataBase Reference | 65-86-1(CAS DataBase Reference) |
| NIST Chemistry Reference | Orotic acid(65-86-1) |
| EPA Substance Registry System | Orotic acid (65-86-1) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P301+P312+P330-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 26-36/37/39-22-37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | RM3180000 | |||||||||
| F | 10-21 | |||||||||
| Hazard Note | Harmful | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29335990 | |||||||||
| Toxicity | pic-esc 1 g/L ZAPOAK12,583,72 | |||||||||
| NFPA 704 |
|
Orotic acid price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | O2750 | Orotic acid ≥98% (titration), anhydrous | 65-86-1 | 10G | ₹3052.65 | 2022-06-14 | Buy |
| ALFA India | ALF-B25349-36 | Orotic acid, anhydrous, 97% | 65-86-1 | 500g | ₹27697 | 2022-05-26 | Buy |
| ALFA India | ALF-B25349-22 | Orotic acid, anhydrous, 97% | 65-86-1 | 100g | ₹7197 | 2022-05-26 | Buy |
Orotic acid Chemical Properties,Uses,Production
Chemical Properties
white crystalline powder
Uses
Orotic acid is an intermediate in de novo pyrimidine biosynthesis that may be used to study the specificity and kinetics of orotate phosphoribosyltransferase (OPRT) which catalyzes the reversible phosphoribosyl transfer from 5?-phospho-α-d-ribose 1?-diphosphate (PRPP) to orotic acid (OA), forming pyrophosphate and orotidine 5?-monophosphate (OMP). It is used as a starting material for the potential commercial bioproduction of uridine 5?-monophosphate (UMP) by microbes such as Corynebacterium ammoniagenes (ATCC 6872) or Saccharomyces cerevisiae. It may be used to study the AMPK/SREBP-1 dependent cell signaling pathway and transcription regulation mechanisms that induce hepatic lipogenesis.
Definition
ChEBI: A pyrimidinemonocarboxylic acid that is uracil bearing a carboxy substituent at position C-6.
General Description
White crystals or crystalline powder.
Air & Water Reactions
Slightly soluble in water.
Fire Hazard
Flash point data for Orotic acid are not available; however, Orotic acid is probably combustible.
Safety Profile
Moderately toxic by ingestion, intraperitoneal, and intravenous routes. Mutation data reported. Whenheated to decomposition it emits toxic fumes of NOx.
Orotic acid Preparation Products And Raw materials
Raw materials
6-Methyluracil
Sodium dichromate dihydrate
1,3-Bisbenzyl-2-oxoimidazolidine-4,5-dicarboxylic acid
Diethyl ethoxymethylenemalonate
Diethyl oxalate
Urea
Acetic acid
Selenium dioxide
Sulfuric acid
6-(diethoxymethyl)-2-sulfanylidene-1H-pyrimidin-4-one
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Global( 473)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| ANJI BIOSCIENCES | +91-9000100077 +91-9000100077 | Hyderabad, India | 430 | 58 | Inquiry |
| CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6707 | 30 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6913 | 58 | Inquiry |
| Solitude Global Impex | 08048371882Ext 788 | Delhi, India | 17 | 58 | Inquiry |
| Santo Righello Private Limited | 08068970644Ext 147 | Hyderabad, India | 29 | 58 | Inquiry |
| Chaturya Biotech (Tanuj Life Sciences) | 91-7702707258 | Hyderabad, India | 399 | 58 | Inquiry |
| Saradhi Organics | 91-7660890360 | Hyderabad, India | 184 | 58 | Inquiry |
| Rumit International (part of Rumit Group of Companies) | 91-22-61418100 | Maharashtra, India | 75 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| ANJI BIOSCIENCES | 58 |
| CHEMSWORTH | 30 |
| CLEARSYNTH LABS LTD. | 58 |
| A.J Chemicals | 58 |
| Alfa Aesar | 58 |
| Solitude Global Impex | 58 |
| Santo Righello Private Limited | 58 |
| Chaturya Biotech (Tanuj Life Sciences) | 58 |
| Saradhi Organics | 58 |
| Rumit International (part of Rumit Group of Companies) | 58 |
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6-CARBOXYURACIL
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4-CARBOXYURACIL
2 6-DIOXO-1 2 3 6-TETRAHYDRO-4-PYRIMIDINECARBOXYLIC ACID
2,6-DIOXY-1,2,3,6-TETRAHYDRO-4-PYRIMIDINECARBOXYLIC ACID
2 4-DIHYDROXYPYRIMIDINE-4-CARBOXYLIC ACID
1,2,3,6-TETRAHYDRO-2,6-DIOXO-4-PYRIMIDINECARBOXYLIC ACID
URACIL-4-CARBOXYLIC ACID
Orotic acid, 98%, anhydrous
Orotic acid (6-Carboxyuracil)
Orotic aci
Orotic acid, 4-Carboxy-2,6-dioxo-1,2,3,6-tetrahydropyrimidine
Orotic acid 0
H-ORO-OH
VITAMIN B13
TIMTEC-BB SBB004017
OROTIC ACID FREE ACID ANHYDROUS PLANT*CE LL CULTURE
OROTIC ACID BIOSYNTH
Orotic acid, 99+%
Orotic Acid-15N2
2,6-dioxo-3H-pyrimidine-4-carboxylic acid
URACIL-4-CARBOXYLICACID(OROTICACID)
1,2,3,6-tetrahydro-2,6-dioxo-4-pyrimidecarboxylic acid
OROTIC ACID[URACIL-6-CARBOXYLIC ACID]
1,2,3,6-tetrahydro-2,6-dioxopyrimidine-4-carboxylic acid
2,6-Dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid~Uracil-4-carboxylic acid