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ChemicalBook > Product Catalog >Pharmaceutical intermediates >Heterocyclic compound >Pyrimidines >Chloropyrimidine >Methyl 2,4-dichloropyrimidine-6-carboxylate

Methyl 2,4-dichloropyrimidine-6-carboxylate

Methyl 2,4-dichloropyrimidine-6-carboxylate Structure
CAS No.
6299-85-0
Chemical Name:
Methyl 2,4-dichloropyrimidine-6-carboxylate
Synonyms
Methyl 2,6-dichloropyrimidine-4-carboxylate;2,6-Dichloro-pyrimidine-4-carboxylic acid methyl ester;6-c;NSC45044;2-(3-CHLOROPHENYL)MALONDIALDEHYDE;2,4-dichloropyrimidine-6-carboxylate;2,6-dichloropyrimidine-4-carboxylate;2-(3-chlorophenyl)malondialdehyde,98%;2,4-Dichloro-6-(methoxycarbonyl)pyrimidine;Methyl 2,4-dichloropyrimidine-6-carboxylate
CBNumber:
CB4326700
Molecular Formula:
C6H4Cl2N2O2
Molecular Weight:
207.01
MOL File:
6299-85-0.mol
MSDS File:
SDS
Modify Date:
2023/4/27 16:27:43
Request For Quotation

Methyl 2,4-dichloropyrimidine-6-carboxylate Properties

Melting point 54-56
Boiling point 306 ºC
Density 1.503
Flash point 139 ºC
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
form White to off white to faint cream flakes
pka -5.83±0.30(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
Hazard Codes  Xi
HazardClass  IRRITANT
HS Code  2933599590

Methyl 2,4-dichloropyrimidine-6-carboxylate Chemical Properties,Uses,Production

Synthesis

To a stirred suspension of orotic acid (20.00 g, 128.140 mmol) in POCI3(75 ml) was added DMF (catalytic amount, -0.5 ml) at ambient temperature, and the resulting reaction mixture was refluxed for 3 h. Excess of POC was removed by vacuum distillation after 3h of reflux. The obtained slurry was poured slowly into a 5 per cent mixture of methanol in chloroform (200 ml) at 0°C and stirred for 30 min. The organic layer obtained was washed with a saturated solution of NaHCC>3 (3 x 200 ml). The combined organic phase was dried over Na2S04, filtered and concentrated under reduced pressure, yielding Methyl 2,4-dichloropyrimidine-6-carboxylate (19.00 g, 91 .800 mmol).

Methyl 2,4-dichloropyrimidine-6-carboxylate Preparation Products And Raw materials

Raw materials

Heptane N,N-Dimethylformamide Sodium sulfate Phosphorus oxychloride Orotic acid
Diethyl ether Benzene Methanol Thionyl chloride Activated carbon
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Preparation Products

AZ20 4-Pyrimidinecarboxylic acid, 2-chloro-6-(methylthio)-, methyl ester

Methyl 2,4-dichloropyrimidine-6-carboxylate Suppliers

Global( 203)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
Reax Chemicals 08048372701Ext 416 Hyderabad, India 4223 58 Inquiry
Alfa Aesar 1 800 209 7001 Maharashtra, India 6913 58 Inquiry
Nanjing Yushan Wanfang Biotechnology Co., Ltd. +86-025-84918180 +86-18014482516 China 1001 58 Inquiry
Capot Chemical Co.,Ltd. 571-85586718 +8613336195806 China 29798 60 Inquiry
Hangzhou FandaChem Co.,Ltd. 008657128800458; +8615858145714 China 9337 55 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29897 58 Inquiry
Changzhou Ditong Chemical Co.,Ltd +86-0519-88299272 China 2169 58 Inquiry
Chongqing Chemdad Co., Ltd +86-023-6139-8061 +86-86-13650506873 China 39916 58 Inquiry
Supplier Advantage
A.J Chemicals 58
Reax Chemicals 58
Alfa Aesar 58
Nanjing Yushan Wanfang Biotechnology Co., Ltd. 58
Capot Chemical Co.,Ltd. 60
Hangzhou FandaChem Co.,Ltd. 55
ATK CHEMICAL COMPANY LIMITED 60
career henan chemical co 58
Changzhou Ditong Chemical Co.,Ltd 58
Chongqing Chemdad Co., Ltd 58

Methyl 2,4-dichloropyrimidine-6-carboxylate Spectrum

2-(3-CHLOROPHENYL)MALONDIALDEHYDE(6299-85-0)1HNMR2-(3-CHLOROPHENYL)MALONDIALDEHYDE(6299-85-0)FT-IR

6299-85-0(Methyl 2,4-dichloropyrimidine-6-carboxylate)Related Search:

Sulfadiazine 2,4-Dichloropyrimidine 2-(4-CHLOROPHENYL)MALONDIALDEHYDE 95% 2-(4-CHLOROPHENYL)MALONDIALDEHYDE, 95,2-(2-Chlorophenyl)malondialdehyde 2-(4-CHLOROPHENYL)MALONDIALDEHYDE
PYRIMIDINE-4-CARBOXYLIC ACID METHYL ESTER 2-(3-CHLOROPHENYL)MALONDIALDEHYDE 2-Chloropyrimidine-4-carboxylic acid ETHYL 2,6-DICHLORO-5-NITROPYRIMIDINE-4-CARBOXYLATE 4-PYRIMIDINECARBOXALDEHYDE, 2,6-DICHLORO-
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2,4-Dichloro-6-(methoxycarbonyl)pyrimidine 2,6-dichloropyrimidine-4-carboxylate 2,6-DICHLORO-PYRIMIDINE-4-CARBOXYLIC ACID ETHYL ESTER NSC45044 Methyl 2,4-dichloropyrimidine-6-carboxylate 99% Methyl2,4-dichloropyrimidine-6-carboxylate99% 2-(3-CHLOROPHENYL)MALONDIALDEHYDE 4-Methyl-2-(3,4-dichlorophenyl)thiazole-5-carboxylicacid Methyl 2,4-dichloropyrimidine-6-carboxylate 4-PyriMidinecarboxylicacid, 2,6-dichloro-, Methyl ester 2,4-dichloropyrimidine-6-carboxylate Tert-butyl n-(2-(4-nitrophenyl)ethyl)carbamate 6-c Methyl 2,6-dichloropyrimidine-4-carboxylate 2,6-Dichloro-pyrimidine-4-carboxylic acid methyl ester 2-(3-chlorophenyl)malondialdehyde,98% 6299-85-0 6299-45-0 Heterocycle-Pyrimidine series pharmacetical