Calcium D-Pantothenate
- CAS No.
- 137-08-6
- Chemical Name:
- Calcium D-Pantothenate
- Synonyms
- CALCIUM PANTOTHENATE;VITAMIN B5;D-CALCIUM PANTOTHENATE;CALCIUM D-PANTOTHENATE;Calpan;Pantothenic acid calcium;D-PANTOTHENIC ACID HEMICALCIUM SALT;D-PANTOTHENIC ACID CALCIUM SALT;pancal;Pantholin
- CBNumber:
- CB3695335
- Molecular Formula:
- C9H17NO5.1/2Ca
- Molecular Weight:
- 476.53
- MOL File:
- 137-08-6.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/8/24 19:19:26
| Melting point | 190 °C |
|---|---|
| alpha | 26.5 º (c=5, in water) |
| refractive index | 27 ° (C=5, H2O) |
| Flash point | 145 °C |
| storage temp. | 2-8°C |
| solubility | H2O: 50 mg/mL at 25 °C, clear, nearly colorless |
| form | Powder |
| color | White or almost white |
| PH | 6.8-7.2 (25℃, 50mg/mL in H2O) |
| Odor | Odorless |
| optical activity | [α]20/D +27±2°, c = 5% in H2O |
| Water Solubility | Soluble in water. |
| Sensitive | Hygroscopic |
| Merck | 14,7015 |
| BRN | 3769272 |
| Stability | Stable, but may be moisture or air sensitive. Incompatible with strong acids, strong bases. |
| InChIKey | FAPWYRCQGJNNSJ-UBKPKTQASA-L |
| LogP | -0.849 (est) |
| CAS DataBase Reference | 137-08-6(CAS DataBase Reference) |
| EPA Substance Registry System | Calcium pantothenate (137-08-6) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 20/21/22-37/38-41-48 | |||||||||
| Safety Statements | 24/25-45-36/37/39-26-22 | |||||||||
| WGK Germany | 1 | |||||||||
| RTECS | RU4375000 | |||||||||
| F | 3-10 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29362400 | |||||||||
| NFPA 704 |
|
Calcium D-Pantothenate price More Price(22)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | PHR1232 | Calcium-d-pantothenate Pharmaceutical Secondary Standard; Certified Reference Material | 137-08-6 | 500MG | ₹8356.9 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | P5155 | D-Pantothenic acid hemicalcium salt BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture | 137-08-6 | 100G | ₹8573.4 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | C8731 | Calcium pantothenate meets USP testing specifications, monograph mol wt. 476.53 (C18H32CaN2O10) | 137-08-6 | 25G | ₹13325.58 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | P5155 | D-Pantothenic acid hemicalcium salt BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture | 137-08-6 | 500G | ₹29000.18 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | C8731 | Calcium pantothenate meets USP testing specifications, monograph mol wt. 476.53 (C18H32CaN2O10) | 137-08-6 | 100G | ₹42953.6 | 2022-06-14 | Buy |
Calcium D-Pantothenate Chemical Properties,Uses,Production
Chemical Properties
Calcium D-Pantothenate is white crystalline powder
History
Pantothenic acid (PA), also known as vitamin B5, is essential to all forms of life. Its name is derived from the Greek word pantos that means “everywhere”, which is appropriate for this widely, distributed vitamin.
Uses
D-(+)-Pantothenic acid calcium salt is a member of the B complex vitamins; essential vitamin for the biosynthesis of coenzyme A in mammalian cells. Occurs ubiquitously in all animal and plant tissue. The richest common source is liver, but jelly of the queen bee contains 6 times as much as liver. Rice bran and molasses are other good sources.
Definition
Calcium pantothenate, also known as calcium D-pantothenate or calcium pantothenic acid, is a naturally occurring form of pantothenic acid, an essential vitamin found in various foods. Calcium pantothenate is generally recognized as safe (GRAS) in the United States and in Europe. The US FDA requires infant formulas have at least 300 micrograms (mcg) per 100 calories of prepared formula.
Reactions
Pantothenic acid is a constituent of coenzyme A, which participates in numerous enzyme reactions. CoA was discovered as an essential cofactor for the acetylation of sulfanilamide in the liver and of choline in the brain.
Biological Functions
Calcium D-Pantothenate accelerates the wound healing process by increasing the number of migrating cells, their distance and hence their speed. In addition, cell division is increased and the protein synthesis changed. Hence, higher quantities of pantothenate are locally required to enhance wound healing.
General Description
The first suggestion for the existance of vitamin B5 came from Carter et al. in 1930; although it was never characterized or isolated. This vitamin is synthesized by most green plants and microorganisms. Excellent sources of the vitamin are liver, egg yolk, whole grains, and fortified ready-to-eat cereals. However, as the original name implies, many foods contain sufficient pantothenic acid to supply dietary needs.
Chemically, pantothenic acid is considered to be aβ-alanine derivative of the asymmetric pantoic acid and thus shows asymmetry. Only the naturally occurring D(+)- stereoisomer (with R configuration) is biologically active and the L(-)-stereoisomer (with S configuration) is inactive. When its carboxylate functional group is attached through an amide linkage with β-mercaptoethylamine, it is known as pantetheine (also spelled pantotheine). The biologically active form of pantothenic acid, CoA, is formed when the terminal alcoholic function of pantetheine is attached to ADP 3'-phosphate.
Clinical Use
The only therapeutic indication for pantothenic acid is intreatment of a known or suspected deficiency of this vitamin.Because of the ubiquitous nature of pantothenic acid, deficiencystates of this vitamin are only seen experimentally byuse of synthetic diets devoid of the vitamin, by use of thevitamin antagonist, ω-methylpantothenic, or both. In a 1991review, Tahiliani and Beinlich described that the mostcommon symptoms associated with pantothenic acid deficiencywere headache, fatigue, and a sensation of weakness.Sleep disturbances and gastrointestinal disturbances, amongothers, were also noted. The most likely setting for pantothenicacid deficiency is in the setting of alcoholism wherea multiple vitamin deficiency exists confounding the exactrole of the pantothenic acid deficiency as compared to theother vitamins. Because a deficiency of a single B vitamin israre, pantothenic acid is commonly formulated in multivitaminor B-complex preparations.
Safety Profile
Moderately toxic by intraperitoneal, subcutaneous, and intravenous routes. Mildly toxic by ingestion. A vitamin. See also CALCIUM COMPOUNDS. When heated to decomposition it emits toxic fumes of NOx.
Purification Methods
The salt crystallises as needles from MeOH, EtOH or isoPrOH (with 0.5mol of isoPrOH). It is moderately hygroscopic. The S-benzylisothiuronium salt has m 151-152o (149o when crystallised from Me2CO). [Kagan et al. J Am Chem Soc 79 3545 1957, Wilson et al. J Am Chem Soc 76 5177 1954, Stiller & Wiley J Am Chem Soc 63 1239 1941, Beilstein 4 IV 2569.]
Calcium D-Pantothenate Preparation Products And Raw materials
Raw materials
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chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| ADVENT CHEMBIO PRIVATE LIMITED | +91-9821524116 +91-9821524116 | Mumbai, India | 353 | 58 | Inquiry |
| AnalyticsStanza Inc | +91-7032031309 +91-7032031309 | Hyderabad, India | 227 | 58 | Inquiry |
| Medi Pharma Drug House | +919930911911 | Mumbai, India | 143 | 58 | Inquiry |
| Stabicoat Vitamins | +91-9376122600 +91-9825493831 | Gujarat, India | 4 | 58 | Inquiry |
| Rivashaa Agrotech Biopharma Pvt. Ltd. | +91-26463395 +91-7926462688 | Gujarat, India | 1615 | 58 | Inquiry |
| Suvan LifeSciences (formerly Sansh Biotech Pvt Ltd) | +91-1142631798 +91-9899000024 | New Delhi, India | 55 | 58 | Inquiry |
| Supreem Pharmaceuticals Mysore Pvt Ltd | +91-9449813468 +91-9741498883 | Karnataka, India | 13 | 58 | Inquiry |
| Rivashaa Agrotech Biopharma Pvt. Ltd. | 91-79-26462688 | Gujarat, India | 987 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
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