Vitamin K1
- CAS No.
- 84-80-0
- Chemical Name:
- Vitamin K1
- Synonyms
- PHYTONADIONE;PHYTOMENADIONE;PHYLLOQUINONE;Kativn K1;Phytomenadione (Vitamin K1);Kephton;K-Ject;Konakion;aquamephyton;Vitamin K1 5%
- CBNumber:
- CB3482555
- Molecular Formula:
- C31H46O2
- Molecular Weight:
- 450.7
- MOL File:
- 84-80-0.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/6/27 18:15:55
| Melting point | −20 °C(lit.) |
|---|---|
| alpha | D25 -0.28° (dioxane) |
| Boiling point | 140°C 0mm |
| Density | 0.984 g/mL at 25 °C(lit.) |
| refractive index |
n |
| Flash point | >230 °F |
| storage temp. | 2-8°C |
| solubility | Chloroform (Sparingly), Dioxane (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) |
| form | viscous liquid |
| color | Yellow to Dark Yellow |
| Specific Gravity | 0.984 |
| Odor | odorless |
| Water Solubility | Miscible with dehydrated alcohol, acetone, petroleum ether, hexane, dioxane, chloroform, ether, benzene and vegetable oils. Immiscible with water. |
| Sensitive | Light Sensitive |
| Merck | 14,7380 |
| BRN | 2568816 |
| Stability | Light Sensitive |
| InChIKey | MBWXNTAXLNYFJB-LKUDQCMESA-N |
| LogP | 10.305 (est) |
| CAS DataBase Reference | 84-80-0(CAS DataBase Reference) |
| NIST Chemistry Reference | Phytonadione(84-80-0) |
| EPA Substance Registry System | Phylloquinone (84-80-0) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225-H319 | |||||||||
| Precautionary statements | P210-P280-P305+P351+P338-P337+P313-P403+P235 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-37/39-24/25 | |||||||||
| RIDADR | UN1170 - class 3 - PG 2 - Ethanol, solution | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | QJ5800000 | |||||||||
| F | 1-8-10 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29362900 | |||||||||
| NFPA 704 |
|
Vitamin K1 price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | V3501 | Vitamin K1 viscous liquid | 84-80-0 | 1G | ₹11939.98 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | V3501 | Vitamin K1 viscous liquid | 84-80-0 | 5G | ₹21747.43 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | V3501 | Vitamin K1 viscous liquid | 84-80-0 | 10G | ₹37378.73 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | V-030 | Vitamin K1 solution 10?μg/mL in ethanol, certified reference material, Cerilliant? | 84-80-0 | 1ML | ₹7350.18 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 95271 | Vitamin K1 BioXtra, ≥99.0% (sum of isomers, HPLC), mixtur of isomers | 84-80-0 | 250MG | ₹3301.63 | 2022-06-14 | Buy |
Vitamin K1 Chemical Properties,Uses,Production
Description
Vitamin K1 is a fat-soluble, dietary nutrient that is essential for the synthesis of proteins important for blood-clotting, bone metabolism, and cell growth. It is found in the photosynthetic tissues of green, leafy plants, where it acts as an electron acceptor forming part of the electron transport chain of Photosystem I. Vitamin K1 also serves as a precursor to vitamin K2 and is reported to exhibit anticancer activity in various cell lines.
Chemical Properties
Yellow Oil
Uses
vitamin K1
General Description
Vitamin K1, also known as phylloquinone, consists of naphthalenoid and phytyl groups. Phylloquinone is present abundantly in photosynthetic plants and is a major dietary source. It is a fat-soluble vitamin.
Potential Exposure
Phylloquinone is a dietary component essential for normal biosynthesis of several factors required for clotting of blood; as a therapeutic drug used to correct bleeding tendency; and as a food supplement.
Shipping
UN3249 Medicine, solid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials.
Purification Methods
Vitamin K1 is a yellow viscous oil, which can be distilled at high vacuum practically unchanged. It is insoluble in H2O, but soluble in common organic solvents. Store it in the dark under N2 as it is oxygen sensitive. It has 1cm 328 at 248nm. [Fieser et al. J Am Chem Soc 61 2557 1939, Hirschmann et al. J Am Chem Soc 76 4592 1954, Isler & Doebel Helv Chim Acta 27 225 1954, Beilstein 7 IV 2496.]
Incompatibilities
Phylloquinone is photosensitive; decomposes in sunlight and is destroyed by alkali hydroxides and reducing agents such as hydrideds and active metals. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides.
Waste Disposal
It is inappropriate and possibly dangerous to the environment to dispose of expired or waste drugs and pharmaceuticals by flushing them down the toilet or discarding them to the trash. Household quantities of expired or waste pharmaceuticals may be mixed with wet cat litter or coffee grounds, double-bagged in plastic, discard in trash. Larger quantities shall carefully take into consideration applicable DEA, EPA, and FDA regulations. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator.
Vitamin K1 Preparation Products And Raw materials
Raw materials
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chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| SURYA LIFE SCIENCES LIMITED | +91-2646226290 +91-9428511112 | Gujarat, India | 62 | 58 | Inquiry |
| Apothecon Pharmaceuticals Pvt Ltd | +91-2662244212 +91-9099007601 | Gujarat, India | 28 | 58 | Inquiry |
| Merck Ltd | +91-2262109800 +91-2262109000 | Maharashtra, India | 272 | 58 | Inquiry |
| ENALTEC LABS PRIVATE LTD | 91-22-67507000 | New Delhi, India | 27 | 58 | Inquiry |
| EMCURE PHARMACEUTICALS LTD | +91 22 3061 0000 | New Delhi, India | 93 | 58 | Inquiry |
| MSN LABORATORIES PRIVATE LTD | +91 40 30438600 | New Delhi, India | 230 | 58 | Inquiry |
| BIOPHORE INDIA PHARMACEUTICALS PVT LTD | +91-4047474545 | New Delhi, India | 105 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6913 | 58 | Inquiry |
| Sisco Research Laboratories Pvt. Ltd. | +91-22-4268 5800 | Mumbai, India | 4317 | 58 | Inquiry |
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