Hydantoin
- CAS No.
- 461-72-3
- Chemical Name:
- Hydantoin
- Synonyms
- Imidazolidine-2,4-dione;2,4-IMIDAZOLIDINEDIONE;Maine;NSC 922;NSC 9226;HYDANTOIN;GLYCOLYLUREA;Hydantoin>glycollylurea;Hydantoin,99%
- CBNumber:
- CB2352752
- Molecular Formula:
- C3H4N2O2
- Molecular Weight:
- 100.08
- MOL File:
- 461-72-3.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/10/31 18:15:48
| Melting point | 218-220 °C (lit.) |
|---|---|
| Boiling point | 187.47°C (rough estimate) |
| Density | 1.4457 (rough estimate) |
| vapor pressure | 0Pa at 25℃ |
| refractive index | 1.5110 (estimate) |
| storage temp. | Store below +30°C. |
| solubility | SLIGHTLY SOLUBLE |
| form | Fine Powder |
| pka | pKa 9.1 (Uncertain) |
| color | White to light yellow |
| Water Solubility | SLIGHTLY SOLUBLE |
| Merck | 14,4760 |
| BRN | 110598 |
| LogP | -1.69 |
| CAS DataBase Reference | 461-72-3(CAS DataBase Reference) |
| NIST Chemistry Reference | 2,4-Imidazolidinedione(461-72-3) |
| EPA Substance Registry System | 2,4-Imidazolidinedione (461-72-3) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 24/25-36/37/39-27-26 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | MT8210000 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29332100 | |||||||||
| NFPA 704 |
|
Hydantoin price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 8.04511 | Hydantoin for synthesis | 461-72-3 | 100G | ₹2210 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 8.04511 | Hydantoin for synthesis | 461-72-3 | 500G | ₹7300 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 156361 | Hydantoin 98% | 461-72-3 | 100G | ₹2273.25 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 156361 | Hydantoin 98% | 461-72-3 | 500G | ₹8508.45 | 2022-06-14 | Buy |
| ALFA India | ALF-A12486-36 | Hydantoin, 99% | 461-72-3 | 500g | ₹5639 | 2022-05-26 | Buy |
Hydantoin Chemical Properties,Uses,Production
Chemical Properties
White Solid
Uses
The product has been used as a substrate (at 40 °C and pH 9.0) to determine the D-hydantoinase activity in adzuki bean extract.
Uses
Reactant for synthesis of: N-benzyl aplysinopsin analogs as anticancer agents, D-glutamic acid based inhibitors, Antidiabetic chromonyl-2,4-thiazolidinediones, GSK-3β, inhibitors with brain permeability, Thiazolidinedione derivatives as 15-PGDH inhibitors, and Radio-sensitizing agents.
Pharmaceutical Applications
Control of generalized convulsive status epilepticus; prevention and treatment of seizures during neurosurgery; short-term substitute for oral phenytoin.
Mechanism of action
Hydantoins are a class of drugs mainly used to treat seizures (anticonvulsant or antiepileptic drugs). Hydantoins reduce seizures by targeting the sodium channel present throughout the nerves. Activation of sodium channels results in the conduction of electrical impulses and the release of neurotransmitters. It could stabilise neuronal membranes by decreasing sodium and calcium ion influx into the neurons. Also decreases post-tetanic potentiation and repetitive discharge.
Pharmacokinetics
Completely absorbed after IM administration. Protein binding: 95%–99%. Rapidly and completely hydrolyzed to phenytoin after IM or IV administration. Time of complete conversion to phenytoin: 4 hr after IM injection; 2 hr after IV infusion. Half-life: 8–15 min (for conversion to phenytoin).
Hydantoin Preparation Products And Raw materials
Raw materials
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|---|---|---|---|---|---|
| ANJI BIOSCIENCES | +91-9000100077 +91-9000100077 | Hyderabad, India | 429 | 58 | Inquiry |
| DeFINE CHEMICALS | +91-8010769889 +91-9320057099 | Maharashtra, India | 120 | 58 | Inquiry |
| JSK Chemicals | +919879767970 | Gujarat, India | 3753 | 58 | Inquiry |
| SOLFYN INTERNATIONAL LLP | +91-9321772608 +91-9321772608 | Mumbai, India | 452 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6754 | 58 | Inquiry |
| Spectrochem Private Limited | 08048372608Ext 246 | Maharashtra, India | 1055 | 58 | Inquiry |
| CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6700 | 30 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6100 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6257 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6768 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| ANJI BIOSCIENCES | 58 |
| DeFINE CHEMICALS | 58 |
| JSK Chemicals | 58 |
| SOLFYN INTERNATIONAL LLP | 58 |
| Pharma Affiliates | 58 |
| Spectrochem Private Limited | 58 |
| CHEMSWORTH | 30 |
| A.J Chemicals | 58 |
| CLEARSYNTH LABS LTD. | 58 |
| TCI Chemicals (India) Pvt. Ltd. | 58 |
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