Phenytoin sodium
- CAS No.
- 630-93-3
- Chemical Name:
- Phenytoin sodium
- Synonyms
- DILANTIN;epelin;eptoin;epinat;di-len;ditoin;tacosal;alepsin;dihydan;enkefal
- CBNumber:
- CB2304645
- Molecular Formula:
- C15H13N2NaO2
- Molecular Weight:
- 276.27
- MOL File:
- 630-93-3.mol
- Modify Date:
- 2024/11/19 23:02:33
| storage temp. | Inert atmosphere,Room Temperature |
|---|---|
| solubility | aqueous base: soluble |
| form | Crystalline Powder |
| color | White to almost white |
| Merck | 14,7322 |
| BCS Class | 2 |
| Stability | Hygroscopic |
| InChIKey | FJPYVLNWWICYDW-UHFFFAOYSA-M |
| CAS DataBase Reference | 630-93-3(CAS DataBase Reference) |
| EPA Substance Registry System | Diphenylhydantoin sodium (630-93-3) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H317-H361 | |||||||||
| Precautionary statements | P201-P202-P280-P301+P312-P302+P352-P308+P313 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-43-62-63 | |||||||||
| Safety Statements | 22-36/37/39-45 | |||||||||
| RIDADR | UN 2811 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | MU1400000 | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29332100 | |||||||||
| Toxicity | LD50 orally in mice: 490 mg/kg (Fink, Swinyard) | |||||||||
| NFPA 704 |
|
Phenytoin sodium price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | D4505 | 5,5-Diphenylhydantoin sodium salt ≥99% | 630-93-3 | 25G | ₹6040.35 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR1492 | Phenytoin sodium Pharmaceutical Secondary Standard; Certified Reference Material | 630-93-3 | 1G | ₹9103.83 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | D4505 | 5,5-Diphenylhydantoin sodium salt ≥99% | 630-93-3 | 100G | ₹10597.68 | 2022-06-14 | Buy |
| TCI Chemicals (India) | D1331 | Phenytoin Sodium | 630-93-3 | 25G | ₹3400 | 2022-05-26 | Buy |
| TCI Chemicals (India) | D1331 | Phenytoin Sodium | 630-93-3 | 500G | ₹11700 | 2022-05-26 | Buy |
Phenytoin sodium Chemical Properties,Uses,Production
Chemical Properties
White or almost white, crystalline powder, slightly hygroscopic.
Uses
antibacterial
General Description
Phenytoin sodium, 5,5-diphenyl-2,4-imidazolidinedione, 5,5-diphenylhydantoin,diphenyl-hydantoin sodium (Dilantin), has been used fordecades in the control of grand mal types of epilepticseizure. It is structurally analogous to the barbiturates butdoes not possess their extensive sedative properties. Thecompound is available as the sodium salt. Solutions for parenteraladministration contain 40% propylene glycol and10% alcohol to dissolve the sodium salt.
Clinical Use
Phenytoin sodium’s cardiovascular effects were uncoveredduring observation of toxic manifestations of the drugin patients being treated for seizure disorders. Phenytoinsodium was found to cause bradycardia, prolong the PRinterval, and produce T-wave abnormalities on electrocardiograms.It is a class IB antiarrhythmic agent. Today,phenytoin sodium’s greatest clinical use as an antiarrhythmicdrug is in the treatment of digitalis-induced arrhythmias.34 Its action is similar to that of lidocaine. It depressesventricular automaticity produced by digitalis, without adverseintraventricular conduction. Because it also reversesthe prolongation of AV conduction by digitalis, phenytoinsodium is useful in supraventricular tachycardias caused bydigitalis intoxication.
Safety Profile
Confirmed carcinogen. Experimental teratogen. Other experimental reproductive effects. Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Human systemic effects by ingestion: anorexia, respiratory depression, nausea or vomiting, hemorrhage, dermatitis, and endocrine effects. Mutation data reported. An anticonvulsant and cardiac depressant used for the treatment of grand mal and psychomotor seizures. When heated to decomposition it emits very toxic fumes of NOx and Na2O.
Carcinogenicity
Phenytoin and its sodium salt are reasonably anticipated to be human carcinogens based on sufficient evidence from studies in experimental animals.
Solubility in water
1 g dissolves in ca. 66 ml of water. The aqueous solution is turbid unless the pH is adjusted above 11.7, which is the pH of the saturated solution. 1 g dissolves in 10.5 mL of alcohol. Practically insoluble in ether and chloroform.
Phenytoin sodium Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| KARPSCHEM LABORATORIES | +91-7249203006 +91-7249203006 | Maharashtra, India | 786 | 58 | Inquiry |
| JPN Pharma Pvt Ltd | +919833233531 | Maharashtra, India | 33 | 58 | Inquiry |
| Macleods Pharmaceuticals Limited | +91-2266762800 +91-2266762800 | Maharashtra, India | 116 | 58 | Inquiry |
| Unichem Laboratories Ltd | +91-2266888333 +91-2266888333 | Maharashtra, India | 62 | 58 | Inquiry |
| Orchid Pharma Ltd. (Formerly Known as Orchid Chemicals and Pharmaceuticals Ltd.) | +91-4428244254 +91-4428244254 | Tamil Nadu, India | 28 | 58 | Inquiry |
| Harman Finochem Ltd | +91-2226528080 +91-2226528080 | Maharashtra, India | 37 | 58 | Inquiry |
| Rivashaa Agrotech Biopharma Pvt. Ltd. | +91-26463395 +91-7926462688 | Gujarat, India | 1615 | 58 | Inquiry |
| Global Calcium Pvt Ltd | +91-8050750904 +91-8040554500 | Karnataka, India | 132 | 58 | Inquiry |
| Swati Spentose Pvt Ltd | +91-2261505232 +91-2261505232 | Maharashtra, India | 44 | 58 | Inquiry |
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
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