Ketoprofen
- CAS No.
- 22071-15-4
- Chemical Name:
- Ketoprofen
- Synonyms
- 2-(3-BENZOYLPHENYL)PROPANOIC ACID;ORUVAIL;ketoprofene;ORUDIS;Profenid;KETOPROFEN USP;2-(3-BENZOYLPHENYL)PROPIONIC ACID;aneol;Dexal;Topre
- CBNumber:
- CB3299418
- Molecular Formula:
- C16H14O3
- Molecular Weight:
- 254.29
- MOL File:
- 22071-15-4.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/14 20:44:35
| Melting point | 93-96°C |
|---|---|
| Boiling point | 357.5°C (rough estimate) |
| Density | 1.1565 (rough estimate) |
| refractive index | 1.5600 (estimate) |
| storage temp. | 2-8°C |
| solubility | Slightly soluble in chloroform and methanol. |
| pka | pKa 5.94(MeOH/H2O) (Uncertain) |
| form | solid |
| color | White to Off-White |
| Water Solubility | 209mg/L(room temperature) |
| Merck | 14,5305 |
| InChIKey | DKYWVDODHFEZIM-UHFFFAOYSA-N |
| CAS DataBase Reference | 22071-15-4(CAS DataBase Reference) |
| NIST Chemistry Reference | Ketoprofen(22071-15-4) |
| EPA Substance Registry System | Benzeneacetic acid, 3-benzoyl-.alpha.-methyl- (22071-15-4) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301 | |||||||||
| Precautionary statements | P264-P270-P301+P310-P405-P501 | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 25-36/37/38-23/24/25 | |||||||||
| Safety Statements | 26-45-36/37/39 | |||||||||
| RIDADR | 2811 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | UE7570000 | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29183000 | |||||||||
| Toxicity | LD50 orally in rats: 101 mg/kg (Ueno) | |||||||||
| NFPA 704 |
|
Ketoprofen price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | K1751 | Ketoprofen ≥98% (TLC) | 22071-15-4 | 1G | ₹7501.73 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | K2012 | Ketoprofen meets USP testing specifications | 22071-15-4 | 5G | ₹7815.65 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR1375 | Ketoprofen Pharmaceutical Secondary Standard; Certified Reference Material | 22071-15-4 | 500MG | ₹9201.25 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | K1751 | Ketoprofen ≥98% (TLC) | 22071-15-4 | 5G | ₹15642.13 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | K2012 | Ketoprofen meets USP testing specifications | 22071-15-4 | 25G | ₹25763.5 | 2022-06-14 | Buy |
Ketoprofen Chemical Properties,Uses,Production
Chemical Properties
White Crystalline Solid
Uses
Ketoprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with analgesic and antipyretic properties.
Indications
Ketoprofen (Orudis) is indicated for use in rheumatoid and osteoarthritis, for mild to moderate pain, and in dysmenorrhea. The most frequently reported side effects are GI (dyspepsia, nausea, abdominal pain, diarrhea, constipation, and flatulence) and CNS related (headache, excitation). Edema and increased blood urea nitrogen have also been noted in more than 3% of patients. Ketoprofen can cause fluid retention and increases in plasma creatinine, particularly in the elderly and in patients taking diuretics.
Definition
ChEBI: An oxo monocarboxylic acid that consists of propionic acid substituted by a 3-benzoylphenyl group at position 2.
brand name
Actron (Bayer); Orudis (Wyeth); Oruvail (Wyeth), Alrheumat (Bayer, United Kingdom), Alrheumun (Bayer Pharma Deutschland, Germany), Gabrilen (Kreussler, Germany), Orudis (Rh?one-Poulenc Rorer, Canada, Denmark; Wyeth-Ayerst, USA).
General Description
Ketoprofen (Orudis, Rhodis) and suprofen (Profenal) areclosely related to fenoprofen in their structures, properties,and indications. Even though ketoprofen has been approvedfor OTC use (Orudis KT, Actron), its GI side effects aresimilar to indomethacin, and therefore its useshould be closely monitored, especially in patients with GIor renal problems.
Contact allergens
Ketoprofen is an anti-inflammatory drug, used both topically and systemically. It is above all a photoaller- gen, responsible for photoallergic or photo-worsened contact dermatitis, with sun-induced, progressive, severe, and durable reactions. Recurrent photosensitiv- ity is possible for many years. Photosensitivities are expected to thiophene-phenylketone derivatives such as tiaprofenic acid and suprofen, to ketoprofen esters such as piketoprofen, and to benzophenone derivatives (see above) such as fenofibrate and benzophenone-3. Concomitant photosensitivities without clinical rel- evance have been observed to fenticlor, tetrachloro- salicylanilide, triclosan, tribromsalan, and bithionol.
Pharmacokinetics
Ketoprofen is rapidly and nearly completely absorbed on oral administration, reaching peak plasma levels within 0.5 to 2 hours. It is highly plasma protein bound (99%) despite a lower acidity (pKa = 5.9) than some other NSAIDs. Wide variation in plasma half-lives has been reported. It is metabolized by glucuronidation of the carboxylic acid, CYP3A4 and CYP2C9 hydroxylation of the benzoyl ring, and reduction of the keto function.
Clinical Use
Ketoprofen, unlike many NSAIDs, inhibits the synthesis of leukotrienes and leukocyte migration into inflamed joints in addition to inhibiting the biosynthesis of prostaglandins. It stabilizes the lysosomal membrane during inflammation, resulting in decreased tissue destruction. Antibradykinin activity also has been observed. Bradykinin is released during inflammation and can activate peripheral pain receptors. In addition to anti-inflammatory activity, ketoprofen also possesses antipyretic and analgetic properties. Although it is less potent than indomethacin as an anti-inflammatory agent and an analgetic, its ability to produce gastric lesions is about the same.
Safety Profile
Poison by ingestion,subcutaneous, intravenous, rectal, and intraperitoneal routes. Human systemic effects by an unspecified route:headache, nausea or vomiting, and degenerative changesin the brain, changes in kidney tubules. An experimentalteratogen.
Ketoprofen Preparation Products And Raw materials
Raw materials
1of2
chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| SURYA LIFE SCIENCES LIMITED | +91-2646226290 +91-9428511112 | Gujarat, India | 62 | 58 | Inquiry |
| ANWITA APIS | +919000311012 | Hyderabad, India | 198 | 58 | Inquiry |
| J S LABS | +91-7330612784 +91-7330612784 | Tamil Nadu, India | 160 | 58 | Inquiry |
| Vadivarhe Speciality Chemicals Limited | +91-9028832204 +91-9028832204 | Maharashtra, India | 38 | 58 | Inquiry |
| AARTIA KEM SCIENCE | +91-8291072530 +91-8291072530 | Maharashtra, India | 70 | 58 | Inquiry |
| Gonane Pharma | +91-9819380043 +91-9819380043 | NaviMumbai, India | 192 | 58 | Inquiry |
| Synaptics Labs Private Limited | +91-8341963666 +91-8341963666 | Hyderabad, India | 84 | 58 | Inquiry |
| Aalidhra Pharmachem Pvt Ltd | +91-9879180894 +91-9879180894 | Gujarat, India | 38 | 58 | Inquiry |
| Chempifine Chemicals | +91-2225667766 +91-2225667766 | Punjab, India | 144 | 58 | Inquiry |
| Adani Wilmar Limited | +91-7383819375 +91-9099656790 | Gujarat, India | 34 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| SURYA LIFE SCIENCES LIMITED | 58 |
| ANWITA APIS | 58 |
| J S LABS | 58 |
| Vadivarhe Speciality Chemicals Limited | 58 |
| AARTIA KEM SCIENCE | 58 |
| Gonane Pharma | 58 |
| Synaptics Labs Private Limited | 58 |
| Aalidhra Pharmachem Pvt Ltd | 58 |
| Chempifine Chemicals | 58 |
| Adani Wilmar Limited | 58 |
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