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ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Epigenetics >Sirtuin Inhibitors >6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-1-CARBOXAMIDE

6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-1-CARBOXAMIDE

6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-1-CARBOXAMIDE Structure
CAS No.
49843-98-3
Chemical Name:
6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-1-CARBOXAMIDE
Synonyms
Selisistat;EX 527 (SEN0014196);SIRT1 Inhibitor III;CS-1862;Selisista;SEN0014196;(S)-EX-527;EX 527, >=98%;EX 527; EX527;Selisistat - EX 527
CBNumber:
CB6230650
Molecular Formula:
C13H13ClN2O
Molecular Weight:
248.71
MOL File:
49843-98-3.mol
MSDS File:
SDS
Modify Date:
2023/6/30 15:45:59
Request For Quotation

6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-1-CARBOXAMIDE Properties

Melting point 179.0 to 183.0 °C
Boiling point 531.7±38.0 °C(Predicted)
Density 1.388
storage temp. 2-8°C
solubility Soluble in dimethyl sulfoxide, ethanol and dimethyl formamide.
form powder
pka 16.12±0.40(Predicted)
color white to beige
Stability Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07,GHS06
Signal word  Danger
Hazard statements  H301-H319-H302
Precautionary statements  P301+P310-P305+P351+P338-P264-P280i-P301+P312a-P337+P313-P501a
Hazard Codes  Xn
Risk Statements  22-36
Safety Statements  26
RIDADR  UN 2811 6.1 / PGIII
WGK Germany  3
HS Code  2933998090
NFPA 704
0
2 0

6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-1-CARBOXAMIDE price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) E7034 EX-527 ≥98% (HPLC) 49843-98-3 5MG ₹12697.73 2022-06-14 Buy
Sigma-Aldrich(India) E7034 EX-527 ≥98% (HPLC) 49843-98-3 25MG ₹49437.78 2022-06-14 Buy
ALFA India ALF-J64753-MA EX 527 49843-98-3 10mg ₹20643 2022-05-26 Buy
TCI Chemicals (India) C2739 6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 49843-98-3 25MG ₹21500 2022-05-26 Buy
Product number Packaging Price Buy
E7034 5MG ₹12697.73 Buy
E7034 25MG ₹49437.78 Buy
ALF-J64753-MA 10mg ₹20643 Buy
C2739 25MG ₹21500 Buy

6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-1-CARBOXAMIDE Chemical Properties,Uses,Production

Uses

A selective inhibitor of SIRT1 over SIRT2 and SIRT3

General Description

A cell-permeable indole compound that acts as a potent and highly selective inhibitor of SIRT1 (IC50 = 98 nM). It inhibits other sirtuin family deacetylases only at much higher concentrations (IC50 = 19.6 and 48.7 μM for SIRT2 and SIRT3, respectively) and shows no inhibitory effect against class I and II HDACs or NAD glycohydrolase even at concentrations as high as 100 μM. Shown to be orally bioavailable with a serum half-life of 136 minutes in mice in vivo.

Biological Activity

Selective inhibitor of SIRT1 that does not inhibit histone deacetylase (HDAC) or other sirtuin deacetylase family members (IC 50 values are 98, 19600, 48700, > 100000 and > 100000 nM for SIRT1, SIRT2, SIRT3, HDAC and NADase respectively). Enhances p53 acetylation in response to DNA damaging agents.

6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-1-CARBOXAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-1-CARBOXAMIDE Suppliers

Global( 202)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
TCI Chemicals (India) Pvt. Ltd. 1800 425 7889 New Delhi, India 6778 58 Inquiry
Alfa Aesar 1 800 209 7001 Maharashtra, India 6913 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29901 58 Inquiry
Chongqing Chemdad Co., Ltd +86-023-6139-8061 +86-86-13650506873 China 39916 58 Inquiry
Dideu Industries Group Limited +86-29-89586680 +86-15129568250 China 26216 58 Inquiry
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 +1-2135480471 China 10522 58 Inquiry
CD Chemical Group Limited +8615986615575 China 20356 58 Inquiry
Supplier Advantage
A.J Chemicals 58
CLEARSYNTH LABS LTD. 58
TCI Chemicals (India) Pvt. Ltd. 58
Alfa Aesar 58
ATK CHEMICAL COMPANY LIMITED 60
career henan chemical co 58
Chongqing Chemdad Co., Ltd 58
Dideu Industries Group Limited 58
Zhejiang J&C Biological Technology Co.,Limited 58
CD Chemical Group Limited 58

6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-1-CARBOXAMIDE Spectrum

6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-1-CARBOXAMIDE(49843-98-3)1HNMR

49843-98-3(6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-1-CARBOXAMIDE)Related Search:

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6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-1-CARBOXAMIDE 6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-1-CARBOXAMIDE, >95% (S)-6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide SEN0014196 6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide EX-527 Selisistat EX 527, >=98% EX 527 (Selisistat) Selisistat 6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxaMide Selisistat - EX 527 EX 527; EX527 CS-1862 Selisistat (SEN0014196 SELISISTAT;EX 527;EX527;SEN0014196 EX-527; EX-527; EX-527; SELISISTAT. 6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide > (S)-EX-527 1H-Carbazole-1-carboxamide, 6-chloro-2,3,4,9-tetrahydro- 6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-1-CARBOXAMIDE USP/EP/BP Selisistat EX 527 (SEN0014196) SIRT1 Inhibitor III SIRT1 Inhibitor III EX-527 EX527 EX-527/SEN0014196, EX527 Selisista 49843-98-3 C13H13ON2Cl Inhibitors Inhibitor Other enzyme inhibitors and activators