6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-1-CARBOXAMIDE
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6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-1-CARBOXAMIDE 속성
- 녹는점
- 179.0 to 183.0 °C
- 끓는 점
- 531.7±38.0 °C(Predicted)
- 밀도
- 1.388
- 저장 조건
- 2-8°C
- 용해도
- 디메틸 설폭사이드, 에탄올 및 디메틸 포름아미드에 용해됩니다.
- 물리적 상태
- 가루
- 산도 계수 (pKa)
- 16.12±0.40(Predicted)
- 색상
- 흰색에서 베이지색
- 안정성
- 제공된 대로 구매일로부터 2년 동안 안정적입니다. DMSO 또는 에탄올 용액은 -20°C에서 최대 3개월 동안 보관할 수 있습니다.
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-1-CARBOXAMIDE C화학적 특성, 용도, 생산
용도
A selective inhibitor of SIRT1 over SIRT2 and SIRT3일반 설명
A cell-permeable indole compound that acts as a potent and highly selective inhibitor of SIRT1 (IC50 = 98 nM). It inhibits other sirtuin family deacetylases only at much higher concentrations (IC50 = 19.6 and 48.7 μM for SIRT2 and SIRT3, respectively) and shows no inhibitory effect against class I and II HDACs or NAD glycohydrolase even at concentrations as high as 100 μM. Shown to be orally bioavailable with a serum half-life of 136 minutes in mice in vivo.생물학적 활성
Selective inhibitor of SIRT1 that does not inhibit histone deacetylase (HDAC) or other sirtuin deacetylase family members (IC 50 values are 98, 19600, 48700, > 100000 and > 100000 nM for SIRT1, SIRT2, SIRT3, HDAC and NADase respectively). Enhances p53 acetylation in response to DNA damaging agents.6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-1-CARBOXAMIDE 준비 용품 및 원자재
원자재
준비 용품
6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-1-CARBOXAMIDE 공급 업체
글로벌( 202)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32760 | 60 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29894 | 58 |
Biochempartner | 0086-13720134139 |
candy@biochempartner.com | CHINA | 967 | 58 |
Changzhou PBpharmaceutical R&D Co.,Ltd | 0519-83990708 |
info@pbpharm.com | CHINA | 498 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 |
linda@hubeijusheng.com | CHINA | 22968 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 |
sales@chemdad.com | China | 39916 | 58 |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 |
1026@dideu.com | China | 24330 | 58 |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 |
sales@sarms4muscle.com | China | 10522 | 58 |
CD Chemical Group Limited | +8615986615575 |
info@codchem.com | China | 20356 | 58 |
changzhou huayang technology co., ltd | +8615250961469 |
2571773637@qq.com | China | 9827 | 58 |
6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-1-CARBOXAMIDE 관련 검색:
6-Chloro-4-phenylquinazolin-2-carboxaldehyde
6-chloro-7-fluoro-2,3-dihydro-1H-inden-1-one
Everolimus
SIRTINOL
MK-2206 2HCl
Trametinib
SRT1720
PLX4032
6-Chloro-1,2,3,4-tetrahydroisoquinoline
6-chloro-5-methoxy-2,3-dihydro-1H-inden-1-one
6-Chloro-1,3-dimethyl-2,4-(1H,3H)-pyrimidinedione
2(1H)-Pyrimidinone, 4-chloro- (6CI,9CI)
6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-1-CARBOXYLIC ACID
6-CHLORO-4-METHYL-1-INDANONE
6-CHLORO-5-METHYLPYRIDINE-3-CARBALDEHYDE
6-CHLORO-1,2,3,4-TETRAHYDROQUINOLINE
6-CHLORO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE
6-Chloro-7-Bromoindanone