Chinese english Japanese Germany Korea

DICHLORO(2Z)-2-[(4-OXO-4H-1-BENZOPYRAN-3-YL)METHYLENE]HYDRAZINECARBOTHIOAMIDE COPPER COMPLEX

DICHLORO(2Z)-2-[(4-OXO-4H-1-BENZOPYRAN-3-YL)METHYLENE]HYDRAZINECARBOTHIOAMIDE COPPER COMPLEX Structure
CAS No.
902779-59-3
Chemical Name:
DICHLORO(2Z)-2-[(4-OXO-4H-1-BENZOPYRAN-3-YL)METHYLENE]HYDRAZINECARBOTHIOAMIDE COPPER COMPLEX
Synonyms
FPA 124;FPA 124,FPA124;Akt Inhibitor (FPA-124);DICHLORO(2Z)-2-[(4-OXO-4H-1-BENZOPYRAN-3-YL)METHYLENE]HYDRAZINECARBOTHIOAMIDE COPPER COMPLEX
CBNumber:
CB62455619
Molecular Formula:
C11H10Cl2CuN3O2S
Molecular Weight:
382.73
MOL File:
902779-59-3.mol
Modify Date:
2024/7/2 8:55:13
Request For Quotation

DICHLORO(2Z)-2-[(4-OXO-4H-1-BENZOPYRAN-3-YL)METHYLENE]HYDRAZINECARBOTHIOAMIDE COPPER COMPLEX Properties

storage temp. Store at +4°C
solubility Soluble to 10 mM in DMSO and to 10 mM in ethanol
form Powder
color Light green to green

DICHLORO(2Z)-2-[(4-OXO-4H-1-BENZOPYRAN-3-YL)METHYLENE]HYDRAZINECARBOTHIOAMIDE COPPER COMPLEX Chemical Properties,Uses,Production

Description

The kinase Akt (also known as protein kinase B or PKB) modulates cell proliferation, metabolism, and survival, as well as angiogenesis. Akt inhibitor XI is a cell-permeable, copper-containing 3-formylchromone derivative that inhibits Akt in an array of cancer cells (IC50s = 10-34 μM). It also causes NF-κB inactivation in an orthotopic pancreatic tumor model using COLO 357 cells. Molecular modeling indicates that this inhibitor interacts with the pleckstrin homology and kinase domains of Akt. Akt inhibitor XI is commonly used in the range of 1-20 μM to assess the role of Akt in cellular responses.

Biological Activity

Akt/PKB inhibitor (IC 50 = 100 nM) that interacts with the PH and kinase domains. Inhibits cell proliferation in various cancer cell lines in vitro and decreases NF- κ B activity and tumor load in vivo .

DICHLORO(2Z)-2-[(4-OXO-4H-1-BENZOPYRAN-3-YL)METHYLENE]HYDRAZINECARBOTHIOAMIDE COPPER COMPLEX Preparation Products And Raw materials

Raw materials

Preparation Products

DICHLORO(2Z)-2-[(4-OXO-4H-1-BENZOPYRAN-3-YL)METHYLENE]HYDRAZINECARBOTHIOAMIDE COPPER COMPLEX Suppliers

Global( 30)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
Hangzhou MolCore BioPharmatech Co.,Ltd. +86-057181025280; +8617767106207 China 49739 58 Inquiry
TargetMol Chemicals Inc. 4008200310 China 24016 58 Inquiry
Cayman Chemical Company (800) 364-9897 United States 6618 81 Inquiry
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 China 8739 58 Inquiry
Nantong QuanYi Biotechnology Co., Ltd 0513-66337626 18051384581 China 4552 58 Inquiry
RD International Technology Co., Limited 18024082417 China 9282 58 Inquiry
Guangzhou Younan Technology Co., Ltd 020-020-82000279 18988968278 China 4325 58 Inquiry
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037 China 15848 69 Inquiry
J & K SCIENTIFIC LTD. 010-82848833 400-666-7788 China 96815 76 Inquiry
Supplier Advantage
TargetMol Chemicals Inc. 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 58
TargetMol Chemicals Inc. 58
Cayman Chemical Company 81
Shanghai Yifei Biotechnology Co. , Ltd. 58
Nantong QuanYi Biotechnology Co., Ltd 58
RD International Technology Co., Limited 58
Guangzhou Younan Technology Co., Ltd 58
3B Pharmachem (Wuhan) International Co.,Ltd. 69
J & K SCIENTIFIC LTD. 76

902779-59-3(DICHLORO(2Z)-2-[(4-OXO-4H-1-BENZOPYRAN-3-YL)METHYLENE]HYDRAZINECARBOTHIOAMIDE COPPER COMPLEX)Related Search:

Food antioxidant Natural antioxidant ANTIOXIDANT 765 CUPRIC CHLORIDE HYDRATE Cupric chloride
Copper(II) chloride dihydrate DICHLORO(2Z)-2-[(4-OXO-4H-1-BENZOPYRAN-3-YL)METHYLENE]HYDRAZINECARBOTHIOAMIDE COPPER COMPLEX
chevron_left

1of2

chevron_right
DICHLORO(2Z)-2-[(4-OXO-4H-1-BENZOPYRAN-3-YL)METHYLENE]HYDRAZINECARBOTHIOAMIDE COPPER COMPLEX FPA 124 Akt Inhibitor (FPA-124) FPA 124,FPA124 902779-59-3 C11H9Cl2CuN3O2S Intracellular Signaling