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Grape Seed Extract

Grape Seed Extract Structure
CAS No.
84929-27-1
Chemical Name:
Grape Seed Extract
Synonyms
Proanthocyanidin;GSE;GRAPE SEED;Vitis vinifera leaf extract;VITIS VINIFERA (GRAPE) LEAF EXTRACT;Grape skin;NataPres GS;Grape seed dry;Unii-T3pw93ib4q;Grape, red, ext.
CBNumber:
CB6258001
Molecular Formula:
C32H30O11
Molecular Weight:
590.574
MOL File:
84929-27-1.mol
Modify Date:
2024/7/2 8:55:13
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Grape Seed Extract Properties

Density 0.961g/cm3 at 20℃
vapor pressure 0.003Pa at 60℃
FEMA 4045 | GRAPE SEED EXTRACT
storage temp. Inert atmosphere,Room Temperature
solubility Soluble in DMSO
form Solid:particulate/powder
color Brown to reddish brown
LogP 6.5 at 25℃ and pH5-6

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS02
Signal word  Warning
Hazard statements  H225
Precautionary statements  P210-P233-P240-P241-P242-P243-P280-P303+P361+P353-P370+P378-P403+P235-P501

Grape Seed Extract Chemical Properties,Uses,Production

Chemical Properties

Grape seed extract has an astrigent taste.

Occurrence

Grapeseed is found throughout the world.

Uses

Grape seed extract is a natural product, with anti-inflammatory and anti-proliferative effects. Grape seed extract shows inhibitory activity on the fat-metabolizing enzymes pancreatic lipase and lipoprotein lipase. Grape seed extract induces apoptotic in human colorectal cancer cells.

Anticancer Research

Grape seed extract (GSE) has high quantities of proanthocyanidins and resveratrol.Human colorectal cancer cell (CRC) exposure to GSE (Schonthal 2012) resulted inmodified ER chaperones glucose-related protein-78 (GRP78) and protein disulphideisomerase (PDI). GRP78 is needed for integrity of ER as well as stress-inducedautophagy (Flaumenhaft et al. 2015). PDI, a thiol-disulphide oxidoreductase,catalyses the disulphide bonds in newly synthesized proteins in the ER lumen (Hanet al. 2013; Wang and Kaufman 2014; Perri et al. 2016), and PDIA3 is localized tothe ER and is involved in protein folding (Wang et al. 2012b). Studies on the role ofPDI in cancer have demonstrated a pro-oncogenic, pro-survival role for PDI incancer and therapeutic resistance. PDI aids in ameliorating stress-induced apoptosisand causes degradation of wrongly folded proteins (Dinicola et al. 2010; Xu et al.2014). Hence, any obstruction caused in the activity of PDI will induce stress in thecell and lead to cell apoptosis. Fructose bisphosphate aldolase, a key enzymeinvolved in glycolysis, is also a potential target of GSE (Vandewynckel et al. 2016).The ER stress leads the cell to undergo apoptotic pathways in multiple ways andhence inhibits the proliferation of the targeted cells (Farooqi et al. 2015).

Grape Seed Extract Preparation Products And Raw materials

Raw materials

Preparation Products

Grape Seed Extract Suppliers

Global( 367)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Venbiotech +91-9344202656 +91-9940417693 Tamil Nadu, India 14 58 Inquiry
Apollo ingredients Pvt Ltd +91-7219888886 Maharashtra, India 31 58 Inquiry
Bioextract +91-8042633900 +91-9620333000 Karnataka, India 19 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
The Bangalore Sales Corporation 08046039327 Karnataka, India 7 58 Inquiry
Ozone Ingredients 08048250471Ext 902 Gujarat, India 17 58 Inquiry
Quality Products Lab Private Limited 08048250471Ext 345 Uttar Pradesh, India 43 58 Inquiry
Centaur Exports 08048372006Ext 640 Madhya Pradesh, India 11 58 Inquiry
Strides Pharma Science 08402016501 Karnataka, India 5 58 Inquiry
Changsha Staherb Natural Ingredients Co., Ltd. +86-0731-84213302 +86-18374838656 China 1025 58 Inquiry
Supplier Advantage
Venbiotech 58
Apollo ingredients Pvt Ltd 58
Bioextract 58
CLEARSYNTH LABS LTD. 58
The Bangalore Sales Corporation 58
Ozone Ingredients 58
Quality Products Lab Private Limited 58
Centaur Exports 58
Strides Pharma Science 58
Changsha Staherb Natural Ingredients Co., Ltd. 58

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