3-(cyclopropylMethyl)-7-(4-phenylpiperidin-1-yl)-8-(trifluoroMethyl)-[1,2,4]triazolo[4,3-a]pyridine
![3-(cyclopropylMethyl)-7-(4-phenylpiperidin-1-yl)-8-(trifluoroMethyl)-[1,2,4]triazolo[4,3-a]pyridine Structure](CAS/GIF/1254977-87-1.gif)
- CAS No.
- 1254977-87-1
- Chemical Name:
- 3-(cyclopropylMethyl)-7-(4-phenylpiperidin-1-yl)-8-(trifluoroMethyl)-[1,2,4]triazolo[4,3-a]pyridine
- Synonyms
- CS-2446;JNJ42153605 (on going);JNJ-42153605;JNJ42153605;Inhibitor,JNJ42153605,Metabotropic glutamate receptors,JNJ-42153605,inhibit,JNJ 42153605,mGluR;3-(cyclopropylMethyl)-7-(4-phenylpiperidin-1-yl)-8-(trifluoroMethyl)-[1,2,4]triazolo[4,3-a]pyridine;3-(Cyclopropylmethyl)-7-(4-phenyl-1-piperidinyl)-8-(trifluorometh yl)[1,2,4]triazolo[4,3-a]pyridine;1,2,4-Triazolo[4,3-a]pyridine, 3-(cyclopropylmethyl)-7-(4-phenyl-1-piperidinyl)-8-(trifluoromethyl)-
- CBNumber:
- CB62618641
- Molecular Formula:
- C22H23F3N4
- Molecular Weight:
- 400.44
- MOL File:
- 1254977-87-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/2 8:55:13
3-(cyclopropylMethyl)-7-(4-phenylpiperidin-1-yl)-8-(trifluoroMethyl)-[1,2,4]triazolo[4,3-a]pyridine Properties
Density | 1.38±0.1 g/cm3(Predicted) |
---|---|
storage temp. | Store at -20°C |
solubility |
DMF:30.0(Max Conc. mg/mL);74.92(Max Conc. mM) DMF:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.62(Max Conc. mM) DMSO:10.34(Max Conc. mg/mL);25.81(Max Conc. mM) Ethanol:10.0(Max Conc. mg/mL);24.97(Max Conc. mM) |
form | A crystalline solid |
pka | 3.07±0.30(Predicted) |
color | White to off-white |
3-(cyclopropylMethyl)-7-(4-phenylpiperidin-1-yl)-8-(trifluoroMethyl)-[1,2,4]triazolo[4,3-a]pyridine Chemical Properties,Uses,Production
Description
JNJ-42153605 is a positive allosteric modulator of metabotropic glutamate receptor 2 (mGluR2; EC50 = 17 nM in CHO cells expressing the human receptor). In vivo, JNJ-42153605 (3 mg/kg) inhibits mGluR2-mediated rapid eye movement (REM) sleep in rats. It also reverses phencyclidine-induced hyperlocomotion in mice (ED50 = 5.4 mg/kg).
3-(cyclopropylMethyl)-7-(4-phenylpiperidin-1-yl)-8-(trifluoroMethyl)-[1,2,4]triazolo[4,3-a]pyridine Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 40)Suppliers
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3-(cyclopropylMethyl)-7-(4-phenylpiperidin-1-yl)-8-(trifluoroMethyl)-[1,2,4]triazolo[4,3-a]pyridine Spectrum
1254977-87-1(3-(cyclopropylMethyl)-7-(4-phenylpiperidin-1-yl)-8-(trifluoroMethyl)-[1,2,4]triazolo[4,3-a]pyridine)Related Search:
3-(cyclopropylMethyl)-7-(4-phenylpiperidin-1-yl)-8-(trifluoroMethyl)-[1,2,4]triazolo[4,3-a]pyridine
JNJ42153605 (on going)
JNJ-42153605;JNJ42153605
CS-2446
3-(Cyclopropylmethyl)-7-(4-phenyl-1-piperidinyl)-8-(trifluorometh yl)[1,2,4]triazolo[4,3-a]pyridine
1,2,4-Triazolo[4,3-a]pyridine, 3-(cyclopropylmethyl)-7-(4-phenyl-1-piperidinyl)-8-(trifluoromethyl)-
Inhibitor,JNJ42153605,Metabotropic glutamate receptors,JNJ-42153605,inhibit,JNJ 42153605,mGluR
1254977-87-1
C22H23F3N4