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RO-32-0432

RO-32-0432 Structure
CAS No.
151342-35-7
Chemical Name:
RO-32-0432
Synonyms
RO-32-0432;Ro 31-0432;RO 32-0432 HCL;RO 32-0432 HYDROCHLORIDE;BISINDOLYLMALEIMIDE XI, HCL;BISINDOLYLMALEIMIDE XL, HCL;BISINDOYLMALEIMIDE XI HYDROCHLORIDE;BISINDOLYLMALEIMIDE XI HYDROCHLORIDE;Ro 32 0432 hydrochloride,Ro 320432 hydrochloride;BisindolylMaleiMide XI . hydrochloride [Ro 32-0432]
CBNumber:
CB6262512
Molecular Formula:
C28H28N4O2
Molecular Weight:
452.55
MOL File:
151342-35-7.mol
MSDS File:
SDS
Modify Date:
2023/5/18 11:31:17
Request For Quotation

RO-32-0432 Properties

Boiling point 712.2±60.0 °C(Predicted)
Density 1.32±0.1 g/cm3(Predicted)
storage temp. −20°C
solubility DMSO: soluble
form solid
pka 7.91±0.60(Predicted)
color orange

SAFETY

Risk and Safety Statements

WGK Germany  3
HS Code  3822000000

RO-32-0432 Chemical Properties,Uses,Production

Uses

Bisindolylmaleimide XI is a potent and selective cell-permeable protein kinase C (PKC) inhibitor. Studies reveal that inhibition of PKCα by Bisindolylmaleimide XI and other similar PKC inhibitors has been associated with enhanced cardiac contractility and protection from heart failure. Bisindolylmaleimide XI has been shown to prevent T-cell activation and proliferation associated with chronic infl ammatory responses in vivo.

Biological Activity

Selective cell-permeable protein kinase C inhibitor. Displays slight selectivity for conventional PKC isoforms over Ca 2+ and atypical PKC isoforms; binding affinities for rat isoforms are 9, 28, 31, 37 and 108 nM for PKC's α , β Ι, β ΙΙ, γ and ε respectively. Orally available and prevents T-cell chronic inflammation in vivo .

RO-32-0432 Preparation Products And Raw materials

Raw materials

Preparation Products

RO-32-0432 Suppliers

Global( 53)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
Career Henan Chemica Co +86-0371-86658258 +8613203830695 China 30253 58 Inquiry
United States Biological 800.520.3011 or 781.639.5092 United States 6256 80 Inquiry
Beijing Lebo Biotechnology Co., Ltd. 010-50934026 CHINA 6057 58 Inquiry
MedBioPharmaceutical Technology Inc 021-69568360 18916172912 China 8141 58 Inquiry
TargetMol Chemicals Inc. 4008200310 China 23963 58 Inquiry
Jinan Ruisi Pharmaceutical Technology Co., LTD 0531-69900633 18340090523 China 1979 58 Inquiry
Kanto Chemical Co., Inc. +81 3 3663 7631 Japan 6762 74 Inquiry
BIOMOL INTERNATIONAL, LP (800) 942-0430 United States 1503 77 Inquiry
Alexis Corporation +41 61 926 8989 Switzerland 3599 74 Inquiry
Supplier Advantage
TargetMol Chemicals Inc. 58
Career Henan Chemica Co 58
United States Biological 80
Beijing Lebo Biotechnology Co., Ltd. 58
MedBioPharmaceutical Technology Inc 58
TargetMol Chemicals Inc. 58
Jinan Ruisi Pharmaceutical Technology Co., LTD 58
Kanto Chemical Co., Inc. 74
BIOMOL INTERNATIONAL, LP 77
Alexis Corporation 74

151342-35-7(RO-32-0432)Related Search:

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RARECHEM AN KA 0813 RO-32-0432
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RO-32-0432 RO 32-0432 HCL RO 32-0432 HYDROCHLORIDE BISINDOLYLMALEIMIDE XI, HCL BISINDOLYLMALEIMIDE XI HYDROCHLORIDE BISINDOLYLMALEIMIDE XL, HCL BISINDOYLMALEIMIDE XI HYDROCHLORIDE 2-[8-[(DIMETHYLAMINO)METHYL]-6,7,8,9-TETRAHYDROPYRIDO[1,2-A]INDOL-3-YL]-3-(1-METHYL-1H-INDOL-3-YL)MALEIMIDE, HCL 2-(8-[(DIMETHYLAMINO)METHYL]-6,7,8,9-TETRAHYDROPYRIDO[1,2-A]INDOL-3-YL)-3-(1-METHYLINDOL-3-YL)MALEIMIDE HYDROCHLORIDE (S)-3-[8-[(Dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione 1H-Pyrrol-2,5-dione, 3-(8-((dimethylamino)methyl)-6,7,8,9-tetrahydropy rido(1,2-a)indol-10-yl)-4-(1-methyl-1H-indol-3-yl)-, (S)- Bisindoylmaleimide XI: 2-(8-[(Dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-3-yl)-3-(1-methylindol-3-yl)maleimide 3-[(8S)-8-[(Dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dionehydrochloride 3-[8-[(DiMethylaMino)Methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-Methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione Hydrochloride Ro 31-0432 BisindolylMaleiMide XI . hydrochloride [Ro 32-0432] 1H-Pyrrole-2,5-dione, 3-[(8S)-8-[(dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methyl-1H-indol-3-yl)- Ro 32 0432 hydrochloride,Ro 320432 hydrochloride 151342-35-7 C28H28N4O2HCl C28H28N4O2ClH inhibitor