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ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Angiogenesis >FLT3 inhibitors >G-749

G-749

G-749 Structure
CAS No.
1457983-28-6
Chemical Name:
G-749
Synonyms
G-49;G-749;CS-3343;CS-1812;G-749, >=98%;Denfivontinib;G-749 USP/EP/BP;G-749 (Free base);G-749; G749; G 749; CS-3343;8-bromo-2-((1-methylpiperidin-4-yl)amino)-4-((4-phenoxyphenyl)amino)pyrido[4,3-d]pyrimidin-5(6H)-one
CBNumber:
CB62715629
Molecular Formula:
C25H25BrN6O2
Molecular Weight:
521.41
MOL File:
1457983-28-6.mol
MSDS File:
SDS
Modify Date:
2024/7/2 8:55:13
Request For Quotation

G-749 Properties

Density 1.487±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility ≥26.05 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
form solid
pka 8.32±0.40(Predicted)
color White to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
NFPA 704
0
2 0

G-749 Chemical Properties,Uses,Production

Description

G-749 is an inhibitor of Fms-like tyrosine receptor kinase 3 (FLT3) with IC50 values ranging from 2.1 to 38.1 nM for wild-type and mutant (constitutively active) FLT3s in Ba/F3 cells expressing recombinant receptors. It also inhibits growth of human leukemia cell lines that express FLT3-ITD mutant kinase (IC50s = 3.5 and 7.5 nM for MV4-11 and Molm-14 cells, respectively) but has no effect on cells that lack FLT3 expression or that express wild-type FLT3. G-749 reduces tumor growth and increases survival in a dose-dependent manner in MV4-11 and Molm-14 murine leukemia xenograft models. It reduces growth of bone marrow blasts derived from acute myeloid leukemia patients, showing more potent inhibition of blasts expressing the FLT3-ITD mutant receptor.

Uses

G-749 is a potent FLT3 inhibitor. It shows lower potency against other tyrosine kinases.

G-749 Preparation Products And Raw materials

Raw materials

Preparation Products

G-749 Suppliers

Global( 92)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29826 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
Dideu Industries Group Limited +86-29-89586680 +86-15129568250 China 25247 58 Inquiry
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 +1-2135480471 China 10522 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
ShenZhen Trendseen Biological Technology Co.,Ltd. 13417589054 China 11681 58 Inquiry
Aladdin Scientific +1-+1(833)-552-7181 United States 57511 58 Inquiry
Amadis Chemical Company Limited 571-89925085 China 131980 58 Inquiry
Supplier Advantage
CLEARSYNTH LABS LTD. 58
ATK CHEMICAL COMPANY LIMITED 60
career henan chemical co 58
TargetMol Chemicals Inc. 58
Dideu Industries Group Limited 58
Zhejiang J&C Biological Technology Co.,Limited 58
InvivoChem 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 58
Aladdin Scientific 58
Amadis Chemical Company Limited 58

G-749 Spectrum

G-749(1457983-28-6)1HNMR

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G-49 G-749 (Free base) G-749 8-Bromo-2-[(1-methyl-4-piperidinyl)amino]-4-[(4-phenoxyphenyl)amino]pyrido[4,3-d]pyrimidin-5(6H)-one 8-Bromo-2-[(1-methyl-4-piperidinyl)amino]-4-[(4-phenoxyphenyl)amino]pyrido[4,3-d]pyrimidin-5(6H)-one G749 G-749, >=98% 8-bromo-2-((1-methylpiperidin-4-yl)amino)-4-((4-phenoxyphenyl)amino)pyrido[4,3-d]pyrimidin-5(6H)-one Pyrido[4,3-d]pyrimidin-5(6H)-one, 8-bromo-2-[(1-methyl-4-piperidinyl)amino]-4-[(4-phenoxyphenyl)amino]- CS-1812 CS-3343 G-749; G749; G 749; CS-3343 G-749 USP/EP/BP resistance,tyrosine,AML,G-749,FLT3,acute,kinase,myeloid,G 749,Cluster of differentiation antigen 135,inhibit,receptor,Inhibitor,leukemia,drug,Fms like tyrosine kinase 3,Fms-like,CD135,Apoptosis Denfivontinib 1457983-28-6 C25H25BrN6O2 Inhibitors API