NPGB

CAS No.: 19135-17-2

Chemical Name:: NPGB

Synonyms: NPGB;PNPGB;Nsc163801;P-NITROPHENYL P'-GUANIDINOBENZOATE HCL;4-NITROPHENYL 4-GUANIDINOBENZOATE &;4-NITROPHENYL 4-GUANIDINOBENZOATE HYDROCHLORIDE;P-NITROPHENYL-P-GUANIDINOBENZOATE HYDROCHLORIDE;P-NITROPHENYL P'-GUANIDINOBENZOATE HYDROCHLORIDE;p-nitrophenyl-p'-guanidinobenzoateHClcrystalline;4-GUANIDINOBENZOIC ACID 4-NITROPHENYL-ESTER HYDROCHLORIDE

CBNumber:: CB6287205

Molecular Formula:: C14H13ClN4O4

Molecular Weight:: 336.73

MOL File:: 19135-17-2.mol

Modify Date:: 2024/7/2 8:55:13

Request For Quotation

NPGB Properties

Melting point	241-243 °C
storage temp.	-20°C
form	Solid
color	White to off-white
BRN	8024554

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS05
Signal word	Danger
Hazard statements	H318
Precautionary statements	P280-P305+P351+P338
Hazard Codes	Xi
Risk Statements	36
Safety Statements	26
WGK Germany	3
F	8-10

NPGB price More Price(2)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	N8010	4-Nitrophenyl 4-guanidinobenzoate hydrochloride protease inhibitor and substrate	19135-17-2	500MG	₹22570.13	2022-06-14	Buy
Sigma-Aldrich(India)	N8010	4-Nitrophenyl 4-guanidinobenzoate hydrochloride protease inhibitor and substrate	19135-17-2	1G	₹37238	2022-06-14	Buy

Product number	Packaging	Price	Buy
N8010	500MG	₹22570.13	Buy
N8010	1G	₹37238	Buy

NPGB Chemical Properties,Uses,Production

Uses

4-Nitrophenyl 4-guanidinobenzoate hydrochloride has been used:

as a substrate for trypsin for active site titration experiments
for pre-treating of mosquito eggs in the interplasmid transposition assay
as a component of isotonic buffer to moisten filter paper for mosquito embryo collection

General Description

4-Nitrophenyl 4-guanidinobenzoate hydrochloride (pNPGB) is a trypsin substrate. It is more water-soluble than 4-methylumbelliferyl 4-guanidinobenzoate and is preferred in spectrophotometric assay.

Biochem/physiol Actions

4-Nitrophenyl 4-guanidinobenzoate hydrochloride (pNPGB) inhibits phenoloxidase enzyme and delays embryo chorionic membrane hardening.

References

[1] BHUMI PATEL . L. donovani XPRT: Molecular characterization and evaluation of inhibitors[J]. Biochimica et biophysica acta. Proteins and proteomics, 2018, 1866 3: Pages 426-441. DOI:10.1016/j.bbapap.2017.12.002.
[2] FRANK S. STEVEN Margaret M G. Studies on the Molecular Mechanism of Mersalyl and 4-Aminophenylmercuric Acetate Re-activation of Trypsin-Thiol Complexes[J]. The FEBS journal, 1980, 109 2: 567-573. DOI:10.1111/j.1432-1033.1980.tb04829.x.
[3] YING-YING HE . Isolation, expression and characterization of a novel dual serine protease inhibitor, OH-TCI, from king cobra venom[J]. Peptides, 2008, 29 10: Pages 1692-1699. DOI:10.1016/j.peptides.2008.05.025.
[4] J.A. SCHIFFERLI G. S. A simple two-step procedure for the preparation of the first component of human complement (C1) in its native form[J]. Journal of immunological methods, 1985, 76 2: Pages 283-288. DOI:10.1016/0022-1759(85)90305-9.
[5] J. M. KAMINSKI. Synthesis and inhibition of human acrosin and trypsin and acute toxicity of aryl 4-guanidinobenzoates[J]. Journal of Medicinal Chemistry, 1986, 29 4: 514-519. DOI:10.1021/jm00154a015.

NPGB Preparation Products And Raw materials

Raw materials

Preparation Products

NPGB Suppliers

Global( 14)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
MP Biomedicals, Inc.	949 833 2500	United States	6566	81	Inquiry
Research Organics Inc.	800 321-0570	United States	1324	72	Inquiry
Nacalai Tesque, Inc.	81 75 251 1723	Japan	6048	75	Inquiry
CHEMICAL LAND21	82- 2 -783 - 8063	South Korea	6315	74	Inquiry
Service Chemical Inc.	888-895-6920	Germany	6373	71	Inquiry
SIGMA-RBI	800 736 3690 (Orders)	Switzerland	6913	91	Inquiry
Riedel-de Haen AG	800 558-9160	United States	6825	87	Inquiry
Shaanxi Dideu Newmaterial Co., Ltd.	029-63373950 15353716720	China	10011	58	Inquiry
Shanghai Yingxin laboratory equipment Co., Ltd	021-021-59178156 15300768757	China	10678	58	Inquiry
Shanghai Guchen Biotechnology Co., LTD	021-34675735 19147740836	China	9849	58	Inquiry

Supplier	Advantage
MP Biomedicals, Inc.	81
Research Organics Inc.	72
Nacalai Tesque, Inc.	75
CHEMICAL LAND21	74
Service Chemical Inc.	71
SIGMA-RBI	91
Riedel-de Haen AG	87
Shaanxi Dideu Newmaterial Co., Ltd.	58
Shanghai Yingxin laboratory equipment Co., Ltd	58
Shanghai Guchen Biotechnology Co., LTD	58

19135-17-2(NPGB)Related Search:

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METHYL 4-METHYLAMINOBENZOATE 1-BENZYLOXY-4-NITROBENZENE 4-NITROPHENYL BENZOATE 4-Benzyloxyaniline hydrochloride Phenyl benzoate

PHENYL 4-AMINOBENZOATE N-P-TOLYL-GUANIDINE HYDROCHLORIDE P-PHENETIDINE HYDROCHLORIDE N-P-TOLYL-GUANIDINE NPGB

METHYL 4-AMINOBENZOATE HYDROCHLORIDE 4-(PHENOXYMETHYL)ANILINE 4-nitrophenyl 4'-guanidinobenzoate

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4-GUANIDINOBENZOIC ACID 4-NITROPHENYL-ESTER HYDROCHLORIDE 4-NITROPHENYL 4-GUANIDINOBENZOATE HYDROCHLORIDE NPGB PNPGB P-NITROPHENYL P'-GUANIDINOBENZOATE HYDROCHLORIDE P-NITROPHENYL-P-GUANIDINOBENZOATE HYDROCHLORIDE P'-GUANIDINOBENZOIC ACID P-NITROPHENYL ESTER HYDROCHLORIDE Nsc163801 4-nitrophenyl 4-[(aminoiminomethyl)amino]benzoate monohydrochloride P-NITROPHENYL P'-GUANIDINOBENZOATE HCL 4-NITROPHENYL 4-GUANIDINOBENZOATE & p-nitrophenyl-p'-guanidinobenzoateHClcrystalline p-Nitrophenyl-p'-guanidinobenzoatehydrochloridecrystalline Benzoic acid, 4-(aminoiminomethyl)amino-, 4-nitrophenyl ester, monohydrochloride 4-Guanidinobenzoic acid 4-nitrophenylester hydrochloride, NPGB, pNPGB (4-nitrophenyl)4-(diaminomethylideneamino)benzoate,hydrochloride 4-Nitrophenyl 4-guanidinobenzoate hydrochloride protease inhibitor and substrate 19135-17-2 C14H12N4O4HCl Substrates by Enzyme Chromogenic Enzymes, Inhibitors, and Substrates Enzyme Substrates Activity BioChemical Biochemicals and Reagents