daprodustat,GSK1278863

daprodustat,GSK1278863 Structure
CAS No.
960539-70-2
Chemical Name:
daprodustat,GSK1278863
Synonyms
CS-1541;GSK1278863;Daprodustat;GSK 1278863 NEW;GSK1278863, >98%;Daprodustat, >98%;13C12]-Daprodustat;GSK1278863,daprodustat;daprodustat,GSK1278863;Daprodustat Impurity 3
CBNumber:
CB63038532
Molecular Formula:
C19H27N3O6
Molecular Weight:
393.43
MOL File:
960539-70-2.mol
Modify Date:
2023/12/21 9:33:13

daprodustat,GSK1278863 Properties

Melting point 237-241oC
Density 1.359±0.06 g/cm3(Predicted)
storage temp. Refrigerator
solubility Chloroform (Slightly), DMSO (Slightly)
pka 3.44±0.10(Predicted)
form Solid
color White to Off-White

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319
Precautionary statements  P501-P270-P264-P280-P337+P313-P305+P351+P338-P302+P352-P332+P313-P362-P301+P310+P330-P405

daprodustat,GSK1278863 Chemical Properties,Uses,Production

Uses

Daprodustat is a novel HIF (Hypoxia inducible factor)-prolyl hydroxylase inhibitor.

daprodustat,GSK1278863 Preparation Products And Raw materials

Raw materials

Preparation Products

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  • Synthesis of Daprodustat
  • Daprodustat is synthesised using malonic acid as a raw material by Biginelli reaction, saponification and other reactions.
  • Dec 21,2023

daprodustat,GSK1278863 Spectrum

daprodustat,GSK1278863 GSK1278863 Daprodustat 2-(1,3-dicyclohexyl-2,4,6-trioxohexahydropyrimidine-5-carboxamido)acetic acid N-[(1,3-Dicyclohexylhexahydro-2,4,6-trioxo-5-pyrimidinyl)carbonyl]glycine GSK1278863; GSK 1278863; GSK-1278863; DAPRODUSTAT 2-[(1,3-dicyclohexyl-2,4,6-trioxo-1,3-diazinane-5-carbonyl)amino]acetic acid GSK1278863,daprodustat CS-1541 Daprodustat, >98% GSK1278863, >98% (1,3-dicyclohexyl-2,4,6-trioxohexahydropyrimidine-5-carbonyl)glycine GSK 1278863 NEW Glycine, N-[(1,3-dicyclohexylhexahydro-2,4,6-trioxo-5-pyrimidinyl)carbonyl]- Daprodustat Impurity 3 13C12]-Daprodustat 960539-70-2 API