ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >PI3K / Akt / mTOR >PI3K inhibitor >GSK-2126458
GSK-2126458
- CAS No.
- 1086062-66-9
- Chemical Name:
- GSK-2126458
- Synonyms
- CS-55;GSK458;GSK212;HYR-582;OMipalisib;GSK2126458;GSK-2126458;GSK2126458, >=98%;Omipalisib GSK458;GSK2126458 (GSK458)
- CBNumber:
- CB92505205
- Molecular Formula:
- C25H17F2N5O3S
- Molecular Weight:
- 505.5
- MOL File:
- 1086062-66-9.mol
- Modify Date:
- 2023/6/30 15:45:59
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H361fd-H372 | |||||||||
| Precautionary statements | P202-P260-P264-P270-P301+P312-P308+P313 | |||||||||
| HS Code | 29350090 | |||||||||
| NFPA 704 |
|
GSK-2126458 price More Price(2)
GSK-2126458 Chemical Properties,Uses,Production
Description
GSK2126458 is a potent inhibitor of phosphoinositide 3-kinase isoforms (Kis = 19, 130, 24, and 60 pM for p110α, β, δ, and γ, respectively). It also inhibits mTOR in both mTORC1 and mTORC2 (Kis = 180 and 300 nM, respectively), as well as several common mutant forms of p110α. GSK2126458 is orally bioavailable, displays favorable pharmacokinetics, and shows efficacy in tumor growth models. GSK2126458 positively combines with inhibitors of discoidin domain receptor 1 (DDR1) inhibitor DDR1-IN-1 to suppress the growth of SNU-1040 colorectal cancer cells.
Uses
A highly potent inhibitor of PI3K and the mammalian target of Rapamycin.
GSK-2126458 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 166)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | China | 29798 | 60 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32836 | 60 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29888 | 58 | Inquiry |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | China | 39916 | 58 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49392 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 24099 | 58 | Inquiry |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | China | 10522 | 58 | Inquiry |
1086062-66-9(GSK-2126458)Related Search:
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GSK2126458
GSK-2126458
GSK2126458; GSK-2126458
2,4-Difluoro-N-[2-methoxy-5-[4-(4-pyridazinyl)-6-quinolinyl]-3-pyridinyl]benzenesulfonamide
HYR-582
GSK212
2,4-Difluoro-N-[2-Methoxy-5-[4-(pyridazin-4-yl)quinolin-6-yl]pyridin-3-yl]benzenesulfonaMide
OMipalisib
GSK458
Omipalisib (GSK2126458, GSK458)
2,4-Difluoro-N-[2-methoxy-5-[4-(4-pyridazinyl)-6-quinolinyl]-3-pyridinyl]benzenesulfonamide GSK2126458(GSK458)
GSK 2126458
2,4-Difluoro-N-[2-methoxy-5-[4-(4-pyridazinyl)-6-quinolinyl]-3-pyridinyl]benzenesulfonamide
2,4-difluoro-N-{2-(methyloxy)-5-[4-(4-pyridazinyl)-6-quinolinyl]-3-pyridinyl}benzenesulfonamide
GSK2126458 (GSK458)
GSK2126458, >=98%
GSK2126458(Omipalisib)
GSK2126458 (GSK458);GSK458;GSK-212; GSK-2126458
GSK2126458 (HYR-582)
CS-55
Omipalisib GSK2126458
Omipalisib, 98%, a highly selective and potent inhibitor of PI3K
Omipalisib GSK458
Benzenesulfonamide, 2,4-difluoro-N-[2-methoxy-5-[4-(4-pyridazinyl)-6-quinolinyl]-3-pyridinyl]-
GSK-2126458 USP/EP/BP
Omipalisib GSK2126458 GSK-2126458
1086062-66-9
C25H17F2N5O3S
Akt
mTOR
PI3K
Inhibitors
PI3K/Akt/mTOR
Aromatics
Heterocycles
Intermediates & Fine Chemicals
Pharmaceuticals
Sulfur & Selenium Compounds