GSK-2126458
- ₹9417.75 - ₹37952.45
- Product name: GSK-2126458
- CAS: 1086062-66-9
- MF: C25H17F2N5O3S
- MW: 505.5
- EINECS:629-873-1
- MDL Number:MFCD16038929
- Synonyms:GSK2126458;GSK-2126458;GSK2126458; GSK-2126458;2,4-Difluoro-N-[2-methoxy-5-[4-(4-pyridazinyl)-6-quinolinyl]-3-pyridinyl]benzenesulfonamide;HYR-582;GSK212;2,4-Difluoro-N-[2-Methoxy-5-[4-(pyridazin-4-yl)quinolin-6-yl]pyridin-3-yl]benzenesulfonaMide;OMipalisib
2 prices
Selected condition:
Brand
- Sigma-Aldrich(India)
Package
- 10MG
- 50MG
- ManufacturerSigma-Aldrich(India)
- Product numberSML3161
- Product descriptionGSK2126458 ≥98% (HPLC)
- Packaging10MG
- Price₹9417.75
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberSML3161
- Product descriptionGSK2126458 ≥98% (HPLC)
- Packaging50MG
- Price₹37952.45
- Updated2022-06-14
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
Sigma-Aldrich(India) | SML3161 | GSK2126458 ≥98% (HPLC) | 10MG | ₹9417.75 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | SML3161 | GSK2126458 ≥98% (HPLC) | 50MG | ₹37952.45 | 2022-06-14 | Buy |
Properties
Melting point :187-189℃
Boiling point :715.6±70.0 °C(Predicted)
Density :1.45
storage temp. :Refrigerator
solubility :Chloroform (Slightly), DMSO (Slightly), Methanol (Very Slightly, Heated)
form :Solid
pka :6.23±0.40(Predicted)
color :White to Pale Yellow
Boiling point :715.6±70.0 °C(Predicted)
Density :1.45
storage temp. :Refrigerator
solubility :Chloroform (Slightly), DMSO (Slightly), Methanol (Very Slightly, Heated)
form :Solid
pka :6.23±0.40(Predicted)
color :White to Pale Yellow
Safety Information
Symbol(GHS): | ||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Signal word: | Danger | |||||||||||||||||||||
Hazard statements: |
|
|||||||||||||||||||||
Precautionary statements: |
|
Description
GSK2126458 is a potent inhibitor of phosphoinositide 3-kinase isoforms (Kis = 19, 130, 24, and 60 pM for p110α, β, δ, and γ, respectively). It also inhibits mTOR in both mTORC1 and mTORC2 (Kis = 180 and 300 nM, respectively), as well as several common mutant forms of p110α. GSK2126458 is orally bioavailable, displays favorable pharmacokinetics, and shows efficacy in tumor growth models. GSK2126458 positively combines with inhibitors of discoidin domain receptor 1 (DDR1) inhibitor DDR1-IN-1 to suppress the growth of SNU-1040 colorectal cancer cells.More related product prices
LY 294002 HYDROCHLORIDE Erlotinib hydrochloride Pictilisib (GDC-0941) MK-2206 2HCl AZD-8055 Cadmium sulfide 1337531-36-8 GSK1292263 349085-82-1 4-(4-fluorophenyl)-N-(1H-indazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide daprodustat,GSK1278863 Danirixin BEZ235 (NVP-BEZ235, Dactolisib) 942206-85-1 AVE8062A Olmutinib OMecaMtiv Mecarbil ABT 702 Dihydrochloride 6-[[3-[(Dimethylamino)carbonyl]phenyl]sulfonyl]-4-[(3-methoxyphenyl)amino]-8-methyl-3-quinolinecarboxamide GSK2636771Related product price
- LY 294002 HYDROCHLORIDE
₹10660-37350 - Cadmium sulfide
₹900-63594 - 349085-82-1
₹8908-44339.2
Suppliers and manufacturers
A.J Chemicals
Pharmaffiliates Analytics and Synthetics P. Ltd
Capot Chemical Co.,Ltd.
ATK CHEMICAL COMPANY LIMITED
Chongqing Chemdad Co., Ltd
CONIER CHEM AND PHARMA LIMITED
TargetMol Chemicals Inc.
Dideu Industries Group Limited
Zhejiang J&C Biological Technology Co.,Limited