Olmutinib
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- ₹0
- Product name: Olmutinib
- CAS: 1353550-13-6
- MF: C26H26N6O2S
- MW: 486.59
- EINECS:-0
- MDL Number:
- Synonyms:HM71224;HM-71224;Olmutinib;Olmutinib, HM71224;N-(3-(2-(4-(4-methylpiperazin-1-yl)phenylamino)thieno[3,2-d]pyrimidin-4-yloxy)phenyl)acrylamide dihydrochloride monohydrate;N-(3-(2-(4-(4-methylpiperazin-1-yl)phenylamino)thieno[3,2-d]pyrimidin-4-yloxy)phenyl)acrylamide;N-[3-[[2-[[4-(4-Methyl-1-piperazinyl)phenyl]amino]thieno[3,2-d]pyrimidin-4-yl]oxy]phenyl]-2-propenamide;HM71224, Olmutinib
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Properties
Density :1.336±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :insoluble in H2O; ≥9.11 mg/mL in EtOH with ultrasonic; ≥96.6 mg/mL in DMSO
form :crystalline solid
pka :12.87±0.70(Predicted)
color :Light yellow to yellow
storage temp. :Store at -20°C
solubility :insoluble in H2O; ≥9.11 mg/mL in EtOH with ultrasonic; ≥96.6 mg/mL in DMSO
form :crystalline solid
pka :12.87±0.70(Predicted)
color :Light yellow to yellow
Safety Information
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Description
HM71224 is an inhibitor of Bruton's tyrosine kinase (BTK; IC50 = 1.95 nM) that has been shown to prevent B cell activation and osteoclastogenesis. It additionally targets the related kinases BMX, Tec, and TXK (IC50s = 0.64, 4.57, and 4.62 nM, respectively), as well as EGFR (IC50 = 4.96 nM). In a mouse model of rheumatoid arthritis, 3-30 mg/kg HM71224 dose dependently reduced erosive bone changes and prevented bone loss.Related product price
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