EGF816
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- ₹0
- Product name: EGF816
- CAS: 1508250-71-2
- MF: C26H31ClN6O2
- MW: 495.02
- EINECS:
- MDL Number:MFCD28963918
- Synonyms:Nazartinib (EGF816);EGF816;Nazartinib;NVS-816;EGF816, 98%, a novel EGFR inhibitor;Nazartinib (EGF816, NVS-816);(R,E)-N-(7-chloro-1-(1-(4-(dimethylamino)but-2-enoyl)azepan-3-yl)-1H-benzo[d]imidazol-2-yl)-2-methylisonicotinamide;EGF816 Nazartinib
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
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Properties
Density :1.28±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :Soluble in DMSO
form :Powder
pka :11.38±0.43(Predicted)
color :Off-white to yellow
storage temp. :Store at -20°C
solubility :Soluble in DMSO
form :Powder
pka :11.38±0.43(Predicted)
color :Off-white to yellow
Safety Information
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Description
Nazartinib is an irreversible inhibitor of mutant EGF receptors (EGFRs). It is selective for EGFR mutant cell lines, including H3255 and HCC827 lung adenocarcinoma cells (IC50s = 6.11 and 1.52 nM, respectively) and resistant H1975 non-small cell lung cancer cells (NSCLC; IC50 = 4.18 nM), over cells expressing wild-type EGFRs (IC50 = 160.6 nM for HaCaT keratinocytes). Nazartinib decreases phosphorylation of EGFR in H3255, HCC827, and H1975 cells (EC50s = 5, 1, and 3 nM, respectively) and inhibits cell proliferation (EC50s = 9, 11, and 25 nM, respectively) but does not affect cell proliferation in cell lines containing wild-type EGFR. It reduces tumor growth in an HCC827 lung adenocarcinoma mouse xenograft model when administered at doses ranging from 3 to 100 mg/kg per day for 21 days.More related product prices
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₹5000-14200 - AG 1478 HYDROCHLORIDE
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₹1791-43040.2
Suppliers and manufacturers
A.J Chemicals
ATK CHEMICAL COMPANY LIMITED
BOC Sciences
Neostar United (Changzhou) Industrial Co., Ltd.
Zhejiang J&C Biological Technology Co.,Limited
InvivoChem
TargetMol Chemicals Inc.
ShenZhen Trendseen Biological Technology Co.,Ltd.
Wuhan Topule Biopharmaceutical Co., Ltd