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EGF816

EGF816 Structure
CAS No.
1508250-71-2
Chemical Name:
EGF816
Synonyms
EGF816;CS-1646;NVS-816;Nazartinib;EGF-816;EGF 816;EGF816|||NVS-816;EGF816 Nazartinib;Nazartinib (EGF816);Nazartinib (EGF816, NVS-816);EGF816, 98%, a novel EGFR inhibitor
CBNumber:
CB33040785
Molecular Formula:
C26H31ClN6O2
Molecular Weight:
495.02
MOL File:
1508250-71-2.mol
Modify Date:
2024/7/2 8:55:06
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EGF816 Properties

Density 1.28±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Soluble in DMSO
form Powder
pka 11.38±0.43(Predicted)
color Off-white to yellow

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
NFPA 704
0
2 0

EGF816 Chemical Properties,Uses,Production

Description

Nazartinib is an irreversible inhibitor of mutant EGF receptors (EGFRs). It is selective for EGFR mutant cell lines, including H3255 and HCC827 lung adenocarcinoma cells (IC50s = 6.11 and 1.52 nM, respectively) and resistant H1975 non-small cell lung cancer cells (NSCLC; IC50 = 4.18 nM), over cells expressing wild-type EGFRs (IC50 = 160.6 nM for HaCaT keratinocytes). Nazartinib decreases phosphorylation of EGFR in H3255, HCC827, and H1975 cells (EC50s = 5, 1, and 3 nM, respectively) and inhibits cell proliferation (EC50s = 9, 11, and 25 nM, respectively) but does not affect cell proliferation in cell lines containing wild-type EGFR. It reduces tumor growth in an HCC827 lung adenocarcinoma mouse xenograft model when administered at doses ranging from 3 to 100 mg/kg per day for 21 days.

EGF816 Preparation Products And Raw materials

Raw materials

Preparation Products

EGF816 Suppliers

Global( 105)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32836 60 Inquiry
BOC Sciences +1-631-485-4226 United States 19553 58 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29824 58 Inquiry
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 +1-2135480471 China 10522 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 United States 19973 58 Inquiry
ShenZhen Trendseen Biological Technology Co.,Ltd. 13417589054 China 11681 58 Inquiry
Wuhan Topule Biopharmaceutical Co., Ltd +8618327326525 China 8474 58 Inquiry
Zibo Hangyu Biotechnology Development Co., Ltd +86-0533-2185556 +8617865335152 China 10991 58 Inquiry
Supplier Advantage
A.J Chemicals 58
ATK CHEMICAL COMPANY LIMITED 60
BOC Sciences 58
career henan chemical co 58
Zhejiang J&C Biological Technology Co.,Limited 58
InvivoChem 58
TargetMol Chemicals Inc. 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 58
Wuhan Topule Biopharmaceutical Co., Ltd 58
Zibo Hangyu Biotechnology Development Co., Ltd 58

1508250-71-2(EGF816)Related Search:

EGF816 (S-enantiomer) Olmutinib XL-647 Genistein AZD 3759
AG 1478 HYDROCHLORIDE OSI-420 Anlotinib Tucatinib Neratinib
Poziotinib (HM781-36B) CO-1686 Dacomitinib (PF299804) AZD-9291
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Nazartinib (EGF816) EGF816 Nazartinib NVS-816 EGF816, 98%, a novel EGFR inhibitor Nazartinib (EGF816, NVS-816) (R,E)-N-(7-chloro-1-(1-(4-(dimethylamino)but-2-enoyl)azepan-3-yl)-1H-benzo[d]imidazol-2-yl)-2-methylisonicotinamide EGF816 Nazartinib CS-1646 EGF-816;EGF 816 N-[7-Chloro-1-[(3R)-1-[(2E)-4-(dimethylamino)-1-oxo-2-buten-1-yl]hexahydro-1H-azepin-3-yl]-1H-benzimidazol-2-yl]-2-methyl-4-pyridinecarboxamide 4-Pyridinecarboxamide, N-[7-chloro-1-[(3R)-1-[(2E)-4-(dimethylamino)-1-oxo-2-buten-1-yl]hexahydro-1H-azepin-3-yl]-1H-benzimidazol-2-yl]-2-methyl- EGF816|||NVS-816 1508250-71-2