ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >protein tyrosine kinase >CO-1686

CO-1686

CAS No.: 1374640-70-6

Chemical Name:: CO-1686

Synonyms: CS-851;CNX-419;AVL-301;CO-1686;ROCILETINIB;Pyridostadin;CO-1686, >=98%;Clovis CO-1686;CO-1686/CO1686;CO-1686 (AVL-301)

CBNumber:: CB22666396

Molecular Formula:: C27H28F3N7O3

Molecular Weight:: 555.55

MOL File:: 1374640-70-6.mol

MSDS File:: SDS

Modify Date:: 2023/6/8 9:03:09

Request For Quotation

CO-1686 Properties

Melting point	202 - 205°C (dec.)
Density	1.372±0.06 g/cm3(Predicted)
storage temp.	Amber Vial, -20°C Freezer, Under inert atmosphere
solubility	DMSO (Slightly), Methanol (Slightly)
form	Solid
pka	13.23±0.70(Predicted)
color	Off-White
CAS DataBase Reference	1374640-70-6

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P264-P270-P271-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P332+P313-P362+P364-P337+P313-P403+P233-P405-P501

Risk Statements

23-25-36

Safety Statements

HS Code

29335990

NFPA 704

	0
2		0

CO-1686 Chemical Properties,Uses,Production

Description

CO-1686 is an irreversible kinase inhibitor that specifically targets mutant forms of the epidermal growth factor receptor (EGFR) including T790M (K_i = 21.5 nM) with significantly reduced activity at the wild-type form of the receptor (K_i = 303.3 nM). CO-1686 has been shown to inhibit the proliferation of non-small cell lung cancer (NSCLC) cells expressing mutant EGFR with GI₅₀ values ranging from 7-32 nM in vitro, inducing apoptosis. It also demonstrates anti-tumor activity in NSCLC EGFR mutant xenograft and transgenic models dosed orally at 100 mg/kg/day.

Uses

CO 1686 is seen as an irreversible epidermal growth factor receptor (EFGR1) kinase inhibitor.

CO-1686 Preparation Products And Raw materials

Raw materials

N-[2-chloro-5-(trifluoroMethyl)-4-pyriMidinyl]-1,3-benzenediaMine N-BOC-M-PHENYLENEDIAMINE 2,4-Dichloro-5-trifluoromethylpyrimidine CO-1686 intermediate 1 tert-butyl (3-((2-chloro-5-(trifluoroMethyl)pyriMidin-4-yl)aMino)phenyl)carbaMate

N-(4-aminophenyl)acrylamide 1-(4-(3-Methoxy-4-nitrophenyl)piperazin-1-yl)ethanone 1-(4-(4-aMino-3-Methoxyphenyl)piperazin-1-yl)ethanone 5-Fluoro-2-nitroanisole 3-Chloropropionyl chloride

Acryloyl chloride

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Preparation Products

CO-1686 Suppliers

Global( 200)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	China	29798	60	Inquiry
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	China	32760	60	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29901	58	Inquiry
BOC Sciences	+1-631-485-4226	United States	19553	58	Inquiry
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	China	39916	58	Inquiry
Shanghai Yingrui Biopharma Co.,Ltd	21-33585366	CHINA	1320	58	Inquiry
Fuxin Pharmaceutical	+86-021-021-50872116 +8613122107989	China	10297	58	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	United States	19892	58	Inquiry

Supplier	Advantage
A.J Chemicals	58
CLEARSYNTH LABS LTD.	58
Capot Chemical Co.,Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
BOC Sciences	58
Chongqing Chemdad Co., Ltd	58
Shanghai Yingrui Biopharma Co.,Ltd	58
Fuxin Pharmaceutical	58
TargetMol Chemicals Inc.	58

CO-1686 Spectrum

CO-1686(1374640-70-6)¹HNMR

1374640-70-6(CO-1686)Related Search:

Volitinib Olmutinib XL-647 Genistein AZD 3759

AG 1478 HYDROCHLORIDE OSI-420 Anlotinib EGF816 Tucatinib

Neratinib Poziotinib (HM781-36B) Dacomitinib Ibrutinib Afatinib

AZD-9291 AVL-292 PLX4032

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CO-1686 AVL-301 CNX-419 CO-1686 (AVL-301) CO-1686/CO1686 N-[3-[[2-[[4-(4-Acetyl-1-piperazinyl)-2-methoxyphenyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]phenyl]-2-propenamide Clovis CO-1686 CO-1686(free base) Rociletinib(AVL-301,CNX-419,CO-1686) N-(3-(2-(4-(4-acetylpiperazin-1-yl)-2-methoxyphenylamino)-5-(trifluoromethyl)pyrimidin-4-ylamino)phenyl)acrylamide CO-1686, >=98% N-[3-[[2-[4-(4-acetylpiperazin-1-yl)-2-methoxyanilino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]phenyl]prop-2-enamide ROCILETINIB Rociletinib(CO1686) 2-Propenamide, N-[3-[[2-[[4-(4-acetyl-1-piperazinyl)-2-methoxyphenyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]phenyl]- Rociletinib (CO-1686, AVL-301) Co 1686 N-[3-[[2-[[4-(4-Acetyl-1-piperazinyl)-2-methoxyphenyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]phenyl]-2-propenamide N-[3-[[2-[[4-(4-Acetyl-1-piperazinyl)-2-methoxyphenyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]phenyl]-2-propenamide Co 1686 CO-1686(ROCILETINIB) Pyridostadin N-(3-((2-((4-(4-Acetylpiperazin-1-yl)-2-methoxyphenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl CO1686; CO-1686; CO 1686; AVL301; AVL 301; AVL-301; CNX419; CNX 419; CNX-419; ROCILETINIB. Rociletinib (CO1686,CNX419) CS-851 ROCILETINIB; AVL-301; CNX-419;CO 1686;CO1686 N-(3-((2-((4-(4-Acetylpiperazin-1-yl)-2-methoxyphenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)phenyl)prop-2-enamide CO-1686 (Rociletinib, AVL-301) Pyridostadin 3TFA CO-1686 USP/EP/BP Rociletinib (CO-1686, AVL-301, CNX-419) Rociletinib(free base) Pazufloxacin Monomer 1374640-70-6 C27H28F3N7O3 Inhibitors API