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OSI-420

OSI-420 Structure
CAS No.
183321-86-0
Chemical Name:
OSI-420
Synonyms
OSI-420;CP 373420;Erlotinib-10;OSI-420 impurity;β-Amyloid (1-42);ROSCOVITINE(CVC202);OSI-420 (free base);Erlotinib iMpurity H;Erlotinib impurity J;Erlotinib impurity N
CBNumber:
CB4501590
Molecular Formula:
C21H21N3O4
Molecular Weight:
379.41
MOL File:
183321-86-0.mol
MSDS File:
SDS
Modify Date:
2024/11/19 23:02:33
Request For Quotation

OSI-420 Properties

Melting point 140-142°C
Density 1.30
storage temp. -20°C Freezer
solubility insoluble in H2O; insoluble in EtOH; ≥51 mg/mL in DMSO
form A crystalline solid
color White to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312-P330-P501
NFPA 704
0
2 0

OSI-420 Chemical Properties,Uses,Production

Description

Desmethyl erlotinib is a metabolite of erlotinib . Erlotinib is a tyrosine kinase inhibitor which acts on the epidermal growth factor receptor (EGFR), inhibiting EGFR-associated kinase activity (IC50 = 2.5 μM). This inhibits tumor growth in human head and neck carcinoma HN5 tumor xenografts in mice with an ED50 value of 9 mg/kg. Erlotinib also suppresses cyclin-dependent kinase 2 (Cdk2) activity in breast cancer cells (IC50 = 4.6 μM) and JAK2 mutant JAK2V617F positive hematopoietic progenitor cells (IC50 = 5 μM), which is associated with polycythemia vera, idiopathic myelofibrosis, and essential thrombocythemia. Formulations containing erlotinib have been used to treat certain forms of cancer, including non-small cell lung cancer.

Chemical Properties

Off-White Solid

Uses

OSI-420 (Desmethyl Erlotinib,CP-473420) is an active metabolite of erlotinib which is an orally active EGFR tyrosin kinase inhibitor with IC50 of 2 and 20 nM for the inhibition of human EGFR and EGFR autophosphorylation in tumor cells.

OSI-420 Preparation Products And Raw materials

Raw materials

Preparation Products

OSI-420 Suppliers

Global( 122)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6257 58 Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6739 58 Inquiry
SynZeal Research Pvt Ltd +1 226-802-2078 Gujarat, India 6514 58 Inquiry
Pharma Affiliates 172-5066494 Haryana, India 6754 58 Inquiry
BOC Sciences +1-631-485-4226 United States 19552 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 32159 58 Inquiry
Career Henan Chemica Co +86-0371-86658258 +8613203830695 China 30231 58 Inquiry
Labnetwork lnc. +86-27-50766799 +8618062016861 China 19987 58 Inquiry
TargetMol Chemicals Inc. United States 38630 58 Inquiry
Moxin Chemicals +8617320513646 China 9684 58 Inquiry
Supplier Advantage
CLEARSYNTH LABS LTD. 58
Pharmaffiliates Analytics and Synthetics P. Ltd 58
SynZeal Research Pvt Ltd 58
Pharma Affiliates 58
BOC Sciences 58
TargetMol Chemicals Inc. 58
Career Henan Chemica Co 58
Labnetwork lnc. 58
TargetMol Chemicals Inc. 58
Moxin Chemicals 58

OSI-420 Spectrum

OSI-420(183321-86-0)1HNMR

183321-86-0(OSI-420)Related Search:

OSI-420-d4, Free Base (Desmethyl Erlotinib-d4) Erlotinib IMpurity C Erlotinib Erlotinib Impurity 35 2-Amino-4,5-bis(2-methoxyethoxy)benzonitrile
Erlotinib Impurity 67 Olmutinib XL-647 Genistein AZD 3759
AG 1478 HYDROCHLORIDE Anlotinib EGF816 Tucatinib Neratinib
Poziotinib (HM781-36B) CO-1686 Dacomitinib (PF299804)
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CP 373420 OSI-420 (free base) Erlotinib O-DesMethyl Metabolite Erlotinib iMpurity H Desmethyl Erlotinib (CP-473420, OSI-420) 6-O-Desmethyl Erlotinib 1 2-((4-((3-ethynylphenyl)amino)-7-(2-methoxyethoxy)quinazolin-6-yl)oxy)ethan-1-ol 2-((4-((3-Ethynylphenyl)amino)-7-(2-methoxyethoxy)quinazolin-6-yl)oxy)ethanol OSI-420 ROSCOVITINE(CVC202) Erlotinib-10 Erlotinib 6-O-Desmethyl Metabolite Erlotinib Hydrochloride iMpurity 9 2-((4-((3-ethynylphenyl)amino)-7-(2-methoxyethoxy) OSI-420 impurity Erlotinib O-Desmethyl Metabolite Isomer 2-((4-((3-ethynylphenyl)amino)-7-(2-methoxyethoxy)quizolin-6-yl)oxy)ethan-1-ol 6-O-Desmethyl Erlotinib Erlotinib impurity J Erlotinib impurity N Erlotinib O-Desmethyl Metabolite Isomer (M14) Erlotinib impurity 16/Desmethyl Erlotinib/2-((4-((3-ethynylphenyl)amino)-7-(2-methoxyethoxy)quinazolin-6-yl)oxy)ethan-1-ol Desmethyl Erlotinib (CP-473420, OSI-774) Ethanol, 2-[[4-[(3-ethynylphenyl)amino]-7-(2-methoxyethoxy)-6-quinazolinyl]oxy]- Erlotinib impurities405 Azilsartan medoxomil impurity247 Erlotinib O-Desmethyl Metabolite (M14) β-Amyloid (1-42) Erlotinib Impurity 167 Desmethyl Erlotinib, 10 mM in DMSO 183321-86-0 Inhibitors Intermediates & Fine Chemicals Metabolites & Impurities Pharmaceuticals Heterocycles