OSI-420
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OSI-420 속성
- 녹는점
- 140-142°C
- 밀도
- 1.30
- 저장 조건
- -20°C Freezer
- 용해도
- insoluble in H2O; insoluble in EtOH; ≥51 mg/mL in DMSO
- 물리적 상태
- 결정성 고체
- 색상
- White to off-white
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
OSI-420 C화학적 특성, 용도, 생산
개요
Desmethyl erlotinib is a metabolite of erlotinib . Erlotinib is a tyrosine kinase inhibitor which acts on the epidermal growth factor receptor (EGFR), inhibiting EGFR-associated kinase activity (IC50 = 2.5 μM). This inhibits tumor growth in human head and neck carcinoma HN5 tumor xenografts in mice with an ED50 value of 9 mg/kg. Erlotinib also suppresses cyclin-dependent kinase 2 (Cdk2) activity in breast cancer cells (IC50 = 4.6 μM) and JAK2 mutant JAK2V617F positive hematopoietic progenitor cells (IC50 = 5 μM), which is associated with polycythemia vera, idiopathic myelofibrosis, and essential thrombocythemia. Formulations containing erlotinib have been used to treat certain forms of cancer, including non-small cell lung cancer.화학적 성질
Off-White Solid용도
OSI-420 (Desmethyl Erlotinib,CP-473420) is an active metabolite of erlotinib which is an orally active EGFR tyrosin kinase inhibitor with IC50 of 2 and 20 nM for the inhibition of human EGFR and EGFR autophosphorylation in tumor cells.OSI-420 준비 용품 및 원자재
원자재
준비 용품
OSI-420 공급 업체
글로벌( 113)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Biochempartner | 0086-13720134139 |
candy@biochempartner.com | CHINA | 967 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |
BOC Sciences | +1-631-485-4226 |
inquiry@bocsci.com | United States | 19553 | 58 |
Career Henan Chemica Co | +86-0371-86658258 +8613203830695 |
laboratory@coreychem.com | China | 30250 | 58 |
HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 |
sales@hzclap.com | CHINA | 6313 | 58 |
Hangzhou Huarong Pharm Co., Ltd. | 571-86758373 +8613588754946 |
sales@huarongpharm.com | CHINA | 3149 | 58 |
Labnetwork lnc. | +86-27-50766799 +8618062016861 |
contact@labnetwork.com | China | 19994 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 |
support@targetmol.com | United States | 19973 | 58 |
Amadis Chemical Company Limited | 571-89925085 |
sales@amadischem.com | China | 131980 | 58 |
Shanghai Payne Pharmaceutical Technology Co.Ltd | 021-58123769 18678586262 |
info@paynepharm.com | China | 1354 | 58 |
OSI-420 관련 검색:
제니스테인
OSI-420-d4, Free Base (Desmethyl Erlotinib-d4)
Erlotinib IMpurity C
Erlotinib
Erlotinib Impurity 35
2-Amino-4,5-bis(2-methoxyethoxy)benzonitrile
Erlotinib Impurity 67
Olmutinib
XL-647
AZD 3759
AG 1478 HYDROCHLORIDE
Anlotinib
EGF816
Tucatinib
Neratinib
Poziotinib (HM781-36B)
CO-1686
Dacomitinib (PF299804)