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XL-647

XL-647 Structure
  • ₹0
  • Product name: XL-647
  • CAS: 781613-23-8
  • MF: C24H25Cl2FN4O2
  • MW: 491.3853032
  • EINECS:
  • MDL Number:MFCD23726660
  • Synonyms:Tesevatinib;Tesevatinib(XL647);XL-647;N-(3,4-dichloro-2-fluorophenyl)-6-Methoxy-7-(((3aR,6aS)-2-Methyloctahydrocyclopenta[c]pyrrol-5-yl)Methoxy)quinazolin-4-aMine;N-(3,4-Dichloro-2-fluorophenyl)-6-methoxy-7-[[(3aalpha,5beta,6aalpha)-octahydro-2-methylcyclopenta[c]pyrrol-5-yl]methoxy]-4-quinazolinamine;EXEL-7647;XL-647;XL 647;KD-019;Rel-N-(3,4-dichloro-2-fluorophenyl)-6-methoxy-7-2-methyloctahydrocyclopenta[c]pyrrol-5-yl)methoxy)quinazolin-4-amine
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Boiling point :567.9±50.0 °C(Predicted)
Density :1.356
storage temp. :Store at -20°C
solubility :DMF: 10 mg/ml; DMSO: 10 mg/ml; Ethanol: 10 mg/ml
form :A solid
pka :10.16±0.40(Predicted)
color :White to off-white

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H314 Causes severe skin burns and eye damage Skin corrosion/irritation Category 1A, B, C Danger GHS hazard pictograms P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501
Precautionary statements:
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

Description

XL 647 is a potent and selective EGFR phosphorylation inhibitor and may be used in the treatment of patients suffering from lung cancer. Orally available, multi-target tyrosine kinase inhibitor.

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